Faculty

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Venue

Ilia G Denisov

Research Scientist

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Ilia G Denisov is currently serving as a College Of Liberal Arts & Sciences Research Scientist at Uiuc.

Honors

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Experiences

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Education

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Ilia G Denisov

UIUC

Research Scientist

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biochemistry enzymes biophysical chemistry molecular metabolism drug metabolism biological chemistry molecular biology biochemical sciences chemical biology redox biology enzyme inhibition biophysics pharmacology heme degradation molecular biophysics cell metabolism protein science membrane proteins membrane biology molecular pharmacology biological macromolecules structural molecular biology biomolecular structure nanodisc pharmacological research redox chemistry biochemical genetics biomolecules steroid metabolism biochemical interaction structure-function enzyme kinetics cytochrome p450 membrane science molecular science vibrational spectroscopy transition metal chemistry enzyme catalysis heme transport proteinlipid interaction aldehyde dehydrogenase reaction intermediates protein x-ray crystallography drug targets cellular enzymology hormonal receptor cytochrome p450 3a4 membrane structure membrane systems heme signaling reactive oxygen species heme homeostasis cytochromes p450 p450 cyp17a1 spectroelectrochemistry biological inorganic chemistry oxygen reduction reaction toxicological mechanism protein assembly aldo-keto reductase biocatalysis scaffold protein resonance raman active site monomeric cyp3a4 solvent isotope effects lipid movement membrane formation molecular communication molecular switches controlled size membrane scaffold protein membrane biochemistry nanometer scale nadph oxidation cholesterol esters membrane scaffold proteins protein structure prediction structural biology protein structure protein biogenesis

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract Lb010: C5f2-Hexyl-(Cuban-1-Yl-Methyl)-Biguanide (C5F2-Hcb) Overcomes an Immune Excluded Tumor Microenvironment (Tme) and Suppresses Tumor Growth in the Ovarian Dependent Er+Her2- Ssm2Ucd Mammary Carcinoma Allograft Model. Cancer Research (2025)

Zhijun GuoJianxun LeiJoshua McCarraQing CaoMichael J. PryzbillaBrenda KoniarBeverly NorrisRobert J. SchumacherSwaathi JayaramanJohn R. HawseAntonino B. D'AssoroIlia G. DenisovStephen G. SligarKathryn L. SchwertfegerMichael A. FarrarDipak PanigrahyHammock D. BruceElizabeth A. AmbroseGunda I. GeorgGoetz P. MatthewDavid A. Potter

breast oncologycell biologymolecular canceranti-cancer agentsbreast cancertumor microenvironmentcancer biologycell metabolismcancer researchtherapeutic targetscancer growthtumor biologytumor growthepoxy fatty acidpharmacologycancer discoveryoncogenescancer cellsmedicinal researcheets biosynthesis

Cryoradiolysis of Oxygenated Cytochrome P450 17A1 With Lyase Substrates Generates Expected Products. Journal of Inorganic Biochemistry (2024)

Remigio UsaiIlia G. DenisovStephen G. SligarJames R. Kincaid

biochemical engineeringdrug metabolismaldehyde dehydrogenaseredox biologylyase substrates generateschemical biologyenzymesmolecular metabolismalcohol dehydrogenasesmolecular biologybiological chemistrycellular enzymologybiochemical sciencesbiochemistry

Nanodiscs for the Study of Membrane Proteins. Current Opinion in Structural Biology (2024)

Ilia G. DenisovStephen G. Sligar

biological macromoleculesbiophysicsmembrane systemsmembrane proteinsmembrane sciencenanodiscbiomoleculesmembrane biology

Optical Annealing of Peroxo-Ferric Intermediates in Cyp17A1 and Product Formation.. Journal of Inorganic Biochemistry (2024)

Ilia G DenisovYelena V GrinkovaStephen G Sligar

material chemistrychemical engineeringperovskite moduleoptical materialsphotochemistrylead-free perovskitescrystal growthchemistryoptical annealingtransition metal chemistry

Solvent Isotope Effects in the Catalytic Cycle of P450 Cyp17A1: Computational Modeling of the Hydroxylation and Lyase Reactions. Journal of Inorganic Biochemistry (2023)

Ilia G. DenisovStephen G. Sligar

chemical kineticssolvent isotope effectscatalysisstructure-function enzyme kineticsaldehyde dehydrogenasep450 cyp17a1chemical biologybiomolecular engineeringenzymesmolecular metabolismbiocatalysischemical scienceschemical reaction engineeringenzyme catalysisorganic process researchlyase reactionsbiochemical sciencesbiochemistry

Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human Cyp17a1. Biochemistry (2022)

Yilin LiuIlia DenisovMichael GregoryStephen G. SligarJames R. Kincaid

enzyme inhibitionaldo-keto reductasesolvent isotope effectsdrug metabolismaldehyde dehydrogenasesteroid metabolismactive site structurechemical biologyenzymesmolecular metabolismmolecular biologybiological chemistrycell metabolismasparagine 202biochemistrybiosynthesis

Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by Cyp3a4. Biomolecules (2022)

Ilia G. DenisovYelena V. GrinkovaMark A. McLeanTyler CampStephen G. Sligar

md simulationsdrug targetslipid nanodiscspharmacologypharmacokineticsdrug metabolismpharmacotherapymolecular pharmacologytherapeutic targetsapplied pharmacologydrug discoverynew drug candidatespharmaceutical sciencespharmacological researchbiochemistry

Abstract Lb078: Hexyl-(Cuban-1-Yl-Methyl)-Biguanide (Hcb) Inhibits Hormone Therapy Resistant Breast Cancer Cells, in Part by Inhibiting Cyp3A4 Arachidonic Acid Epoxygenase Activity. Cancer Research (2021)

Zhijun GuoJianxun LeiKwon Ho HongBeverly NorrisCraig M. FlorySwaathi JayaramanConnor McDermottElizabeth AmbroseIrina SevrioukovaTom PoulosIlia DenisovStephen SligaRobert J. SchumacherGunda I. GeorgJohn R. HawseMatthew P. GoetzDavid A. Potter

medicinal chemistrypharmaceutical chemistrybiochemistrybreast oncologymolecular canceranti-cancer agentshcb treatmentbreast cancerendocrine-related cancerstherapeutic targetsbioactive compoundstumor biologypharmacological researchenzyme inhibitionpharmacologyepoxygenase activitycancer discoverydrug discoveryoncogenesmedicinal research

Mechanism of the Clinically Relevant E305G Mutation in Human P450 Cyp17a1. Biochemistry (2021)

Yilin LiuYelena GrinkovaMichael C. GregoryIlia G. DenisovJames R. KincaidStephen G. Sligar

endocrine mechanismsdrug metabolismmolecular pharmacologybiological chemistrymetabolismbiochemistryendocrinologycytochrome p450 cyp17a1cytochrome p450sbiochemical sciencessteroid metabolismcell metabolismbiochemical geneticsmolecular metabolismendocrine researchenzyme inhibitionpharmacologyhormonal receptoractive sitemetabolic pathways

Midazolam as a Probe for Drug–Drug Interactions Mediated by Cyp3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation. Biochemistry (2021)

Ilia G. DenisovYelena V. GrinkovaTyler CampMark A. McLeanStephen G. Sligar

drug targetsenzyme inhibitionpharmacologyproductive sitemechanisms of actiondrug metabolismmolecular pharmacologyfirst mdz moleculemembrane surfacedrug discoverypharmacological researchbiochemistry

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Ilia G Denisov

Research Scientist

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Ilia G Denisov is currently serving as a College Of Liberal Arts & Sciences Research Scientist at Uiuc.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Ilia G Denisov

UIUC

Research Scientist

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cryoradiolysis of Oxygenated Cytochrome P450 17A1 With Lyase Substrates Generates Expected Products. Journal of Inorganic Biochemistry (2024)

Remigio UsaiIlia G. DenisovStephen G. SligarJames R. Kincaid

Nanodiscs for the Study of Membrane Proteins. Current Opinion in Structural Biology (2024)

Ilia G. DenisovStephen G. Sligar

biological macromoleculesbiophysicsmembrane systemsmembrane proteinsmembrane sciencenanodiscbiomoleculesmembrane biology

Optical Annealing of Peroxo-Ferric Intermediates in Cyp17A1 and Product Formation.. Journal of Inorganic Biochemistry (2024)

Ilia G DenisovYelena V GrinkovaStephen G Sligar

material chemistrychemical engineeringperovskite moduleoptical materialsphotochemistrylead-free perovskitescrystal growthchemistryoptical annealingtransition metal chemistry

Solvent Isotope Effects in the Catalytic Cycle of P450 Cyp17A1: Computational Modeling of the Hydroxylation and Lyase Reactions. Journal of Inorganic Biochemistry (2023)

Ilia G. DenisovStephen G. Sligar

Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human Cyp17a1. Biochemistry (2022)

Yilin LiuIlia DenisovMichael GregoryStephen G. SligarJames R. Kincaid

Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by Cyp3a4. Biomolecules (2022)

Ilia G. DenisovYelena V. GrinkovaMark A. McLeanTyler CampStephen G. Sligar

Mechanism of the Clinically Relevant E305G Mutation in Human P450 Cyp17a1. Biochemistry (2021)

Yilin LiuYelena GrinkovaMichael C. GregoryIlia G. DenisovJames R. KincaidStephen G. Sligar

Midazolam as a Probe for Drug–Drug Interactions Mediated by Cyp3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation. Biochemistry (2021)

Ilia G. DenisovYelena V. GrinkovaTyler CampMark A. McLeanStephen G. Sligar

drug targetsenzyme inhibitionpharmacologyproductive sitemechanisms of actiondrug metabolismmolecular pharmacologyfirst mdz moleculemembrane surfacedrug discoverypharmacological researchbiochemistry

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5
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10 / page