Faculty

Institution

Unit

Venue

Frank B. Gertler

Professor of Biology Emeritus

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Frank B. Gertler is currently serving as a Biology Professor of Biology Emeritus at Massachusetts Institute of Technology.

Honors

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Experiences

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Education

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Frank B. Gertler

Massachusetts Institute of Technology

Professor of Biology Emeritus

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cell biology molecular biology cancer biology oncology genetics tumor biology neuroscience cancer research cell signaling structural biology breast cancer medicinal research protein science signal transduction gene expression molecular cell biology cellular biology cell regulation mammalian biology cancer cells molecular regulation cell migration insect molecular biology cellular physiology cancer imaging cancer care breast oncology cancer genomics oncogenes vascular biology cell motility cellular neurobiology molecular cancer protein function cancer genetics cellular therapy tumor targeting receptor tyrosine kinases developmental cell experimental medicine enzyme inhibition cell biomechanics gene function cancer growth anti-cancer agents actin cytoskeleton protein transport embryonic development molecular neurobiology angiogenesis cell-matrix interactions signaling pathways gene regulation developmental genetics protein expression cell physiology cardiovascular physiology cell adhesion cell interactions amphiphilic system therapeutic efficacy growth cone motility endothelial barrier function actin-based motility filopodia formation vasodilator-stimulated phosphoprotein cancer cell invasion cell-to-cell spread axon guidance cytoskeletal dynamics tumor cell intravasation three-dimensional microfluidic model actin filament cdk inhibitor multisite phosphorylation hydroxyproline recognition growth cones developmental biology cytoskeleton cellular motility

Notable Scholarly Works

Notable Federal Grants

Collaborators

Figure S1 From Mena Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer. (2023)

Madeleine J. OudinLucie BarbierClaudia SchäferTatsiana KosciukMiles A. MillerSangyoon HanOliver JonasDouglas A. LauffenburgerFrank B. Gertler

triple-negative breast cancergene expressionpharmacologycancer geneticscancer researchgeneticscellular therapyanti-cancer agentsmena confers resistancebreast cancermolecular biologyoncologymedicinal researchoncogenescancer treatmentcancer biologydrug targetingtumor biology

Supplementary Figure Legends From Mena Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer. (2023)

Madeleine J. OudinLucie BarbierClaudia SchäferTatsiana KosciukMiles A. MillerSangyoon HanOliver JonasDouglas A. LauffenburgerFrank B. Gertler

immunologytriple-negative breast cancerpharmacologyradiation oncologycancer researchgynecologic oncologytherapeutic targetsdrug resistanceanti-cancer agentsmena confers resistancebreast canceroncologydrug targetingmedicinal researchcancer treatmentcancer biologybreast oncology

Supplementary Figure S2 From Reduced Proteolytic Shedding of Receptor Tyrosine Kinases is a Post-Translational Mechanism of Kinase Inhibitor Resistance. (2023)

Miles A. MillerMadeleine J. OudinRyan J. SullivanStephanie J. WangAaron S. MeyerHyungsoon ImDennie T. FrederickJenny TadrosLinda G. GriffithHakho LeeRalph WeisslederKeith T. FlahertyFrank B. GertlerDouglas A. Lauffenburger

pharmacologykinase inhibitor resistancecell signalingreceptor tyrosine kinasesmammalian biologymolecular biologyproteolytic sheddingpost-translational mechanismneuroscience

Supplementary Video S1 From Tumor Cell–Driven Extracellular Matrix Remodeling Drives Haptotaxis During Metastatic Progression. (2023)

Madeleine J. OudinOliver JonasTatsiana KosciukLiliane C. BroyeBruna C. GuidoJeff WyckoffDaisy RiquelmeJohn M. LamarSreeja B. AsokanCharlie WhittakerDuanduan MaRobert LangerMichael J. CimaKari B. WisinskiRichard O. HynesDouglas A. LauffenburgerPatricia J. KeelyJames E. BearFrank B. Gertler

immunologymetastasisradiation oncologycancer researchcancer imagingoncologycancer cellsmetastatic progressioncancer biologytumor biologyextracellular matrixcell biology

Abstract Lb243: Implantable and Insertable Miniature Dual-Axis Confocal (Dac) Microscope to Detect Epithelial-Mesenchymal Transition (Emt) in the Breast Cancer Microenvironment. Cancer Research (2021)

Ehsanul Hoque ApuSeock-Jin ChungMichael J. MandellaFrank SchonigFrank B. GertlerZhen QiuChristopher H. Contag

confocal microscopyinsertable miniatureepithelial-mesenchymal transitionvascular biologybreast cancertissue imagingcancer biologycell detectionhealth sciencesoncologic imagingdermatologycancer researchmicroscopy methodsbiomedical imagingbreast cancer microenvironmentphotomedicinecancer imagingmolecular biologyoncologymicroscopymedicinal research

Drosophila Enabled Promotes Synapse Morphogenesis and Regulates Active Zone Form and Function. Neural Development (2020)

Elizabeth M. McNeillCheryl ThompsonBrett BerkeVivian T. ChouJannette RuschApril DuckworthJamin DeProtoAlicia TaylorJulie GatesFrank GertlerHaig KeshishianDavid Van Vactor

active zone formdevelopmental neurobiologyneurosciencedevelopmental biology

Mechanosensing During Directed Cell Migration Requires Dynamic Actin Polymerization at Focal Adhesions. The Journal of Cell Biology (2019)

