Faculty

Institution

Unit

Venue

Eric Oldfield

Harriet A Harlin Professor of Chemistry Professor

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Chemistry

School of Chemical Sciences

Department of Chemistry

Eric Oldfield is currently serving as a College Of Liberal Arts & Sciences Harriet A Harlin Professor of Chemistry Professor at Uiuc.

Honors

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Experiences

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Education

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Eric Oldfield

UIUC

Harriet A Harlin Professor of Chemistry Professor

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biochemistry chemistry nuclear magnetic resonance enzyme inhibition magnetic resonance biophysics molecular structure protein structure biomolecular structure biophysical chemistry enzymes structural molecular biology biological chemistry structural chemistry chemical structure protein science drug discovery pharmacology transition metal chemistry nuclear magnetic resonance spectroscopy structure-function enzyme kinetics structural biology magnetic resonance spectroscopy altmetric attention score medicinal chemistry protein nmr enzyme catalysis spectra-structure correlation quantum chemistry antimicrobial agents medicinal research coordination chemistry parasitic protozoa chemical sciences membrane science protein chemistry antiparasitic agent pharmacological research pharmaceutical chemistry antimicrobial compounds lipid chemistry antimicrobial chemotherapy surface electrochemistry nuclear quadrupole resonance protein x-ray crystallography chemical shifts lipid movement mechanisms of action inorganic materials proteinlipid interaction inorganic compounds rational drug design biomolecular analysis donut icon african trypanosomiasis drug development antibacterial agents natural product biosynthesis membrane systems drug targets conformational studies escherichia coli theoretical inorganic chemistry social media presence lipid science mycobacterium tuberculosis toxoplasma gondii nmr chemical shifts solid-state nmr staphylococcus aureus cell wall biosynthesis chemical shift tensors chemical shift plasmodium falciparum electrochemical nmr inorganic solids future medicinal chemistry infectious diseases x-ray crystallography biomolecular engineering

Notable Scholarly Works

Notable Federal Grants

Collaborators

Activity of Antibacterial/Antifungal Compounds Against the Protozoan Parasite, Toxoplasma Gondii. ACS Infectious Diseases (2025)

Davinder SinghMelissa A. SledaSatish R. MalwalAkanksha M. PandeyYiyuan ChenRuijie ZhouFeyisola AdewoleKatie SadowskaOluseye K. OnajoleSilvia N. J. MorenoEric Oldfield

microbiologymitochondrial membrane potentialbioactive compoundsantimicrobial chemotherapyantiparasitic agentantimicrobial compoundsantibioticsantifungal agentspharmacologyprotozoan parasitenatural product researchantimicrobial agentsenzyme inhibitiontoxoplasma gondii tachyzoites

Activity of Carbazole, Aminoguanidine and Diamine Anti-Infectives Against Toxoplasma Gondii. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Davinder SinghMelissa A. SledaAkanksha PandeySatish R. MalwalYiyuan ChenRuijie ZhouFeyisola AdewoleKatie SadowskaOluseye K. OnajoleSilvia N.J. MorenoEric Oldfield

microbiologypharmaceutical chemistryantimicrobial compoundsantimicrobial chemotherapydrug resistancemedicinal chemistryantiparasitic agenttoxoplasma gondiiantibioticsantifungal agentspharmacologyproton motive forceantimicrobial agentsenzyme inhibitiondiamine sq109

Anti-Parasitics With a Triple Threat: Targeting Parasite Enzymes, the Proton Motive Force, and Host Cell-Mediated Killing. ACS Infectious Diseases (2025)

Akanksha M. PandeySatish R. MalwalMariana Valladares-DelgadoLiesangerli Labrador-FagúndezBruno G. StellaLuis José Díaz-PérezAndré Rey-CibatiDavinder SinghMarianna StampolakiSangjin HongRobert B. GennisAntonios KolocourisGustavo BenaimEric Oldfield

parasitic protozoahost cell macrophagesvisceral leishmaniasisph gradient collapseantiparasitic agentbiological chemistrybiochemistrypharmacologydrug targetstherapeutic targetsproton motive forceenzyme inhibitiondrug discoverycellular biochemistry

Broad-Spectrum Activity and Mechanisms of Action of Sq109 on a Variety of Fungi. ACS Infectious Diseases (2025)

