Faculty

Institution

Unit

Venue

Diane Lipscombe

Professor

Brown University

Affiliations

Division of Biology and Medicine

Molecular Biology, Cell Biology, and Biochemistry

Warren Alpert Medical School

Molecular Biology, Cell Biology, & Biochemistry

Neuroscience

Diane Lipscombe is currently serving as a Division Of Biology And Medicine Professor at Brown University.

Honors

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Experiences

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Education

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Diane Lipscombe

Brown University

Professor

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neuroscience neurophysiology electrophysiology neurology molecular neuroscience signal transduction systems neuroscience pharmacology cellular neurobiology physiology neurochemistry alternative splicing neurotransmission neuropharmacology molecular neurobiology cell signaling neuroanatomy neural science brain science molecular physiology bioluminescence protein science peripheral nervous system n-type calcium channels pain research cellular physiology affective neuroscience mammalian biology brain circuitry clinical neuroscience calcium channels genome biology molecular cell biology animal physiology neurodynamics catalyst activation pain mechanism neuromodulation (medicine) neurotransmitters neuroprotection rna biology psychiatric genetics physiological research amyotrophic lateral sclerosis neuronal calcium channels hyperpolarized membrane potentials l-type calcium channels sympathetic neurons functional diversity a-adrenergic inhibition pain medicine material research applied pharmacology pharmaceutics peptides nucleic acids ornithology tissue imaging transient imaging neuropathic pain medical genetics rna processing translational physiology membrane transport neural mechanisms functional regulation remedial action cellular pharmacology tissue physiology multiple types selective modulation l-type channels sympathetic neurotransmitter release cytosolic calcium transients growth cones spatial distribution chronic pain

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Efficient Opto- and Chemogenetic Control in a Single Molecule Driven by Fret-Modified Bioluminescence. Neurophotonics (2024)

Andreas BjörefeldtJeremy MurphyEmmanuel L CrespoGerard G LambertMansi PrakashEbenezer C IkefuamaNina FriedmanTariq M BrownDiane LipscombeChristopher I MooreUte HochgeschwenderNathan C Shaner

optogeneticsbiophysicsfret-modified bioluminescencesingle moleculesneurosciencebioluminescence

Engineering Luminopsins With Improved Coupling Efficiencies. Neurophotonics (2024)

Ashley N. SlavieroNipun GorantlaJacob SimkinsEmmanuel L. CrespoEbenezer C. IkefuamaMaya O. TreeMansi PrakashAndreas BjörefeldtLauren M. BarnettGerard G. LambertDiane LipscombeChristopher I. MooreNathan C. ShanerUte Hochgeschwender

engineering luminopsinsbiophysicsbiomolecular engineeringneurosciencephotonics

Interleukin-1α Links Peripheral Cav2.2 Channel Activation to Rapid Adaptive Increases in Heat Sensitivity in Skin. Scientific Reports (2024)

Anne-Mary N. SalibMeredith J. CraneSang Hun LeeBrian J. WaingerAmanda M. JamiesonDiane Lipscombe

immunologyheat sensitivitydermatologypharmacologycell signalingcytokinesadaptive immune systemimmune responsescutaneous biologyinflammation

Peripheral Ca V 2.2 Channels in Skin Regulate Prolonged Heat Hypersensitivity During Neuroinflammation. eNeuro (2024)

Anne-Mary N. SalibMeredith J. CraneAmanda M. JamiesonDiane Lipscombe

physiologyneuroinflammationperipheral nervous systeminflammationskin regulateheat hypersensitivityhypersensitivity

A Bioluminescent Activity Dependent (Blade) Platform for Converting Neuronal Activity to Photoreceptor Activation. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Emmanuel L. CrespoAkash PalMansi PrakashAlexander D. SilvagnoliZohair ZaidiManuel Gomez-RamirezMaya O. TreeNathan C. ShanerDiane LipscombeChristopher MooreUte Hochgeschwender

cognitive neuroscienceneuronal activitybiophysicsbioluminescent activity dependentneuroscienceneurophysiologybioluminescence

