Faculty

Institution

Unit

Venue

Erik Nelson

Associate Professor of Molecular & Integrative Physiology

UIUC

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Molecular & Integrative Physiology

Erik Nelson is currently serving as a College Of Liberal Arts & Sciences Associate Professor of Molecular & Integrative Physiology at Uiuc.

Honors

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Experiences

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Education

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Erik Nelson

UIUC

Associate Professor of Molecular & Integrative Physiology

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cancer cells cell biology breast cancer cancer biology tumor biology immunology molecular cancer breast oncology metastasis oncogenes pharmacology endocrinology oncology endocrine-related cancers hormonal receptor physiology cancer immunosurveillance receptors cancer research clinical lipidology cancer discovery anti-cancer agents reproductive endocrinology cancer growth cholesterol homeostasis reproductive biology cell metabolism reproductive hormones endocrine mechanisms cancer treatment chemoprevention strategies endocrine research oxysterol immunoediting immune checkpoint inhibitors fish biology reproductive science comparative endocrinology breast cancer progression thyroid molecular cell biology lipoprotein metabolism cellular immune responses extracellular microvesicles estrogen receptor animal physiology molecular physiology tumor growth cancer letter thyroid hormone tumor targeting bone homeostasis breast cancer metastasis extracellular vesicles pharmacological research biomedical analysis cancer prevention immunologic mechanisms bone metabolism cholesterol metabolism lipid synthesis metabolic regulation drug targeting metabolic bone disease ovarian hormones breast cancer pathophysiology t-regulatory cell receptor (biochemistry) liver x receptors adipose tissue thyroid receptor subtypes estrogen receptor subtypes unfolded protein response goldfish liver 27-hydroxycholesterol links hypercholesterolemia hydroxycholesterol facilitates metabolic remodeling drug discovery metabolism signal transduction immune modulation

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1365: Histamine From Mast Cells Protects Against Breast Cancer Recurrence. Cancer Research (2025)

Claire P. SchaneAdam T. NelczykCheng ChenShruti V. BendreErin WeisserHashni E. GamageMohammed KadiriMichael T. McHenryJiyoung SeoYu WangNatalia KrawczynskaDhanya PradeepLara I. KockayaYifan FeiShin-Hsuan HsiaoNicki J. EngesethMichael K. WendtTimothy M. FanWilliam G. HelferichErik R. Nelson

metastasispathologytumor biologycancer biologycell biologymolecular cancermast cellcancer growthbreast cancer recurrencecancer cellsoncologybreast cancer

Abstract B063: The Cholesterol Efflux Protein, Abca1, Plays a Critical Role in Modulating Anti-Tumor Myeloid Immune Cell Functions. Cancer Immunology Research (2025)

Shruti V BendreNatalia KrawczynskaRajendra K CYu WangShaunak BhogaleErin WeisserBasel HajyousifSimon HanAvni SinghClaire P. SchaneAdam T. NelczykDhanya PradeepAnasuya Das GuptaLara KockayaHashni Epa Vidana GamageKevin Van BortleEmad TajkorshidSaurabh SinhaWendy A. WoodwardWonhwa ChoErik R Nelson

tumor biologycancer immunotherapyimmunologycell biologycholesterol effluximmunotherapymolecular cancercholesterol efflux proteincancer immunosurveillancetumor microenvironmentcancer cellscholesterol homeostasisimmune checkpoint inhibitorsoncologycancer biology

A Necrosis Inducer Promotes an Immunogenic Response and Destroys Ovarian Cancers in Mouse Xenografts and Patient Ascites Organoids. Cancer Letters (2025)

Darjan DurakiMusarrat JabeenChengjian MaoLawrence WangSantanu GhoshXinyi DaiJunyao ZhuMatthew W BoudreauErik R NelsonPaul J HergenrotherGeorgina ChengDavid J Shapiro

gynecologic oncologyinflammationcancer cellsapoptosistumor biologyendocrine-related cancerscell deathimmunologyovarian hormonesgynecologymouse xenograftspatient ascites organoidsnecrosis inducerovarian cancer

