Faculty

Institution

Unit

Venue

Debabrata Chakravarti

Anna Lapham Professor of Obstetrics and Gynecology Vice Chair for Translational Research Department of Obstetrics and Gynecology

Northwestern University

Affiliations

Feinberg School of Medicine

Department of Obstetrics & Gynecology

Debabrata Chakravarti is currently serving as an Obstetrics & Gynecology Anna Lapham Professor of Obstetrics and Gynecology Vice Chair for Translational Research Department of Obstetrics and Gynecology at Northwestern University.

Honors

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Experiences

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Education

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Debabrata Chakravarti

Northwestern University

Anna Lapham Professor of Obstetrics and Gynecology Vice Chair for Translational Research Department of Obstetrics and Gynecology

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cell biology molecular biology genetics tumor biology gene expression cancer biology oncology cancer research epigenetics endocrinology cell signaling transcription regulation biochemistry cancer genetics molecular regulation molecular cell biology medicinal research reproductive biology reproductive medicine enzyme inhibition molecular and cellular biology cancer cells gene regulation human reproduction cell regulation molecular cancer endocrine oncology gynecologic oncology leukemia oncogenes molecular physiology cancer genomics epigenetic changes signaling pathways rna biology gene function endocrine research cancer growth biological chemistry obstetrics and gynaecology cancer care assisted reproduction reproductive science sterility reproductive physiology epigenomics histone acetylation uterine leiomyomas uterine leiomyoma chromatin remodeling transcriptional repression chromosome biology cellular biology tumor targeting cytogenetics female reproductive system receptor (biochemistry) protein expression colorectal cancer renal function thanatology cancer treatment uterine fibroids chronobiology mammalian physiology multimeric activation complex nuclear receptor repression histone deacetylase nuclear receptor human cellular complex nuclear hormone receptors viral mechanism pcaf acetyltransferase activity androgen-receptor-mediated transcriptional program castration-resistant prostate cancer lncrna hotair

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Bivalent Lysine-Acetylated Small-Molecule Binding Site in Myc. bioRxiv (Cold Spring Harbor Laboratory) (2026)

biophysicsprotein chemistrysmall moleculesmolecular sciencemolecular structurebivalent lysine-acetylated small-moleculemolecular recognitionmolecular modelsmolecular basisprotein science

Impaired Mitochondrial Metabolism is a Critical Cancer Vulnerability for Myc Inhibitors. Science Advances (2025)

pharmacologymetabolic remodelingcancer researchmolecular cancermitochondrial functionmolecular metabolismoncologyoncogenic agentoncogenescancer cellsimpaired mitochondrial metabolismmetabolic pathwayscell metabolismmyc inhibitorstumor biologycritical cancer vulnerabilitycell biology

Uterine Fibroids. Physiological Reviews (2025)

Serdar E BulunPing YinJian-Jun WeiAzna ZuberiTakashi IizukaTakuma SuzukiPriyanka SainiJyoti GoadJ. Brandon ParkerMazhar AdliThomas BoyerDebabrata ChakravartiAleksandar Rajkovic

gynecologyveterinary medicinefemale reproductive systemuterine fibroids

Engineered Uterine Primary Myometrial Cells With High-Mobility Group At-Hook 2 Overexpression Display a Leiomyoma-Like Transcriptional and Epigenomic Phenotype. F&S Science (2024)

Priyanka SainiAustin G. HolmesJian-Jun WeiJ. Brandon ParkerDebabrata Chakravarti

genomicsgenome biologygene expressionepigenomicstranscription regulationtranscription (biology)systems biologygynecologic oncologyepigenetic changesepigenomic phenotypemolecular cell biologymatrix biologygene functionleiomyoma-like transcriptionalmolecular biologycellular differentiationmolecular physiologycell biology

Endometriosis and Adenomyosis: Shared Pathophysiology. Fertility and Sterility (2023)

Serdar E. BulunSule YildizMazhar AdliDebabrata ChakravartiJames Brandon ParkerMagdy MiladLinda YangAngela ChaudhariSusan TsaiJian Jun WeiPing Yin

fertilitygynecology

Inhat Subunit Set/Taf-Iβ Regulates Prc1-Independent H2Ak119 Mono-Ubiquitination via E3 Ligase Mib1 in Colon Cancer. NAR Cancer (2023)

Junyoung ParkJi-Young KimJin Woo ParkJoo Young KangHyein OhJa Young HahmYun-Cheol ChaeDebabrata ChakravartiSang Beom Seo

cancer geneticscell signalingcolon cancercell biologycancer carecolorectal cancercancer biologyleukemiacancer researchcancer immunotherapycancer growthcell regulationtumor biologyenzyme inhibitionpharmacologymolecular biologyoncologyoncogenesmedicinal research

Supplementary Table 1 From Transcription Factor Klf11 Integrates Progesterone Receptor Signaling and Proliferation in Uterine Leiomyoma Cells. (2023)

Ping YinZhihong LinScott ReierstadJu WuHiroshi IshikawaErica E. MarshJoy InnesYouhong ChengKerry PearsonJohn Sayler CoonJ. Julie KimDebabrata ChakravartiSerdar E. Bulun

gene expressionuterine leiomyoma cellsendocrinologygeneticstranscription factorshepatologybiochemistrycell biology

Thu625 Med12 Mutation Activates Tryptophan-Kynurenine-Ahr Pathway to Promote Growth of Uterine Leiomyoma. Journal of the Endocrine Society (2023)

