Faculty

Institution

Unit

Venue

Dennis Peffley

Philadelphia College of Osteopathic Medicine

Affiliations

Bio-Medical Sciences (PCOM Georgia)

Bio-Medical Sciences (PCOM South Georgia)

Department Of Biomedical Sciences

Department Of Physiology And Pharmacology

Philadelphia College of Osteopathic Medicine

NoneDennis Peffley is currently serving as a Bio-Medical Sciences (Pcom Georgia) faculty at Philadelphia College of Osteopathic Medicine.

Honors

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Experiences

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Education

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Dennis Peffley

Philadelphia College of Osteopathic Medicine

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cell biology biochemistry tumor biology molecular biology pharmacology cancer cells metabolic pathways cancer research cell signaling signal transduction gene expression dna repair molecular and cellular biology molecular metabolism cell metabolism oncogenes nucleic acids molecular cell biology enzyme inhibition cancer biology signaling pathways perillyl alcohol biological chemistry natural product research cell death medicinal research plant cells molecular diagnostics genome biology educational strategies educational assessment oncogenic agent metabolic remodeling steroid metabolism cell regulation tumor suppressors gene regulation transcription regulation protein biosynthesis aldo-keto reductase protein synthesis chemoprevention strategies plant hormones dna sequencing gene characterization molecular pathology gene deletion data on-line testing intelligent tutoring systems invasion biology perineural invasion cell migration sterol‐independent regulation htert-mtor-raptor protein complex phytochemical perillyl alcohol eif4e/eif4g interactions human tumor cells telomerase activity isoprenoid perillyl alcohol prostate cancer cells telomerase reverse transcriptase eif4e-overexpression imparts rapamycin-mediated regulation reductase synthesis coenzyme a tumor cells complementary molecular approaches

Notable Scholarly Works

Notable Federal Grants

Collaborators

Optimizing Student Use of Quiz Questions as a Learning Tool. The FASEB Journal (2019)

educational strategieseducationlearning sciencesquiz questionsintelligent tutoring systemson-line testinglanguageeducational assessmenteducational technology

Disruption of an Htert–Mtor–Raptor Protein Complex by a Phytochemical Perillyl Alcohol and Rapamycin. Molecular and Cellular Biochemistry (2013)

natural product researchenzymesbiochemistrychemical biologymolecular biologybiological chemistryhtert–mtor–raptor protein complexphytochemical perillyl alcoholenzyme inhibitionbiosynthesis

Eif4E-Overexpression Imparts Perillyl Alcohol and Rapamycin-Mediated Regulation of Telomerase Reverse Transcriptase. Experimental Cell Research (2013)

eif4e-overexpression impartsrapamycin-mediated regulationnucleic acidscell biologytranscription factorsgene regulationdna replicationmolecular cell biologytranscription (biology)molecular biologytranscription regulationtelomerase reverse transcriptasegene expressiondna repair

Perillyl Alcohol and Rapamycin‐Mediated Inhibition of Migration and Invasion. The FASEB Journal (2013)

Tabetha SundinPeter MollicaDennis PeffleyPatricia Hentosh

perillyl alcoholtumor biologyimmunologyrapamycin-mediated inhibitionperineural invasionbiological invasionspharmacologyinvasion biologyenzyme inhibitioncell migration

Plant-Derived Isoprenoids Mediate Regulation of Mtor Signaling in Tumor Cells. (2012)

molecular and cellular biologyoncogenescancer cellstumor biologyplant hormonescell signalingcell biologysignaling pathwaysbiochemistryplant cellschemoprevention strategiestumor cellssignal transduction

The Isoprenoid Perillyl Alcohol Inhibits Telomerase Activity in Prostate Cancer Cells. Biochimie (2012)

Tabetha SundinDennis M. PeffleyDavid GauthierPatricia Hentosh

neurologytumor biologyprostate cancer cellsmedicinal researchprostate cancerpharmacologytelomerase activityurologyoncologyisoprenoid perillyl alcohol

Xeroderma Pigmentosum Variant: Complementary Molecular Approaches to Detect a 13 Base Pair Deletion in the Dna Polymerase Eta Gene. Experimental and Molecular Pathology (2011)

gene deletion datadna sequencingmutagenesis (molecular biology technique)xeroderma pigmentosum variantbase pair deletionmolecular pathologynucleic acidscomplementary molecular approachesgenomicsgenome biologymolecular geneticsmolecular diagnosticsgene characterizationmolecular biologydna repairgenetics

