Faculty

Institution

Unit

Venue

David J Shapiro

Professor of Biochemistry

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

David J Shapiro is currently serving as a College Of Liberal Arts & Sciences Professor of Biochemistry at Uiuc.

Honors

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Experiences

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Education

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David J Shapiro

UIUC

Professor of Biochemistry

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hormonal receptor cell biology gene expression molecular cell biology endocrinology cancer cells transcription (biology) endocrine-related cancers molecular cancer breast cancer genetics molecular biology receptors therapeutic targets nucleic acids endocrine research cancer biology developmental biology transcription factors oncogenes reproductive biology breast oncology estrogen receptor molecular and cellular biology cell death reproductive hormones transcription regulation endocrine mechanisms biological chemistry anti-cancer agents gene regulation apoptosis molecular metabolism cancer discovery molecular physiology reproductive science liver physiology ovarian hormones cell metabolism molecular regulation steroid metabolism structural molecular biology protein science rna biology nucleic acid chemistry unfolded protein response estrogen receptor α lipoprotein metabolism rna processing protein expression cancer growth dna bending signaling pathways receptor (biochemistry) estrogen induction estrogen response element human estrogen receptor metabolic regulation dna analysis gene function cell regulation hmg-coa reductase proteinase inhibitor 9 mrna stability oncogenic agent protein biosynthesis cancer genetics nucleic acid biomarkers cell proliferation vitellogenin mrna nuclear estrogen receptor estrogen response elements xenopus estrogen receptor virus gene rat liver cholesterol feeding pharmacology cell signaling drug discovery molecular neurodegeneration signal transduction pathway analysis cell death pathways pharmacological research

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 5626: Exploring a New Therapeutic Strategy Through Hyperactivation of the Unfolded Protein Response Pathway in Bone Cancer Treatment. Cancer Research (2025)

Yoongyeong LeeMichael MulliganBrooke BouwensJenny DrnevichKeith BaileyMichael SpinellaDavid ShapiroPaul HergenrotherTimothy Fan

metastasisradiation oncologytrpm4 expressiontherapeutic targetsoncologybreast canceroncogenescancer cellscancer treatmentestrogen receptor alphacancer biologytumor biologybone researchbone cancer cellscell biology

A Necrosis Inducer Promotes an Immunogenic Response and Destroys Ovarian Cancers in Mouse Xenografts and Patient Ascites Organoids. Cancer Letters (2025)

Darjan DurakiMusarrat JabeenChengjian MaoLawrence WangSantanu GhoshXinyi DaiJunyao ZhuMatthew W BoudreauErik R NelsonPaul J HergenrotherGeorgina ChengDavid J Shapiro

immunologycell deathendocrine-related cancersnecrosis inducergynecologic oncologyovarian hormonespatient ascites organoidsapoptosismouse xenograftscancer cellsgynecologytumor biologyovarian cancerinflammation

Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice. ACS Central Science (2025)

Michael P. MulliganMatthew W. BoudreauBrooke A. BouwensYoongyeong LeeHunter W. CarrellJunyao ZhuSpyro MoussesDavid J. ShapiroErik R. NelsonTimothy M. FanPaul J. Hergenrother

estrogen receptor αendocrine-related cancerspharmacologyradiation oncologytherapeutic targetsanti-cancer agentsoncologybreast canceroncogenescancer cellscancer treatmentsingle dosetumor biologybreast oncology

7065 Eradication of Metastatic Er-Positive Breast, Ovarian, Endometrial and Lung Cancer in Mouse Xenografts and Patient Derived Organoids. Journal of the Endocrine Society (2024)

D J ShapiroD DurakiS GhoshJ ZhuC MaoJ KimM JabeenM W BoudreauM P MulliganR RomeroY HanJ ZhangE R NelsonO OlopadeG ChangP J Hergenrother

endocrine-related cancersmetastasisradiation oncologymolecular cancergynecologic oncologytumor suppressorsbreast cancermouse xenograftsoncogenescancer cellslung cancerpatient derived organoidscancer biologytumor biologyovarian cancercell biology

