Faculty

Institution

Unit

Venue

Douglas Alan Mitchell

Professor

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Chemistry

School of Chemical Sciences

Department of Chemistry

Douglas Alan Mitchell is currently serving as a College Of Liberal Arts & Sciences Professor at Uiuc.

Honors

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Experiences

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Education

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Douglas Alan Mitchell

UIUC

Professor

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biochemistry peptides molecular biology peptide synthesis peptide science biosynthesis biomolecular engineering enzymes biological chemistry chemical biology microbiology protein science biomolecules enzyme inhibition protein structure structural molecular biology natural product biosynthesis antimicrobial agents protein engineering protein biosynthesis peptide library biomolecular structure drug discovery molecular informatics peptide engineering natural product research protein synthesis modified peptides proteome research natural products medicinal chemistry biological macromolecules antimicrobial compounds natural product synthesis enzyme catalysis biotransformation structural bioinformatics molecular metabolism molecular microbiology lasso peptides biocatalysis protein bioinformatics ribosomal peptides applied microbiology structure-function enzyme kinetics microbial proteomics peptide therapeutics precursor peptides redox biology rational drug design nitrosative stress reactive nitrogen species antibacterial agents virulence factors biomolecular structure prediction precursor peptide antimicrobial chemotherapy bacteriology lasso peptide genome mining protein chemistry redox chemistry protein x-ray crystallography protein structure prediction modified peptide active site escherichia coli drug development drug targets bioorganometallic chemistry ripp antibiotics methyl-coenzyme m reductase cell wall biosynthesis lasso peptide biosynthesis nitric oxide synthase sls biosynthesis enzymatic modification structure-activity relationships bioorganic chemistry

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Versatile Enzymatic Pathway for Modification of Peptide C-Termini. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Shravan R. DommarajuSanath K. KandyHengqian RenDominic P. LucianoShogo FujikiDavid SarlahHuimin ZhaoJonathan R. ChekanDouglas A. Mitchell

bioconjugationpeptidespeptide engineeringpeptide synthesispeptide sciencedaptide biosynthesis remainbiomolecular engineeringenzymesbiomoleculesmodified peptidesdaptide biosynthesisbiochemistrybiosynthesis

Bps2025 - Lasso Cyclase Functions as a Chaperone That Mediates Peptide Folding and Binding. Biophysical Journal (2025)

Song YinSusanna E. BarrettDouglas A. MitchellDiwakar Shukla

lasso cyclase functionsbiological macromoleculesprotein assemblypeptidesprotein functionpeptide engineeringpeptide scienceprotein structuremolecular biologybiological chemistrystructural molecular biologybiochemistryprotein scienceprotein engineeringprotein folding

Cell-Free Synthetic Biology for Natural Product Biosynthesis and Discovery. Chemical Society Reviews (2025)

Andrew J. RiceTien T. SwordKameshwari ChenganDouglas A. MitchellNigel J. MounceySimon J. MooreConstance B. Bailey

synthetic circuitsbiological engineeringbiotechnologyactivity profilingbiomolecular engineeringnatural product biosynthesisbiomoleculescell-free synthetic biologypathway engineeringnatural product researchsynthetic biologybiosynthesis

Lantibiotic-Producing Bacteria Impact Microbiome Resilience and Colonization Resistance. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Cody G. ColeZhenrun J. ZhangShravan R. DommarajuQiwen DongRosemary L. PopeSophie S. SonEmma J. McSpaddenChe K. WoodsonHuaiying LinNicholas P. DyllaAshley M. SidebottomAnitha SundararajanDouglas A. MitchellEric G. Pamer

microbiomeantimicrobial agentsgut microbesantimicrobial resistanceantimicrobial resistance genesantibiotic resistancelantibiotic-producing bacteriaclinical microbiologycolonization resistancedysbiosisinfectious diseasesbacteriamicrobiome resiliencemicrobiology

Mibig 4.0: Advancing Biosynthetic Gene Cluster Curation Through Global Collaboration. Nucleic acids research (2025)

Douglas Alan Mitchell

genome biologybiomedical informaticsfunctional genomicshigh throughput sequencinggeneticsomics datasetsmolecular biologybiotechnology advancemibig 4.0bioinformatics

Peptidic Tryptophan Halogenation by a Promiscuous Flavin-Dependent Enzyme. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Andrew RiceMayuresh G GadgilDouglas A Mitchell

enzyme inhibitionpeptideslinear peptideschemical biologyenzymesprotein synthesismolecular biologybiological chemistryrelevant peptidespeptide synthesisprotein biosynthesisprotein scienceprotein engineeringmodified peptidesbiochemistrybiosynthesis

Peptidic Tryptophan Halogenation by a Promiscuous Flavin‐Dependent Enzyme. Angewandte Chemie International Edition (2025)