Perillyl Alcohol and Genistein Differentially Regulate Pkb/Akt and 4E-Bp1 Phosphorylation as Well as Eif4E/Eif4G Interactions in Human Tumor Cells. Archives of Biochemistry and Biophysics (2007)

oncogenesperillyl alcoholcancer cellstumor biologyeif4e/eif4g interactionshuman tumor cellscell deathcell signalingcell biologysignaling pathwaysbiochemistrycancer researchtumor suppressorspharmacologysignal transductioncell regulationcancer biology

Proto Oncogene/Eukaryotic Translation Initiation Factor (Eif) 4E Attenuates Mevalonate‐Mediated Regulation of 3‐Hydroxy‐3‐Methylglutaryl Coenzyme a (Hmg‐Coa) Reductase Synthesis. Molecular Carcinogenesis (2004)

molecular and cellular biologymolecular metabolismaldo-keto reductasecell biologymetabolic pathwaysreductase synthesisbiochemistrycell metabolismcoenzyme amolecular cell biologyprotein synthesismolecular biologygene expressionprotein biosynthesis

Sterol‐Independent Regulation of 3‐Hydroxy‐3‐Methylglutaryl Coenzyme a Reductase in Tumor Cells. Molecular Carcinogenesis (2001)

lipidssterol‐independent regulationtumor biologymolecular metabolismcell biologymetabolic pathwaysbiochemistrycell metabolismcancer researchoncogenic agentmetabolic remodelingcancer cellssteroid metabolismcancer biology

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Dennis Peffley

Philadelphia College of Osteopathic Medicine

Affiliations

Bio-Medical Sciences (PCOM Georgia)

Bio-Medical Sciences (PCOM South Georgia)

Department Of Biomedical Sciences

Department Of Physiology And Pharmacology

Philadelphia College of Osteopathic Medicine

NoneDennis Peffley is currently serving as a Bio-Medical Sciences (Pcom Georgia) faculty at Philadelphia College of Osteopathic Medicine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Dennis Peffley

Philadelphia College of Osteopathic Medicine

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Optimizing Student Use of Quiz Questions as a Learning Tool. The FASEB Journal (2019)

educational strategieseducationlearning sciencesquiz questionsintelligent tutoring systemson-line testinglanguageeducational assessmenteducational technology

Disruption of an Htert–Mtor–Raptor Protein Complex by a Phytochemical Perillyl Alcohol and Rapamycin. Molecular and Cellular Biochemistry (2013)

natural product researchenzymesbiochemistrychemical biologymolecular biologybiological chemistryhtert–mtor–raptor protein complexphytochemical perillyl alcoholenzyme inhibitionbiosynthesis

Eif4E-Overexpression Imparts Perillyl Alcohol and Rapamycin-Mediated Regulation of Telomerase Reverse Transcriptase. Experimental Cell Research (2013)

Perillyl Alcohol and Rapamycin‐Mediated Inhibition of Migration and Invasion. The FASEB Journal (2013)

Tabetha SundinPeter MollicaDennis PeffleyPatricia Hentosh

perillyl alcoholtumor biologyimmunologyrapamycin-mediated inhibitionperineural invasionbiological invasionspharmacologyinvasion biologyenzyme inhibitioncell migration

Plant-Derived Isoprenoids Mediate Regulation of Mtor Signaling in Tumor Cells. (2012)

The Isoprenoid Perillyl Alcohol Inhibits Telomerase Activity in Prostate Cancer Cells. Biochimie (2012)

Tabetha SundinDennis M. PeffleyDavid GauthierPatricia Hentosh

neurologytumor biologyprostate cancer cellsmedicinal researchprostate cancerpharmacologytelomerase activityurologyoncologyisoprenoid perillyl alcohol

Xeroderma Pigmentosum Variant: Complementary Molecular Approaches to Detect a 13 Base Pair Deletion in the Dna Polymerase Eta Gene. Experimental and Molecular Pathology (2011)

Perillyl Alcohol and Genistein Differentially Regulate Pkb/Akt and 4E-Bp1 Phosphorylation as Well as Eif4E/Eif4G Interactions in Human Tumor Cells. Archives of Biochemistry and Biophysics (2007)

Sterol‐Independent Regulation of 3‐Hydroxy‐3‐Methylglutaryl Coenzyme a Reductase in Tumor Cells. Molecular Carcinogenesis (2001)

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10 / page