Abstract 2210 to Die or Not to Die: Controlling Death in Breast and Ovarian Cancer Cells With a Novel Pathway Regulating Anticancer Drug. Journal of Biological Chemistry (2024)

Elaine WeiDavid ShapiroJunyao ZhuErik NelsonSantanu GoshDarjan Duraki

immunologycell deathfgd3 protein levelsabstract 2210therapeutic targetsanti-cancer agentsapoptosisbreast cancerfgd3 knockout protectscancer cellscancer biologytumor biologycell biology

Abstract 5995: How FDA-Approved Drug, Aprepitant, Induces Immunogenic Death of Cancer Cells. Cancer Research (2024)

Xinyi DaiJunyao ZhuSofia PerryQianjin JiangDavid J. Shapiro

immunologycell deathpharmacologycell signalingmolecular cancerimmune checkpoint inhibitorscancer immunotherapytherapeutic targetsanti-cancer agentsapoptosisimmunoeditingoncogenescancer cellsmedicinal researchmembrane rupturetumor biologyimmunotherapy

Abstract 6000: A Novel Pathway Controlling Anticancer Drug Induced Immunogenic Cell Death. Cancer Research (2024)

Junyao ZhuSantanu GhoshDarjan DurakiMatthew BoudreauMusarrat JabeenChengjian MaoBen H. ParkGeorgina ChengErik R. NelsonPaul J. HergenrotherDavid J. Shapiro

immunologycell deathmetastasisendocrine-related cancersmolecular cancergynecologic oncologyabstract 6000cancer immunotherapyapoptosisoncogenescancer cellsestrogen receptor alphacancer biologytumor biologyovarian cancermembrane rupturecell biology

Spatiotemporal Control of Inflammatory Lytic Cell Death Through Optogenetic Induction of Ripk3 Oligomerization. Journal of Molecular Biology (2024)

Teak-Jung OhVishnu KrishnamurthyJeong Won HanJunyao ZhuZayn BegAmna MehfoozBryan GworekDavid J. ShapiroKai Zhang

optogeneticssignaling pathwayscell deathgene expressionplasma membrane rupturecell signalingreceptor tyrosine kinasesmolecular cell biologymolecular biologyspatial light modulatorcell biology

Abstract 522: Selective Estrogen Receptor A-Upr Activators (Sera): A Novel Class of Small Molecules That Eradicate Estrogen Receptor Positive Tumors. Cancer Research (2023)

Michael P. MulliganMatthew W. BoudreauDavid J. ShapiroTimothy M. FanPaul J. HergenrotherKerry BarnhartDavid AzorsaJeff KieferSpyro Mousses

endocrine-related cancerspharmacologymolecular cancercancer discoverytherapeutic targetsabstract 522anti-cancer agentsbreast oncologybreast canceroncogenescancer cellsestrogen receptor alphatumor biologycell biology

Abstract P6-10-01: The Executioner Protein for Immunogenic Anticancer Drug-Induced Necrosis in Er Positive Breast Cancer is Transient Receptor Potential Melastatin Member 4. Cancer Research (2023)

Santanu GhoshRachel YangDarjan DurakiJi Eun KimJunyao ZhuMara LivezeyMatthew BoudreauBen H. ParkTImothy FanErik R. NelsonPaul J. HergenrotherDavid J. Shapiro

immunologytumor targetingcell deathmetastasistrpm4 increase sensitivitymolecular cancertherapeutic targetstrpm4 pathwayanti-cancer agentsbreast oncologytrpm4 knockoutbreast cancercancer cellscancer biologytumor biologycell biology

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David J Shapiro

Professor of Biochemistry

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

David J Shapiro is currently serving as a College Of Liberal Arts & Sciences Professor of Biochemistry at Uiuc.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

David J Shapiro

UIUC

Professor of Biochemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 5626: Exploring a New Therapeutic Strategy Through Hyperactivation of the Unfolded Protein Response Pathway in Bone Cancer Treatment. Cancer Research (2025)