Julieann I. PuleoSara S. ParkerMackenzie R. RomanAdam W. WatsonKiarash Rahmani EliatoLeilei PengKathylynn SabodaDenise J. RoeRobert RosFrank B. GertlerGhassan Mouneimne

biophysicscell migrationcellular physiologymechanical engineeringcellular biologycell motilitymolecular and cellular biologytissue engineeringcell biomechanicsmolecular cell biologymechanotransductionfocal adhesionsdynamic actin polymerizationstructural biologybiomechanicsmembrane biologycell biology

Abstract 4031: Novel Tumor Intrinsic vs. Extrinsic Mechanisms of Resistance to Chemotherapy in Metastatic Disease. Cancer Research (2018)

Madeleine J. OudinLucie BarbierTatiana KosciukEmanuel KreidlFrank Gertler

pharmacologycancer managementcancer researchtherapy resistanceoncologycancer treatmentcancer biologytumor biologyextrinsic mechanismsmetastatic disease

The Rb Tumor Suppressor Regulates Epithelial Cell Migration and Polarity. Molecular Carcinogenesis (2018)

Tiziana ParisiMichele BalsamoFrank GertlerJacqueline A. Lees

carcinogenesiscell migrationcancer researchtumor suppressorsoncologycell polaritycancer biologytumor biologyepithelial cell migrationcell biology

Abstract 863: Neuronal Splicing Regulatory Factors Are Upregulated in Models of Epithelial-Mesenchymal Transition. Cancer Research (2017)

Yevgenia L. KhodorJulia FroeseFrank GertlerRobert A. WeinbergChristopher B. Burge

cell signalingneuro-oncologyneurologycancer carecancer managementepithelial-mesenchymal transitionvascular biologycancer biologyhealth sciencesregulatory factorscancer researchcancer treatmentcell regulationcellular neurobiologytumor biologybrain tumor researchoncologymedicinal researchneuroscience

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Frank B. Gertler

Professor of Biology Emeritus

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Frank B. Gertler is currently serving as a Biology Professor of Biology Emeritus at Massachusetts Institute of Technology.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Frank B. Gertler

Massachusetts Institute of Technology

Professor of Biology Emeritus

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Figure S1 From Mena Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer. (2023)

Madeleine J. OudinLucie BarbierClaudia SchäferTatsiana KosciukMiles A. MillerSangyoon HanOliver JonasDouglas A. LauffenburgerFrank B. Gertler

Supplementary Figure Legends From Mena Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer. (2023)

Madeleine J. OudinLucie BarbierClaudia SchäferTatsiana KosciukMiles A. MillerSangyoon HanOliver JonasDouglas A. LauffenburgerFrank B. Gertler

Supplementary Figure S2 From Reduced Proteolytic Shedding of Receptor Tyrosine Kinases is a Post-Translational Mechanism of Kinase Inhibitor Resistance. (2023)

pharmacologykinase inhibitor resistancecell signalingreceptor tyrosine kinasesmammalian biologymolecular biologyproteolytic sheddingpost-translational mechanismneuroscience

Supplementary Video S1 From Tumor Cell–Driven Extracellular Matrix Remodeling Drives Haptotaxis During Metastatic Progression. (2023)

immunologymetastasisradiation oncologycancer researchcancer imagingoncologycancer cellsmetastatic progressioncancer biologytumor biologyextracellular matrixcell biology

Ehsanul Hoque ApuSeock-Jin ChungMichael J. MandellaFrank SchonigFrank B. GertlerZhen QiuChristopher H. Contag

Drosophila Enabled Promotes Synapse Morphogenesis and Regulates Active Zone Form and Function. Neural Development (2020)

Elizabeth M. McNeillCheryl ThompsonBrett BerkeVivian T. ChouJannette RuschApril DuckworthJamin DeProtoAlicia TaylorJulie GatesFrank GertlerHaig KeshishianDavid Van Vactor

active zone formdevelopmental neurobiologyneurosciencedevelopmental biology

Mechanosensing During Directed Cell Migration Requires Dynamic Actin Polymerization at Focal Adhesions. The Journal of Cell Biology (2019)

Julieann I. PuleoSara S. ParkerMackenzie R. RomanAdam W. WatsonKiarash Rahmani EliatoLeilei PengKathylynn SabodaDenise J. RoeRobert RosFrank B. GertlerGhassan Mouneimne

Abstract 4031: Novel Tumor Intrinsic vs. Extrinsic Mechanisms of Resistance to Chemotherapy in Metastatic Disease. Cancer Research (2018)

Madeleine J. OudinLucie BarbierTatiana KosciukEmanuel KreidlFrank Gertler

pharmacologycancer managementcancer researchtherapy resistanceoncologycancer treatmentcancer biologytumor biologyextrinsic mechanismsmetastatic disease

The Rb Tumor Suppressor Regulates Epithelial Cell Migration and Polarity. Molecular Carcinogenesis (2018)

Tiziana ParisiMichele BalsamoFrank GertlerJacqueline A. Lees

carcinogenesiscell migrationcancer researchtumor suppressorsoncologycell polaritycancer biologytumor biologyepithelial cell migrationcell biology

Abstract 863: Neuronal Splicing Regulatory Factors Are Upregulated in Models of Epithelial-Mesenchymal Transition. Cancer Research (2017)

Yevgenia L. KhodorJulia FroeseFrank GertlerRobert A. WeinbergChristopher B. Burge

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