Dr. Darren Seals

Associate Professor

Appalachian State University

Affiliations

Appalachian State University

University College

College Of Arts And Sciences

Department Of Biology

Dr. Darren Seals is currently serving as an Appalachian State University Associate Professor at Appalachian State University.

Honors

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Experiences

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Education

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Dr. Darren Seals

Appalachian State University

Associate Professor

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cell biology molecular biology immunology biochemistry enzymes tumor biology cancer biology cancer research oncology fish biology protein science molecular cell biology cancer cells molecular cancer protein function adams family protein structure protein folding protein design protein engineering structural molecular biology enzyme inhibition transition metal chemistry medical virology general virology virus research cancer care cell research cancer letter oncogenes brain tumor research metalloproteins multi-protein assembly protein assembly protein chemistry cancer growth metabolic regulation molecular virology viral pathogenesis cancer treatment cancer genomics tumor targeting cancer genetics multiple functions multidomain proteins adaptor protein podosome formation protease-driven invasion src-transformed cells tumor growth m2 macrophages metastatic properties glioma cancer immunotherapy cell division cell signaling autophagy experimental medicine pharmacology therapeutic targets carcinogenesis molecular physiology developmental biology metastasis cellular therapy stem cell research sarcoma molecular and cellular biology systems biology matrix biology tumor microenvironment cancer discovery cytoskeleton morphogenesis radiation oncology ovarian cancer developmental cell cell and molecular biology jama oncology cell death medicinal research molecular medicine proteome research cellular differentiation stem cells extracellular matrix signal transduction cellular physiology pathology cellular biochemistry

Notable Scholarly Works

Notable Federal Grants

Collaborators

Oncolytic Vesicular Stomatitis Virus Modulates Invadopodia Morphology and Inhibits Invasive Behaviors in Src-Transformed Fibroblasts. Virology (2026)

The Presence and Potential Role of Aldh1A2 in the Glioblastoma Microenvironment. Cells (2021)

Oncolytic Vesicular Stomatitis Viruses Selectively Target M2 Macrophages. Virus Research (2020)

viral pathogenesisvirologymedical virologyinfectious diseasespathogenesisvirus researchimmunologymolecular virologygeneral virologym2 macrophages

Tks5 Sh3 Domains Exhibit Differential Effects on Invadopodia Development. PLoS ONE (2020)

The Anti-Angiogenic and Cytotoxic Effects of the Boswellic Acid Analog Ba145 Are Potentiated by Autophagy Inhibitors. Molecular Cancer (2015)

Tmic-07Aldh1A2 is a Candidate Biomarker for M2-Type Macrophages in Glioblastoma. Neuro-Oncology (2015)

cancer immunotherapypathologymolecular canceroncogenestumor microenvironmentcancer letterbiomarkersbrain tumor researchcancer discoverymetastasistumor biologyimmunologymedicinal researchcell biologycancer cellsgliomaneuroimmunology

Src‐Dependent Tks5 Phosphorylation Regulates Invadopodia‐Associated Invasion in Prostate Cancer Cells. The Prostate (2013)

Abstract 503: Investigating the Role of Tks5 and Invadopodia in Prostate Tumor Progression. Cancer Research (2012)

Metabolic Regulation of Invadopodia and Invasion by Acetyl-Coa Carboxylase 1 and De Novo Lipogenesis. PLoS ONE (2012)

Kristen E. N. ScottFrances B. WheelerAmanda L. DavisMichael J. ThomasJames M. NtambiDarren F. SealsSteven J. Kridel

metabolic regulationbiochemistrymolecular biologycell biologyenzymes

Abstract Lb-115: Epha2/Ephrina1 System May Regulate Invadopodia Formation of Glioblastoma Multiforme (Gbm) Cells. Cancer Research (2011)