Faculty

Institution

Unit

Venue

David L. Williams

Associate Professor

Rush University

Affiliations

College of Health Sciences

Department Of Clinical Nutrition

Rush Medical College

Department Of Microbial Pathogens And Immunity

David L. Williams is currently serving as a College Of Health Sciences Associate Professor at Rush University.

Honors

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Experiences

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Education

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David L. Williams

Rush University

Associate Professor

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biochemistry schistosomiasis pharmacology molecular biology parasitology enzymes redox biology enzyme inhibition antiparasitic agent drug discovery chemical biology microbiology parasite genomics schistosoma mansoni biochemical sciences oxidative stress medicinal chemistry bioorganic chemistry free radical biology biological chemistry toxins natural product research thioredoxin glutathione reductase neglected tropical diseases pharmacognosy invertebrate pathology infection control medicinal research redox signaling pharmaceutical chemistry genomics helminth infection biotransformation parasite control parasitic diseases drug development enzyme catalysis natural product biosynthesis genome biology clinical microbiology tropical medicine molecular metabolism high-throughput screening helminthology host-parasite relationships structure-function enzyme kinetics host response innate immune system redox regulator biocatalysis experimental toxicology drug targets phytochelatin synthase immunopathology phagocytes lymphatic filariasis emerging infectious diseases disease control reactive nitrogen species gene expression profiling cytogenetics genome analysis adaptive immune system essential parasite enzyme key drug target new drug peroxiredoxin drives schistosoma mansoni thioredoxin-glutathione proteomic analysis cell type-specific markers life-cycle stages schistosoma mansoni organs disulfide redox system implicate peroxiredoxins redox balance mechanisms schistosoma mansoni rely

Notable Scholarly Works

Notable Federal Grants

Collaborators

Targeting Apicomplexan Parasites: Structural and Functional Characterization of Cryptosporidium Thioredoxin Reductase as a Novel Drug Target. Biochemistry (2025)

parasitologyparasitic protozoaapicomplexan parasitesenzymesfunctional characterizationantiparasitic agentnovel drug targetima fungusstructural molecular biologybiochemistrymolecular biologyenzyme inhibitionparasite genomicsparasitic diseases

Unravelling the Anti-Cancer Mechanisms Elicited by Non-Covalent Thioredoxin Reductase Inhibitors for Triple Negative Breast Cancer Therapy. Redox Biology (2025)

tumor biologyanti-cancer agentsanti-cancer mechanismscancer researchcell biologybreast oncologyoncogenespharmacologycancer discoverytherapeutic targetsdrug targetingtumor targetingenzyme inhibitiondrug discoverybreast cancer

Abstract 3132: Examining the Role of the Lung Endothelial Cell Anti-Apoptotic Protein C-Iap2 in Schistosomiasis-Associated Pulmonary Hypertension. Arteriosclerosis Thrombosis and Vascular Biology (2024)

pulmonary vascular diseaseinflammationpulmonary arterial hypertensionpulmonary circulationallergyabstract 3132interstitial lung diseaseimmunologyvascular biologyrespiratory medicineschistosomiasis-associated pulmonary hypertensionlung microbiome

Crystal Structures of Human Histone Deacetylase 8 in Complex With Novel Hydroxamic Acid Inhibitors. Acta Crystallographica Section A Foundations and Advances (2024)

Marta PalermaL. N. M. HardingV. Z. PetukhovaF. GabrieleM. ArdiniM. D'AddarioJ. BogardR. IppolitiD. L. WilliamsP. A. PetukhovF. Angelucci

biophysicschromatinx-ray crystallographycrystallographymolecular structurebiomolecular structureprotein structurestructural molecular biologybiochemistrycrystal structuresprotein x-ray crystallographycrystal formationcrystal growthmolecular biologyenzyme inhibitionstructural biology

Pleiotropic Anti-Cancer Activities of Novel Non-Covalent Thioredoxin Reductase Inhibitors Against Triple Negative Breast Cancer. Free Radical Biology and Medicine (2024)

anti-cancer agentsradiation oncologybioactive compoundsbreast oncologyoncogenespharmacologycancer discoverytherapeutic targetscancer treatmentpleiotropic anti-cancer activitiesenzyme inhibitiondrug discoverybreast cancermedicinal research

Regioselective Synthesis of Potential Non-Quinonoid Prodrugs of Plasmodione: Antiparasitic Properties Against Two Hemoglobin-Feeding Parasites and Drug Metabolism Studies. Molecules (2024)

pharmaceutical chemistrypotential non-quinonoid prodrugschemical synthesisnatural productsdrug developmentmedicinal chemistrypharmacognosyantiparasitic agentbiochemistrypharmacologynatural product biosynthesisdrug metabolism studiesnatural product researchenzyme inhibitionnatural product synthesispharmaceuticsantiparasitic properties

The “Doorstop Pocket” in Thioredoxin Reductases─an Unexpected Druggable Regulator of the Catalytic Machinery. Journal of Medicinal Chemistry (2024)

Matteo ArdiniSammy Y. AboagyeValentina Z. PetukhovaIrida KastratiRodolfo IppolitiGregory R. J. ThatcherPavel A. PetukhovDavid L. WilliamsFrancesco Angelucci

pharmaceutical chemistrymedicinal chemistrycatalytic machinerypharmacologydoorstop pocketmedicinal research

