Dinesh Aryal

Edward Via College of Osteopathic Medicine

Affiliations

Center For One Health Research

Department Of Biomedical Affairs And Research

Department Of Community And Rural Medicine

Department Of Family Medicine, Sports Medicine, Osteopathic Manipulative Medicine

Edward Via College of Osteopathic Medicine

Pharmacology

Laboratory Of Molecular Pharmacology And Toxicology

NoneDinesh Aryal is currently serving as a Center For One Health Research faculty at Edward Via College of Osteopathic Medicine.

Honors

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Experiences

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Education

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Dinesh Aryal

Edward Via College of Osteopathic Medicine

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pharmacology biochemistry hypertension enzyme inhibition renal pathophysiology chronic metabolic acidosis drug discovery redox biology pharmacotherapy medicinal research clinical lipidology vascular biology antioxidants metabolic syndrome free radical biology tumor targeting anti-cancer agents skin cancer secondary metabolism renal function intrarenal angiotensin ii chronic acidotic conditions medicine radiation oncology medicinal chemistry enzymes tumor biology synthetic biology diabetes obesity molecular cancer drug analysis dermatological treatment cellular physiology molecular physiology circulatory physiology enzyme catalysis derivative (chemistry) hyperlipidemia metabolic control reactive oxygen species metabolic disorders experimental pharmacology acute kidney injury clinical dermatology cancer treatment endocrine hypertension adrenal glands adrenal disease human physiology disease physiology potential anti-skin cancer antioxidant agents substituted pyrazole derivatives blood pressure alterations renal proximal tubule local mediators acid-base balance rho-kinase inhibitor kidney injury pyrazolone derivatives anti-skin cancer in-silico characterization tyrosinase inhibitory agents

Notable Scholarly Works

Notable Federal Grants

Collaborators

Renal Heme-Oxygenase-1 Mediated Overexpression of Tubular Na+/H+ Exchanger 3 Promotes Hypertension During Chronic Metabolic Acidosis in Experimental Rats (Abstract Id: 231890). Journal of Pharmacology and Experimental Therapeutics (2026)

Rho-Kinase Inhibitor Attenuates Kidney Injury via Inos Mediated Mechanisms During Chronic Metabolic Acidosis. Journal of Pharmacology and Experimental Therapeutics (2024)

Dinesh AryalDan LuuKeith E. Jackson

drug metabolismacute kidney injurypharmacologyfree radical biologyrenal pathophysiologyrenal functionurologychronic kidney diseasesecondary metabolismoxidative stressrho-kinase inhibitormetabolic syndromeredox biologynephrologymedicinal researchkidney injurybiomolecular engineeringinflammationchronic metabolic acidosisexperimental pharmacologyenzyme inhibition

Intrarenal Angiotensin II Mediated Rock1 Activation Promotes Hypertension During Chronic Acidotic Conditions. Physiology (2023)

Dinesh AryalKeith Jackson

human physiologypharmacologyendocrine hypertensioncardiovascular diseasemolecular physiologycirculatory physiologymechanobiologysystems biologyadrenal diseaseadrenal glandsintrarenal angiotensin iihypertensionvascular biologydisease physiologyphysiologyclinical lipidologyinflammationendocrinologychronic acidotic conditionscellular physiology

Synthesis, in Silico Modelling, and in Vitro Biological Evaluation of Substituted Pyrazole Derivatives as Potential Anti-Skin Cancer, Anti-Tyrosinase, and Antioxidant Agents. Journal of Enzyme Inhibition and Medicinal Chemistry (2023)

Samuel T. BoatengTithi RoyKara TorreyUchechi OwunnaSergette Banang-MbeumiDavid BasnetEleonora NieddaAlexis D. AlexanderDenzel El HageSiriki AtchimnaiduBolni Marius NagaloDinesh AryalAnn FindleyNavindra P. SeeramTatiana EfimovaMario SechiRonald A. HillHang MaJean Christopher ChamcheuSiva Murru

medicineenzyme catalysispharmacologypotential anti-skin cancersubstituted pyrazole derivativestumor biologyenzymesenzyme inhibitionmedicinal chemistryderivative (chemistry)drug discoveryanti-cancer agentsradiation oncologymolecular cancerredox biologyantioxidant agentstumor targetingmedicinal researchsynthetic biologyskin cancerpharmacotherapy

590 Biological and In-Silico Characterization of Pyrazole and Pyrazolone Derivatives: Identifies Novel Anti-Skin Cancer, Antioxidant and Tyrosinase Inhibitory Agents. Journal of Investigative Dermatology (2022)

S.T. BoatengT. RoyK. TorreyS. Banang-MbeumiD. AryalS. MurruH. MaJ.C. Chamcheu

cancer immunotherapyanti-skin cancerdrug analysispharmacologytherapeutic targetsdermatological treatmentenzyme inhibitiontyrosinase inhibitory agentsoncologycancer researchcancer treatmentclinical dermatologyin-silico characterizationdrug discoveryanti-cancer agentsimmunologyantioxidantstumor targetingpyrazolone derivativesdermatologyskin cancerpharmacotherapy

Renal Pathophysiological Changes During Chronic Metabolic Acidosis Associated Increased Blood Pressure. The FASEB Journal (2022)

Dinesh AryalKeith E. Jackson

metabolismchronic metabolic acidosisbiochemistryphysiologyrenal pathophysiologyrenal pathophysiological changes

Abstract 9359: Intrarenal Release of Superoxide Act Synergistically With Interstitial Angiotensin II to Promote Hypertension During Chronic Acidotic Conditions. Circulation (2021)

Dinesh AryalJeanChristophe ChamcheuKeith E JACKSON

chronic acidotic conditionsinterstitial angiotensin iihypertensionphysiologysuperoxide actintrarenal release

Association of Acid-Base Balance in the Renal Proximal Tubule and Blood Pressure Alterations: Potential Role of Local Mediators. Journal of Biosciences and Medicines (2020)

Dinesh AryalKeith E. Jackson

renal proximal tubuleblood pressure alterationsbiochemistryacid-base balancenephrologyrenal pathophysiologylocal mediatorsrenal function

Chronic Metabolic Acidosis Elicits Hypertension via Upregulation of Intrarenal Angiotensin II and Induction of Oxidative Stress. Antioxidants (2020)

Dinesh AryalTithi RoyJean Christopher ChamcheuKeith E. Jackson

diabetesreactive oxygen speciesfree radical biologycardiovascular diseasesecondary metabolismoxidative stressmetabolic disordersmetabolic syndromeintrarenal angiotensin iihypertensionbiochemistryvascular biologyantioxidantsobesityglobal healthclinical lipidologybiomolecular engineeringchronic metabolic acidosishyperlipidemiametabolic control