Cholesterol Efflux Protein, Abca1, Supports Anti-Cancer Functions of Myeloid Immune Cells. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Shruti V. BendreYu WangBasel HajyousifK C RajendraShounak G. BhogaleDhanya PradeepNatalia KrawczynskaClaire P. SchaneErin WeisserAvni SinghSimon HanHannah KimLara KockayaAnasuya Das GuptaAdam T. NelczykHashni Epa Vidana GamageYifan FeiXingyu GuoRyan J. DeatonMaria SverdlovPeter H. GannSaurabh SinhaKun WangKevin Van BortleEmad TajkorshidWendy A. WoodwardWonhwa ChoErik R. Nelson

metastasisradiation oncologytumor biologyimmunologycholesterol homeostasismolecular cancercholesterol efflux proteincancer growthcancer immunosurveillancecancer cellsabca1 activitytumor microenvironmentcancer biology

Cholesterol-Targeting Wnt–β-Catenin Signaling Inhibitors for Colorectal Cancer. Nature Chemical Biology (2025)

Ashutosh SharmaJulian ZalejskiShruti Vijay BendreSimona KavrokovaHale Siir HasdemirDefne Gorgun OzgulbasJiachen SunKoralege C PathmasiriRuicheng ShiAhmed AloulouKyli BerkleyCharles F DelisleYoung WangErin WeisserPawanthi BuwenekaDominick Pierre-JacquesSayandeb MukherjeeDiana A AbbasiDaesung LeeBo WangVladimir GevorgyanStephanie M ColognaEmad TajkhorshidErik R NelsonWonhwa Cho

colorectal cancermolecular cancercancer researchcancer discoverychemoprevention strategiespharmacologycancer cellsoncology

Co-Targeting of Metabolism Using Dietary and Pharmacologic Approaches Reduces Breast Cancer Metastatic Burden. npj Breast Cancer (2025)

Qianying ZuoJin Young YooErik R. NelsonMatthew J. SikoraRebecca B. RigginsZeynep Madak-Erdogan

breast oncologyoncogenesmetastasisendocrine-related cancerstumor biologyketogenic dietcell biologymetabolic pathwaysmolecular cancercell metabolismmetabolic remodelingpharmacologymetastatic breast cancercancer metastatic burdenbreast cancer

Role of Protein Regulators of Cholesterol Homeostasis in Immune Modulation and Cancer Pathophysiology. Endocrinology (2025)

Yu WangShruti V BendreSteven A KrauklisAndrew J SteelmanErik R Nelson

tumor biologyoncologyimmunologycell biologymolecular cancerimmune systemoxysterolcancer researchcancer cellscholesterol homeostasisimmune modulationtumor microenvironmentcancer biology

Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice. ACS Central Science (2025)

Michael P. MulliganMatthew W. BoudreauBrooke A. BouwensYoongyeong LeeHunter W. CarrellJunyao ZhuSpyro MoussesDavid J. ShapiroErik R. NelsonTimothy M. FanPaul J. Hergenrother

breast oncologyoncogenesradiation oncologyendocrine-related cancerstumor biologyanti-cancer agentssingle dosepharmacologytherapeutic targetscancer cellsestrogen receptor αcancer treatmentoncologybreast cancer

27-Hydroxycholesterol Enhances Secretion of Extracellular Vesicles by Ros-Induced Dysregulation of Lysosomes. Endocrinology (2024)

Anasuya Das GuptaJaena ParkJanet E SorrellsHannah KimNatalia KrawczynskaDhanya PradeepYu WangHashni Epa Vidana GamageAdam T NelczykStephen A BoppartMarni D BoppartErik R Nelson

lipidsmitochondrial dysfunctiontumor biologylipoprotein metabolismcell signalingimmunologycell biologylipid peroxidationcell metabolismev secretionautophagyoxidative stressextracellular microvesiclesfree radical biologylipid synthesisextracellular vesicles

7065 Eradication of Metastatic Er-Positive Breast, Ovarian, Endometrial and Lung Cancer in Mouse Xenografts and Patient Derived Organoids. Journal of the Endocrine Society (2024)

