E.J. Shpall

Elizabeth J. Shpall is a Professor of Medicine and the Deputy Chair of the Department of Stem Cell Transplantation and Cellular Therapy at The University of Texas MD Anderson Cancer Center. Her research focuses on cellular therapy, hematopoietic stem cell transplantation, and the immunobiology of hematological malignancies, with particular emphasis on optimizing transplant outcomes in leukemia and myelodysplastic syndromes. Her recent work includes pioneering engineered exosomes targeting KRASG12D in pancreatic cancer, defining CREM as a regulatory checkpoint in CAR and IL-15 NK cell signaling, and refining prognostic models using TP53-mutant variant allele frequency and measurable residual disease in acute lymphoblastic leukemia. She has authored over 400 publications and leads multiple national and international collaborative trials in adoptive cellular immunotherapy.