Satish R. MalwalRocio Garcia-RubioMilena KordalewskaHoja PattersonChi ZhangJorge D. CalderinRuijie ZhouAkanksha M. PandeyErika ShorDavid S. PerlinNathan P. WiederholdLuis Ostrosky-ZeichnerRutilio FrattiCarol NacyEric Oldfield

tuberculosis drug sq109microbiologyfungusfungal geneticsmicrobial pathogenesisfungal pathogensbroad-spectrum activityfungal ecologymedical mycologyantifungal agentspharmacologyantimicrobial agentsfungal physiology

Lipophilic Bisphosphonates Reduced Cyst Burden and Ameliorated Hyperactivity of Mice Chronically Infected With Toxoplasma Gondii. mBio (2024)

Melissa A. SledaZaid F. PitafiWenZhan SongEric OldfieldSilvia N. J. Moreno

parasitologymicrobiologyparasitic protozoadrug metabolismmitochondrial functionmolecular metabolismlipophilic bisphosphonatestoxoplasma gondiibioorganic chemistrybiochemistrypharmacologycoenzyme qmitochondrial dynamicsenzyme inhibitioncellular biochemistry

The Tuberculosis Drug Candidate Sq109 and Its Analogs Have Multistage Activity Against Plasmodium Falciparum. ACS Infectious Diseases (2024)

Savannah J. WatsonMariëtte E. van der WattAnjo TheronJanette ReaderSizwe TshabalalaErica ErlankLizette L. KoekemoerMariska NaudeMarianna StampolakiFeyisola AdewoleKatie SadowskaPilar Pérez-LozanoAndreea L. TurcuSantiago VázquezJihee KoBen MazurekDavinder SinghSatish R. MalwalMathew NjorogeKelly ChibaleOluseye K. OnajoleAntonios KolocourisEric OldfieldLyn-Marié Birkholtz

tuberculosispharmacological researchinfectious diseasesantiparasitic agentmalariapulmonary tuberculosispharmacologytherapeutic targetstropical medicineasexual blood stagesenzyme inhibitiondrug discoverymultistage activitystructure-activity relationships

Distinct Energy-Coupling Factor Transporter Subunits Enable Flavin Acquisition and Extracytosolic Trafficking for Extracellular Electron Transfer in Listeria Monocytogenes. mBio (2023)

Rafael Rivera-LugoShuo HuangFrank LeeRaphaël MéheustAnthony T. IavaroneAshley M. SidebottomEric OldfieldDaniel A. PortnoySamuel H. Light

microbiologypathogenic bacteriaenzymesbiological macromoleculesecf exporter genesmolecular microbiologymicrobial pathogenesisbacteriastructural molecular biologyredox biologybiological chemistrybiochemistrybacteriologyvirulence factorsecf transporter complexesmolecular biologyenergy-coupling factorcellular biochemistry

Investigation Into the Mechanism of Action of the Tuberculosis Drug Candidate Sq109 and Its Metabolites and Analogues in Mycobacteria. Journal of Medicinal Chemistry (2023)

Satish R. MalwalBen MazurekJihee KoPujun XieChikako BarnesChristine VarvitsiotisMatthew D. ZimmermanSamir OlatunjiJaeyong LeeMin XieJansy SarathyMartin CaffreyNatalie C. J. StrynadkaVéronique DartoisThomas DickBom Nae Rin LeeDavid G. RussellEric Oldfield

sq109 analoguesmicrobiologytuberculosisenzymesmolecular metabolismcell wall biosynthesismycobacterium tuberculosisbiosynthesisbiological chemistrybiochemistrymedical microbiologyantibacterial agentsantimicrobial agentsenzyme inhibitionpulmonary tuberculosis

Phosphoantigens Glue Butyrophilin 3A1 and 2A1 to Activate Vγ9Vδ2 T Cells. Nature (2023)

Linjie YuanXianqiang MaYunyun YangYingying QuXin LiXiaoyu ZhuWeiwei MaJianxin DuanJing XueHaoyu YangJian-Wen HuangSimin YiMengting ZhangNingning CaiLin ZhangQingyang DingKecheng LaiChang LiuLilan ZhangXinyi LiuYirong YaoShuqi ZhouXian LiPanpan ShenQing ChangSatish R. MalwalYuan HeWenqi LiChunlai ChenChun-Chi ChenEric OldfieldRey-Ting GuoYonghui Zhang

vγ9vδ2 t cellsimmunologic mechanismscell biologycell signalingcancer cellsoncogenesprotein structurebiological chemistrymolecular cell biologystructural molecular biologyalpaca-multiple pags functionsignal transductionmolecular biologyprotein functioncomposite interface

Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate Sq109 Against Bacteria and Protozoa: Identification of Lead Compounds Against Mycobacterium Abscessus and Malaria Parasites. ACS Infectious Diseases (2023)

Marianna StampolakiSatish R. MalwalNadine Alvarez-CabreraZijun GaoMohammad MoniruzzamanSvitlana O. BabiiNikolaos NazirisAndré Rey-CibatiMariana Valladares-DelgadoAndreea L. TurcuKyung-Hwa BaekTrong-Nhat PhanHyeryon LeeMattheo AlcarazSavannah WatsonMariette van der WattDina CoertzenNatasa EfstathiouMaria ChountoulesiCarolyn M. ShoenIoannis P. PapanastasiouJose BreaMichael H. CynamonLyn-Marié BirkholtzLaurent KremerJoo Hwan NoSantiago VázquezGustavo BenaimCostas DemetzosHelen I. ZgurskayaThomas DickEric OldfieldAntonios D. Kolocouris

microbiologytuberculosisantimicrobial agentscell wall biosynthesisplasmodium falciparummycobacterium tuberculosisantimicrobial compoundsantimicrobial chemotherapyantiparasitic agentclinical microbiologyantibioticspulmonary tuberculosispharmacologyantibacterial agentsantimicrobial resistanceenzyme inhibitiondrug discovery

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Eric Oldfield

Harriet A Harlin Professor of Chemistry Professor

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Chemistry

School of Chemical Sciences

Department of Chemistry

Eric Oldfield is currently serving as a College Of Liberal Arts & Sciences Harriet A Harlin Professor of Chemistry Professor at Uiuc.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Eric Oldfield

UIUC

Harriet A Harlin Professor of Chemistry Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Activity of Antibacterial/Antifungal Compounds Against the Protozoan Parasite, Toxoplasma Gondii. ACS Infectious Diseases (2025)

Davinder SinghMelissa A. SledaSatish R. MalwalAkanksha M. PandeyYiyuan ChenRuijie ZhouFeyisola AdewoleKatie SadowskaOluseye K. OnajoleSilvia N. J. MorenoEric Oldfield

Activity of Carbazole, Aminoguanidine and Diamine Anti-Infectives Against Toxoplasma Gondii. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Davinder SinghMelissa A. SledaAkanksha PandeySatish R. MalwalYiyuan ChenRuijie ZhouFeyisola AdewoleKatie SadowskaOluseye K. OnajoleSilvia N.J. MorenoEric Oldfield

Anti-Parasitics With a Triple Threat: Targeting Parasite Enzymes, the Proton Motive Force, and Host Cell-Mediated Killing. ACS Infectious Diseases (2025)

Broad-Spectrum Activity and Mechanisms of Action of Sq109 on a Variety of Fungi. ACS Infectious Diseases (2025)

Lipophilic Bisphosphonates Reduced Cyst Burden and Ameliorated Hyperactivity of Mice Chronically Infected With Toxoplasma Gondii. mBio (2024)

Melissa A. SledaZaid F. PitafiWenZhan SongEric OldfieldSilvia N. J. Moreno

The Tuberculosis Drug Candidate Sq109 and Its Analogs Have Multistage Activity Against Plasmodium Falciparum. ACS Infectious Diseases (2024)

Distinct Energy-Coupling Factor Transporter Subunits Enable Flavin Acquisition and Extracytosolic Trafficking for Extracellular Electron Transfer in Listeria Monocytogenes. mBio (2023)

Rafael Rivera-LugoShuo HuangFrank LeeRaphaël MéheustAnthony T. IavaroneAshley M. SidebottomEric OldfieldDaniel A. PortnoySamuel H. Light

Investigation Into the Mechanism of Action of the Tuberculosis Drug Candidate Sq109 and Its Metabolites and Analogues in Mycobacteria. Journal of Medicinal Chemistry (2023)

Phosphoantigens Glue Butyrophilin 3A1 and 2A1 to Activate Vγ9Vδ2 T Cells. Nature (2023)

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10 / page