D J ShapiroD DurakiS GhoshJ ZhuC MaoJ KimM JabeenM W BoudreauM P MulliganR RomeroY HanJ ZhangE R NelsonO OlopadeG ChangP J Hergenrother

oncogenesmetastasisradiation oncologygynecologic oncologytumor biologycancer cellsendocrine-related cancerscancer biologypatient derived organoidscell biologymolecular cancerlung cancermouse xenograftstumor suppressorsovarian cancerbreast cancer

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Erik Nelson

Associate Professor of Molecular & Integrative Physiology

UIUC

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Molecular & Integrative Physiology

Erik Nelson is currently serving as a College Of Liberal Arts & Sciences Associate Professor of Molecular & Integrative Physiology at Uiuc.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Erik Nelson

UIUC

Associate Professor of Molecular & Integrative Physiology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1365: Histamine From Mast Cells Protects Against Breast Cancer Recurrence. Cancer Research (2025)

metastasispathologytumor biologycancer biologycell biologymolecular cancermast cellcancer growthbreast cancer recurrencecancer cellsoncologybreast cancer

Abstract B063: The Cholesterol Efflux Protein, Abca1, Plays a Critical Role in Modulating Anti-Tumor Myeloid Immune Cell Functions. Cancer Immunology Research (2025)

A Necrosis Inducer Promotes an Immunogenic Response and Destroys Ovarian Cancers in Mouse Xenografts and Patient Ascites Organoids. Cancer Letters (2025)

Darjan DurakiMusarrat JabeenChengjian MaoLawrence WangSantanu GhoshXinyi DaiJunyao ZhuMatthew W BoudreauErik R NelsonPaul J HergenrotherGeorgina ChengDavid J Shapiro

Cholesterol Efflux Protein, Abca1, Supports Anti-Cancer Functions of Myeloid Immune Cells. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Cholesterol-Targeting Wnt–β-Catenin Signaling Inhibitors for Colorectal Cancer. Nature Chemical Biology (2025)

colorectal cancermolecular cancercancer researchcancer discoverychemoprevention strategiespharmacologycancer cellsoncology

Co-Targeting of Metabolism Using Dietary and Pharmacologic Approaches Reduces Breast Cancer Metastatic Burden. npj Breast Cancer (2025)

Qianying ZuoJin Young YooErik R. NelsonMatthew J. SikoraRebecca B. RigginsZeynep Madak-Erdogan

Role of Protein Regulators of Cholesterol Homeostasis in Immune Modulation and Cancer Pathophysiology. Endocrinology (2025)

Yu WangShruti V BendreSteven A KrauklisAndrew J SteelmanErik R Nelson

tumor biologyoncologyimmunologycell biologymolecular cancerimmune systemoxysterolcancer researchcancer cellscholesterol homeostasisimmune modulationtumor microenvironmentcancer biology

Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice. ACS Central Science (2025)

Michael P. MulliganMatthew W. BoudreauBrooke A. BouwensYoongyeong LeeHunter W. CarrellJunyao ZhuSpyro MoussesDavid J. ShapiroErik R. NelsonTimothy M. FanPaul J. Hergenrother

27-Hydroxycholesterol Enhances Secretion of Extracellular Vesicles by Ros-Induced Dysregulation of Lysosomes. Endocrinology (2024)

Anasuya Das GuptaJaena ParkJanet E SorrellsHannah KimNatalia KrawczynskaDhanya PradeepYu WangHashni Epa Vidana GamageAdam T NelczykStephen A BoppartMarni D BoppartErik R Nelson

7065 Eradication of Metastatic Er-Positive Breast, Ovarian, Endometrial and Lung Cancer in Mouse Xenografts and Patient Derived Organoids. Journal of the Endocrine Society (2024)

D J ShapiroD DurakiS GhoshJ ZhuC MaoJ KimM JabeenM W BoudreauM P MulliganR RomeroY HanJ ZhangE R NelsonO OlopadeG ChangP J Hergenrother

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