Edwin J. Ostrin, M.D., Ph.D.

Edwin J. Ostrin, M.D., Ph.D., is an Associate Professor at The University of Texas MD Anderson Cancer Center. His research focuses on lung cancer screening, thoracic oncology, and multi-cancer risk stratification, with recent work validating blood-based assays for personalized breast and lung cancer risk assessment. He investigates the impact of comorbidities on screening mortality benefits and evaluates risk prediction models, including the Brock and Sybil models, for persistent pulmonary nodules. His latest publications also explore associations between environmental exposures, such as per- and polyfluoroalkyl substances, and lung cancer mortality in large cohort studies. Additionally, his translational work examines metabolic vulnerabilities, including long-chain sulfatide enrichment, in pancreatic cancer progression. His research integrates cancer biology, pathology, and cell biology to advance early detection and risk stratification strategies.