Andrew J. RiceMayuresh G. GadgilPaola BisignanoRichard A. SteinHassane S. MchaourabDouglas A. Mitchell

trp14 chlorinationenzyme inhibitionpeptidespeptide synthesisprotein scienceprotein structureinternal trpchemical biologybiomolecular engineeringenzymesprotein synthesismolecular biologybiomoleculesprecursor peptidesbiochemical sciencesprotein engineeringbiochemistrybiosynthesis

Advances in Lasso Peptide Discovery, Biosynthesis, and Function. Trends in Genetics (2024)

Susanna E. BarrettDouglas A. Mitchell

peptide librarypeptidespeptide sciencebiomolecular engineeringdrug discoverylasso peptide discoverycomputational biologyprotein sciencemolecular informaticspeptide synthesis

Biosynthesis of Macrocyclic Peptides With C-Terminal β-Amino-α-Keto Acid Groups by Three Different Metalloenzymes. ACS Central Science (2024)

Dinh T. NguyenLingyang ZhuDanielle L. GrayToby J. WoodsChandrashekhar PadhiKristen M. FlattDouglas A. MitchellWilfred A. van der Donk

peptideschemical biologybiomolecular engineeringmacrocyclic peptidescytochrome p450biological chemistrybioorganometallic chemistrypeptide synthesismodified peptidesbiochemistrybiosynthesis

Computationally Guided Exploration of Borosin Biosynthetic Strategies. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Aileen R. LeeRiley S. CarterAman S. ImaniShravan R. DommarajuGraham A. HudsonDouglas A. MitchellMichael F. Freeman

peptidespeptide scienceprecursor peptidesbiomolecular engineeringmolecular biologystructural bioinformaticsborosin bgcsborosin precursor peptidesprotein designmolecular informaticspeptide synthesisbioinformatics

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Douglas Alan Mitchell

Professor

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Chemistry

School of Chemical Sciences

Department of Chemistry

Douglas Alan Mitchell is currently serving as a College Of Liberal Arts & Sciences Professor at Uiuc.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Douglas Alan Mitchell

UIUC

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Versatile Enzymatic Pathway for Modification of Peptide C-Termini. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Shravan R. DommarajuSanath K. KandyHengqian RenDominic P. LucianoShogo FujikiDavid SarlahHuimin ZhaoJonathan R. ChekanDouglas A. Mitchell

Bps2025 - Lasso Cyclase Functions as a Chaperone That Mediates Peptide Folding and Binding. Biophysical Journal (2025)

Song YinSusanna E. BarrettDouglas A. MitchellDiwakar Shukla

Cell-Free Synthetic Biology for Natural Product Biosynthesis and Discovery. Chemical Society Reviews (2025)

Andrew J. RiceTien T. SwordKameshwari ChenganDouglas A. MitchellNigel J. MounceySimon J. MooreConstance B. Bailey

Lantibiotic-Producing Bacteria Impact Microbiome Resilience and Colonization Resistance. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Mibig 4.0: Advancing Biosynthetic Gene Cluster Curation Through Global Collaboration. Nucleic acids research (2025)

Douglas Alan Mitchell

genome biologybiomedical informaticsfunctional genomicshigh throughput sequencinggeneticsomics datasetsmolecular biologybiotechnology advancemibig 4.0bioinformatics

Peptidic Tryptophan Halogenation by a Promiscuous Flavin-Dependent Enzyme. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Andrew RiceMayuresh G GadgilDouglas A Mitchell

Peptidic Tryptophan Halogenation by a Promiscuous Flavin‐Dependent Enzyme. Angewandte Chemie International Edition (2025)

Andrew J. RiceMayuresh G. GadgilPaola BisignanoRichard A. SteinHassane S. MchaourabDouglas A. Mitchell

Advances in Lasso Peptide Discovery, Biosynthesis, and Function. Trends in Genetics (2024)

Susanna E. BarrettDouglas A. Mitchell

peptide librarypeptidespeptide sciencebiomolecular engineeringdrug discoverylasso peptide discoverycomputational biologyprotein sciencemolecular informaticspeptide synthesis

Biosynthesis of Macrocyclic Peptides With C-Terminal β-Amino-α-Keto Acid Groups by Three Different Metalloenzymes. ACS Central Science (2024)

Dinh T. NguyenLingyang ZhuDanielle L. GrayToby J. WoodsChandrashekhar PadhiKristen M. FlattDouglas A. MitchellWilfred A. van der Donk

peptideschemical biologybiomolecular engineeringmacrocyclic peptidescytochrome p450biological chemistrybioorganometallic chemistrypeptide synthesismodified peptidesbiochemistrybiosynthesis

Computationally Guided Exploration of Borosin Biosynthetic Strategies. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Aileen R. LeeRiley S. CarterAman S. ImaniShravan R. DommarajuGraham A. HudsonDouglas A. MitchellMichael F. Freeman

1
2
3
4
5
14
10 / page