Descriptive Analysis of Transient-State Observations for Thioredoxin/Glutathione Reductase (Sec597Cys) From Schistosoma Mansoni. Biochemistry (2023)

Madison M. SmithTyler B. AltDavid L. WilliamsGraham R. Moran

transient-state observationsmicrobiologyenzymesdescriptive analysisbiochemistry

Non-Covalent Inhibitors of Thioredoxin Glutathione Reductase With Schistosomicidal Activity in Vivo. Nature Communications (2023)

Valentina Z. PetukhovaSammy Y. AboagyeMatteo ArdiniRachel P. LulloFrancesca FataMargaret E. ByrneFederica GabrieleLucy M. MartinLuke N. M. HardingVamshikrishna GoneBikash DangiDaniel D. LantvitDejan NikolicRodolfo IppolitiGrégory EffantinWai Li LingJeremy J. JohnsonGregory R. J. ThatcherFrancesco AngelucciDavid L. WilliamsPavel A. Petukhov

enzymesthioredoxin glutathione reductasebiochemistrypharmacologyschistosomicidal activitynon-covalent inhibitorsenzyme inhibitiondrug discovery

Schistosomiasis-Associated Pulmonary Hypertension Unveils Disrupted Murine Gut–Lung Microbiome and Reduced Endoprotective Caveolin-1/Bmpr2 Expression. Frontiers in Immunology (2023)

Ygor MarinhoElizabeth S. VillarrealSammy Y. AboagyeDavid L. WilliamsJun SunClaudia L. M. SilvaSarah E. LutzSuellen D. Oliveira

veterinary medicineinfection controlmicrobiomeclinical microbiologyschistosomiasisimmunologyrespiratory medicinepublic healthmurine gut-lung microbiomeepidemiology

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David L. Williams

Associate Professor

Rush University

Affiliations

College of Health Sciences

Department Of Clinical Nutrition

Rush Medical College

Department Of Microbial Pathogens And Immunity

David L. Williams is currently serving as a College Of Health Sciences Associate Professor at Rush University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

David L. Williams

Rush University

Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Targeting Apicomplexan Parasites: Structural and Functional Characterization of Cryptosporidium Thioredoxin Reductase as a Novel Drug Target. Biochemistry (2025)

Unravelling the Anti-Cancer Mechanisms Elicited by Non-Covalent Thioredoxin Reductase Inhibitors for Triple Negative Breast Cancer Therapy. Redox Biology (2025)

Crystal Structures of Human Histone Deacetylase 8 in Complex With Novel Hydroxamic Acid Inhibitors. Acta Crystallographica Section A Foundations and Advances (2024)

Marta PalermaL. N. M. HardingV. Z. PetukhovaF. GabrieleM. ArdiniM. D'AddarioJ. BogardR. IppolitiD. L. WilliamsP. A. PetukhovF. Angelucci

Pleiotropic Anti-Cancer Activities of Novel Non-Covalent Thioredoxin Reductase Inhibitors Against Triple Negative Breast Cancer. Free Radical Biology and Medicine (2024)

Regioselective Synthesis of Potential Non-Quinonoid Prodrugs of Plasmodione: Antiparasitic Properties Against Two Hemoglobin-Feeding Parasites and Drug Metabolism Studies. Molecules (2024)

The “Doorstop Pocket” in Thioredoxin Reductases─an Unexpected Druggable Regulator of the Catalytic Machinery. Journal of Medicinal Chemistry (2024)

Matteo ArdiniSammy Y. AboagyeValentina Z. PetukhovaIrida KastratiRodolfo IppolitiGregory R. J. ThatcherPavel A. PetukhovDavid L. WilliamsFrancesco Angelucci

pharmaceutical chemistrymedicinal chemistrycatalytic machinerypharmacologydoorstop pocketmedicinal research

Descriptive Analysis of Transient-State Observations for Thioredoxin/Glutathione Reductase (Sec597Cys) From Schistosoma Mansoni. Biochemistry (2023)

Madison M. SmithTyler B. AltDavid L. WilliamsGraham R. Moran

transient-state observationsmicrobiologyenzymesdescriptive analysisbiochemistry

Non-Covalent Inhibitors of Thioredoxin Glutathione Reductase With Schistosomicidal Activity in Vivo. Nature Communications (2023)

enzymesthioredoxin glutathione reductasebiochemistrypharmacologyschistosomicidal activitynon-covalent inhibitorsenzyme inhibitiondrug discovery

Schistosomiasis-Associated Pulmonary Hypertension Unveils Disrupted Murine Gut–Lung Microbiome and Reduced Endoprotective Caveolin-1/Bmpr2 Expression. Frontiers in Immunology (2023)

Ygor MarinhoElizabeth S. VillarrealSammy Y. AboagyeDavid L. WilliamsJun SunClaudia L. M. SilvaSarah E. LutzSuellen D. Oliveira

veterinary medicineinfection controlmicrobiomeclinical microbiologyschistosomiasisimmunologyrespiratory medicinepublic healthmurine gut-lung microbiomeepidemiology

1
2
3
4
5
9
10 / page