Yoongyeong LeeMichael MulliganBrooke BouwensJenny DrnevichKeith BaileyMichael SpinellaDavid ShapiroPaul HergenrotherTimothy Fan

A Necrosis Inducer Promotes an Immunogenic Response and Destroys Ovarian Cancers in Mouse Xenografts and Patient Ascites Organoids. Cancer Letters (2025)

Darjan DurakiMusarrat JabeenChengjian MaoLawrence WangSantanu GhoshXinyi DaiJunyao ZhuMatthew W BoudreauErik R NelsonPaul J HergenrotherGeorgina ChengDavid J Shapiro

Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice. ACS Central Science (2025)

Michael P. MulliganMatthew W. BoudreauBrooke A. BouwensYoongyeong LeeHunter W. CarrellJunyao ZhuSpyro MoussesDavid J. ShapiroErik R. NelsonTimothy M. FanPaul J. Hergenrother

7065 Eradication of Metastatic Er-Positive Breast, Ovarian, Endometrial and Lung Cancer in Mouse Xenografts and Patient Derived Organoids. Journal of the Endocrine Society (2024)

D J ShapiroD DurakiS GhoshJ ZhuC MaoJ KimM JabeenM W BoudreauM P MulliganR RomeroY HanJ ZhangE R NelsonO OlopadeG ChangP J Hergenrother

Abstract 2210 to Die or Not to Die: Controlling Death in Breast and Ovarian Cancer Cells With a Novel Pathway Regulating Anticancer Drug. Journal of Biological Chemistry (2024)

Elaine WeiDavid ShapiroJunyao ZhuErik NelsonSantanu GoshDarjan Duraki

immunologycell deathfgd3 protein levelsabstract 2210therapeutic targetsanti-cancer agentsapoptosisbreast cancerfgd3 knockout protectscancer cellscancer biologytumor biologycell biology

Abstract 5995: How FDA-Approved Drug, Aprepitant, Induces Immunogenic Death of Cancer Cells. Cancer Research (2024)

Xinyi DaiJunyao ZhuSofia PerryQianjin JiangDavid J. Shapiro

Abstract 6000: A Novel Pathway Controlling Anticancer Drug Induced Immunogenic Cell Death. Cancer Research (2024)

Junyao ZhuSantanu GhoshDarjan DurakiMatthew BoudreauMusarrat JabeenChengjian MaoBen H. ParkGeorgina ChengErik R. NelsonPaul J. HergenrotherDavid J. Shapiro

Spatiotemporal Control of Inflammatory Lytic Cell Death Through Optogenetic Induction of Ripk3 Oligomerization. Journal of Molecular Biology (2024)

Teak-Jung OhVishnu KrishnamurthyJeong Won HanJunyao ZhuZayn BegAmna MehfoozBryan GworekDavid J. ShapiroKai Zhang

optogeneticssignaling pathwayscell deathgene expressionplasma membrane rupturecell signalingreceptor tyrosine kinasesmolecular cell biologymolecular biologyspatial light modulatorcell biology

Abstract 522: Selective Estrogen Receptor A-Upr Activators (Sera): A Novel Class of Small Molecules That Eradicate Estrogen Receptor Positive Tumors. Cancer Research (2023)

Michael P. MulliganMatthew W. BoudreauDavid J. ShapiroTimothy M. FanPaul J. HergenrotherKerry BarnhartDavid AzorsaJeff KieferSpyro Mousses

Abstract P6-10-01: The Executioner Protein for Immunogenic Anticancer Drug-Induced Necrosis in Er Positive Breast Cancer is Transient Receptor Potential Melastatin Member 4. Cancer Research (2023)

Santanu GhoshRachel YangDarjan DurakiJi Eun KimJunyao ZhuMara LivezeyMatthew BoudreauBen H. ParkTImothy FanErik R. NelsonPaul J. HergenrotherDavid J. Shapiro

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