A New Highly Efficient Molecule for Both Optogenetic and Chemogenetic Control Driven by Fret Amplification of Bioluminescence. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Andreas BjörefeldtJeremy MurphyEmmanuel L CrespoGerard G LambertMansi PrakashEbenezer C IkefuamaNina FriedmanTariq M BrownDiane LipscombeChristopher I MooreUte HochgeschwenderNathan C Shaner

optogeneticsfret amplificationchemogenetic controlmolecular biologybioluminescence

Cablam! a High-Contrast Bioluminescent Ca 2+ Indicator Derived From an Engineered Oplophorus Gracilirostris Luciferase. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Gerard G. LambertEmmanuel L. CrespoJeremy MurphyDaniela BoassaSelena LuongDmitrijs CelinskisStephanie VennDaniel K. NguyenJunru HuBrittany SprecherMaya O. TreeRichard OrcuttDaniel HeydariAidan B. BellAlbertina Torreblanca-ZancaAli HakimiDiane LipscombeChristopher I. MooreUte HochgeschwenderNathan C. Shaner

catalyst activationbiological engineeringbiochemical engineeringmolecular microbiologyapplied microbiologyenvironmental microbiologyhigh-contrast bioluminescentbiomolecular engineeringcalcium aluminateluminescencesynthetic biologybiochemistrybioluminescence

Towards a Brighter Constellation: Multi-Organ Neuroimaging of Neural and Vascular Dynamics in the Spinal Cord and Brain. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Dmitrijs CelinskisChristopher J. BlackJeremy MurphyAdriel Barrios-AndersonNina FriedmanNathan C. ShanerCarl SaabManuel Gomez-RamirezDiane LipscombeDavid A. BortonChristopher I. Moore

cognitive neuroscienceneurologyneuroimagingsystems biologybrain imagingvascular dynamicsspinal cordsystems neurosciencemulti-organ neuroimagingneuroscienceneuroanatomy

Up-Regulation of Cholesterol Synthesis Pathways and Limited Neurodegeneration in a Knock-in Sod1 Mutant Mouse Model of Als. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Janice A. DominovLaura A. MadiganJoshua P. WhittKaterina L. RademacherKristin M. WebsterHesheng ZhangHaruhiko BannoSiqi TangYifan ZhangNicholas WightmanEmma M. ShychuckJohn PageAlexandra WeissKaren KellyAlper KucukuralMichael H. BrodskyAlexander JaworskiJustin R. FallonDiane LipscombeRobert H. Brown

cholesterol synthesis pathwaysgeneticslipid synthesisknockout micemolecular biologymolecular neurodegenerationalzheimer's diseasepathway analysisneuroscienceamyotrophic lateral sclerosis

Ω-Phonetoxins Inhibit Voltage-Gated Calcium Ca V 2.2 Ion Channel Splice Isoforms of Dorsal Root Ganglia. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Célio Castro-JuniorMarcus Vinícius GomezMarcia Helena BorgesDiane LipscombeArturo Andrade

neurologybiophysicselectrophysiologydorsal root gangliaredox biologymolecular neurosciencebiological functionmembrane biologybioelectrochemistrysignal transductionprotein sciencecellular neurobiologyneuroscienceneurophysiologymolecular physiology

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Diane Lipscombe

Professor

Brown University

Affiliations

Division of Biology and Medicine

Molecular Biology, Cell Biology, and Biochemistry

Warren Alpert Medical School

Molecular Biology, Cell Biology, & Biochemistry

Neuroscience

Diane Lipscombe is currently serving as a Division Of Biology And Medicine Professor at Brown University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Diane Lipscombe

Brown University

Professor

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Efficient Opto- and Chemogenetic Control in a Single Molecule Driven by Fret-Modified Bioluminescence. Neurophotonics (2024)