Azna ZuberiYongchao HuangAriel J DottsHelen WeiJohn S Coon VTakashi LizukaOlivia WuOlivia SotosDebabrata ChakravartiYang DaiSerdar Ekrem BulunPing Yin

gene expressionpharmacologyendocrine oncologycancer geneticsendocrinologyuterine leiomyomageneticscancer growthmolecular biologyendocrine researchtryptophan-kynurenine-ahr pathway

A Myc Inhibitor Selectively Alters the Myc and Max Cistromes and Modulates the Epigenomic Landscape to Regulate Target Gene Expression. Science Advances (2022)

Austin G. HolmesJ. Brandon ParkerVinay SagarMihai I. TruicaPritin N. SoniHuiying HanGary E. SchiltzSarki A. AbdulkadirDebabrata Chakravarti

immunologygene expressionpharmacologyepigenomicsmyc inhibitormolecular regulationscience advancetarget gene expressionmolecular biologymedicinal researchepigeneticsepigenomic landscapegene regulation

Epigenomic and Enhancer Dysregulation in Uterine Leiomyomas. Human Reproduction Update (2022)

Oliwia W MlodawskaPriyanka SainiJ Brandon ParkerJian-Jun WeiSerdar E BulunMelissa A SimonDebabrata Chakravarti

epigenomicshuman reproductionreproductive medicineenhancer dysregulationgeneticsreproductive physiologyreproductive sciencereproductive biologyepigeneticsreproductive healthcancer biologygynecologyuterine leiomyomas

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Debabrata Chakravarti

Anna Lapham Professor of Obstetrics and Gynecology Vice Chair for Translational Research Department of Obstetrics and Gynecology

Northwestern University

Affiliations

Feinberg School of Medicine

Department of Obstetrics & Gynecology

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Debabrata Chakravarti

Northwestern University

Anna Lapham Professor of Obstetrics and Gynecology Vice Chair for Translational Research Department of Obstetrics and Gynecology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Bivalent Lysine-Acetylated Small-Molecule Binding Site in Myc. bioRxiv (Cold Spring Harbor Laboratory) (2026)

biophysicsprotein chemistrysmall moleculesmolecular sciencemolecular structurebivalent lysine-acetylated small-moleculemolecular recognitionmolecular modelsmolecular basisprotein science

Impaired Mitochondrial Metabolism is a Critical Cancer Vulnerability for Myc Inhibitors. Science Advances (2025)

Uterine Fibroids. Physiological Reviews (2025)

Serdar E BulunPing YinJian-Jun WeiAzna ZuberiTakashi IizukaTakuma SuzukiPriyanka SainiJyoti GoadJ. Brandon ParkerMazhar AdliThomas BoyerDebabrata ChakravartiAleksandar Rajkovic

gynecologyveterinary medicinefemale reproductive systemuterine fibroids

Engineered Uterine Primary Myometrial Cells With High-Mobility Group At-Hook 2 Overexpression Display a Leiomyoma-Like Transcriptional and Epigenomic Phenotype. F&S Science (2024)

Priyanka SainiAustin G. HolmesJian-Jun WeiJ. Brandon ParkerDebabrata Chakravarti

Endometriosis and Adenomyosis: Shared Pathophysiology. Fertility and Sterility (2023)

Serdar E. BulunSule YildizMazhar AdliDebabrata ChakravartiJames Brandon ParkerMagdy MiladLinda YangAngela ChaudhariSusan TsaiJian Jun WeiPing Yin

fertilitygynecology

Inhat Subunit Set/Taf-Iβ Regulates Prc1-Independent H2Ak119 Mono-Ubiquitination via E3 Ligase Mib1 in Colon Cancer. NAR Cancer (2023)

Junyoung ParkJi-Young KimJin Woo ParkJoo Young KangHyein OhJa Young HahmYun-Cheol ChaeDebabrata ChakravartiSang Beom Seo

Supplementary Table 1 From Transcription Factor Klf11 Integrates Progesterone Receptor Signaling and Proliferation in Uterine Leiomyoma Cells. (2023)

Ping YinZhihong LinScott ReierstadJu WuHiroshi IshikawaErica E. MarshJoy InnesYouhong ChengKerry PearsonJohn Sayler CoonJ. Julie KimDebabrata ChakravartiSerdar E. Bulun

gene expressionuterine leiomyoma cellsendocrinologygeneticstranscription factorshepatologybiochemistrycell biology

Thu625 Med12 Mutation Activates Tryptophan-Kynurenine-Ahr Pathway to Promote Growth of Uterine Leiomyoma. Journal of the Endocrine Society (2023)

Azna ZuberiYongchao HuangAriel J DottsHelen WeiJohn S Coon VTakashi LizukaOlivia WuOlivia SotosDebabrata ChakravartiYang DaiSerdar Ekrem BulunPing Yin

gene expressionpharmacologyendocrine oncologycancer geneticsendocrinologyuterine leiomyomageneticscancer growthmolecular biologyendocrine researchtryptophan-kynurenine-ahr pathway

A Myc Inhibitor Selectively Alters the Myc and Max Cistromes and Modulates the Epigenomic Landscape to Regulate Target Gene Expression. Science Advances (2022)

Austin G. HolmesJ. Brandon ParkerVinay SagarMihai I. TruicaPritin N. SoniHuiying HanGary E. SchiltzSarki A. AbdulkadirDebabrata Chakravarti

immunologygene expressionpharmacologyepigenomicsmyc inhibitormolecular regulationscience advancetarget gene expressionmolecular biologymedicinal researchepigeneticsepigenomic landscapegene regulation

Epigenomic and Enhancer Dysregulation in Uterine Leiomyomas. Human Reproduction Update (2022)

Oliwia W MlodawskaPriyanka SainiJ Brandon ParkerJian-Jun WeiSerdar E BulunMelissa A SimonDebabrata Chakravarti

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