Andreas BjörefeldtJeremy MurphyEmmanuel L CrespoGerard G LambertMansi PrakashEbenezer C IkefuamaNina FriedmanTariq M BrownDiane LipscombeChristopher I MooreUte HochgeschwenderNathan C Shaner

optogeneticsbiophysicsfret-modified bioluminescencesingle moleculesneurosciencebioluminescence

Engineering Luminopsins With Improved Coupling Efficiencies. Neurophotonics (2024)

engineering luminopsinsbiophysicsbiomolecular engineeringneurosciencephotonics

Interleukin-1α Links Peripheral Cav2.2 Channel Activation to Rapid Adaptive Increases in Heat Sensitivity in Skin. Scientific Reports (2024)

Anne-Mary N. SalibMeredith J. CraneSang Hun LeeBrian J. WaingerAmanda M. JamiesonDiane Lipscombe

immunologyheat sensitivitydermatologypharmacologycell signalingcytokinesadaptive immune systemimmune responsescutaneous biologyinflammation

Peripheral Ca V 2.2 Channels in Skin Regulate Prolonged Heat Hypersensitivity During Neuroinflammation. eNeuro (2024)

Anne-Mary N. SalibMeredith J. CraneAmanda M. JamiesonDiane Lipscombe

physiologyneuroinflammationperipheral nervous systeminflammationskin regulateheat hypersensitivityhypersensitivity

A Bioluminescent Activity Dependent (Blade) Platform for Converting Neuronal Activity to Photoreceptor Activation. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Emmanuel L. CrespoAkash PalMansi PrakashAlexander D. SilvagnoliZohair ZaidiManuel Gomez-RamirezMaya O. TreeNathan C. ShanerDiane LipscombeChristopher MooreUte Hochgeschwender

cognitive neuroscienceneuronal activitybiophysicsbioluminescent activity dependentneuroscienceneurophysiologybioluminescence

A New Highly Efficient Molecule for Both Optogenetic and Chemogenetic Control Driven by Fret Amplification of Bioluminescence. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Andreas BjörefeldtJeremy MurphyEmmanuel L CrespoGerard G LambertMansi PrakashEbenezer C IkefuamaNina FriedmanTariq M BrownDiane LipscombeChristopher I MooreUte HochgeschwenderNathan C Shaner

optogeneticsfret amplificationchemogenetic controlmolecular biologybioluminescence

Cablam! a High-Contrast Bioluminescent Ca 2+ Indicator Derived From an Engineered Oplophorus Gracilirostris Luciferase. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Towards a Brighter Constellation: Multi-Organ Neuroimaging of Neural and Vascular Dynamics in the Spinal Cord and Brain. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Dmitrijs CelinskisChristopher J. BlackJeremy MurphyAdriel Barrios-AndersonNina FriedmanNathan C. ShanerCarl SaabManuel Gomez-RamirezDiane LipscombeDavid A. BortonChristopher I. Moore

cognitive neuroscienceneurologyneuroimagingsystems biologybrain imagingvascular dynamicsspinal cordsystems neurosciencemulti-organ neuroimagingneuroscienceneuroanatomy

Up-Regulation of Cholesterol Synthesis Pathways and Limited Neurodegeneration in a Knock-in Sod1 Mutant Mouse Model of Als. bioRxiv (Cold Spring Harbor Laboratory) (2023)

cholesterol synthesis pathwaysgeneticslipid synthesisknockout micemolecular biologymolecular neurodegenerationalzheimer's diseasepathway analysisneuroscienceamyotrophic lateral sclerosis

Ω-Phonetoxins Inhibit Voltage-Gated Calcium Ca V 2.2 Ion Channel Splice Isoforms of Dorsal Root Ganglia. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Célio Castro-JuniorMarcus Vinícius GomezMarcia Helena BorgesDiane LipscombeArturo Andrade

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