Faculty

Institution

Unit

Venue

David M Kranz

Philip A Sharp Endowed Professor Emeritus Phillip A Sharp Professor of Biochemistry

University of Illinois Urbana-Champaign

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Biochemistry

David M Kranz is currently serving as a College Of Liberal Arts & Sciences Philip A Sharp Endowed Professor Emeritus Phillip A Sharp Professor of Biochemistry at University of Illinois Urbana-Champaign.

Honors

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Experiences

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Education

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David M Kranz

University of Illinois Urbana-Champaign

Philip A Sharp Endowed Professor Emeritus Phillip A Sharp Professor of Biochemistry

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immunology immune responses cell biology cellular immune responses cellular therapy cell research antigen processing receptors immunotherapy immunity (medicine) adaptive immune system peptides cancer cells cancer immunotherapy cell signaling cell transplantation molecular cell biology immunologic mechanisms cancer immunosurveillance molecular biology protein science peptide science therapeutic targets antibody engineering signal transduction immunoediting t cells structural molecular biology biomolecular engineering cellular physiology receptor (biochemistry) molecular immunology t-regulatory cell biological macromolecules molecular cancer toxins immune checkpoint inhibitors biomolecular structure immunochemistry cellular biochemistry lymphocyte development antibody screening microbial toxins protein assembly brain tumor research tumor targeting biomolecular interactions yeast cancer biology histocompatibility synthetic immunology virulence factors molecular recognition cell therapy non-peptide ligand immunogenetics toxinology affinity maturation immune system peptide specificity immunoglobulin e t cell activation tcr affinity t cell viral structural protein laboratory immunology peptide therapeutics yeast surface display antigen recognition escherichia coli yeast display structural basis staphylococcus aureus negative selection thermal stability high affinity protein dynamics car-t therapy system immunology systems biology experimental medicine drug discovery

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract Lb075: Small Molecule Procaspase Activating Compound 1 (Pac-1) Enhances Car-T Immunotherapy for Solid Tumors in Syngeneic Murine Models. Cancer Research (2024)

Diana R. RanoaYifei KangJenny DrnevichGloria RendonChristopher J. FieldsKeith BaileyEdward J. RoyTimothy M. FanDavid M. KranzPaul J. Hergenrother

compound 1cancer immunotherapymolecular cancercellular immune responsescancer cellsimmunomodulationimmune systemcell transplantationradiation oncologyabstract lb075cellular therapyimmunotherapyimmunologyimmune checkpoint inhibitorsimmune responsescancer immunosurveillance

Data From Equilibrium Between Host and Cancer Caused by Effector T Cells Killing Tumor Stroma. (2023)

Bin ZhangYi ZhangNatalie A. BowermanAndrea SchietingerYang-Xin FuDavid M. KranzDonald A. RowleyHans Schreiber

cancer immunotherapytumor growthmhc restrictioncellular immune responsesimmune responsescancer cellsoncogenestumor microenvironmentimmunoeditingcellular therapytumor biologyimmunologyimmunotherapycancer immunosurveillancecell biology

Data From T-Cell Receptors Engineered I De Novo /I for Peptide Specificity Can Mediate Optimal T-Cell Activity Without Self Cross-Reactivity. (2023)

Preeti SharmaDaniel T. HarrisJennifer D. StoneDavid M. Kranz

cancer immunotherapyreceptorstcrαβ gene isolationimmune responsescancer-associated peptidespepmhc compleximmunoeditingpeptidesimmunologycell biologyantigen processingpeptide science

Single Car-T Cell Treatment Controls Disseminated Ovarian Cancer in a Syngeneic Mouse Model. Journal for ImmunoTherapy of Cancer (2023)

Diana Rose E RanoaPreeti SharmaClaire P SchaneAmber N LewisEdward ValdezVenkata V V R MaradaMarlies V HagerWill MontgomerySteven P WolfKarin SchreiberHans SchreiberKeith BaileyTimothy M FanPaul J HergenrotherEdward J RoyDavid M Kranz

cell transplantationovarian cancercancer cellscell biologygynecologic cancersgynecologic oncologytumor growthmolecular cancerimmunoeditingt cellsenhanced tumor growthcellular therapyimmunologyimmunotherapycancer immunosurveillanceimmune checkpoint inhibitorsantigen processingcancer immunotherapycellular immune responses

Supplementary Data From High-Throughput Stability Screening of Neoantigen/Hla Complexes Improves Immunogenicity Predictions. (2023)

Dylan T. BlahaScott D. AndersonDaniel M. YoakumMarlies V. HagerYuanyuan ZhaThomas F. GajewskiDavid M. Kranz

high-throughput stability screeningsupplementary databioinformaticscomputational biologysystem immunologysystems biologyimmunologyantigen processingmolecular diagnosticsbiomedical analysishla typing

Supplementary Figure Legends 1-5 From Equilibrium Between Host and Cancer Caused by Effector T Cells Killing Tumor Stroma. (2023)

Bin ZhangYi ZhangNatalie A. BowermanAndrea SchietingerYang-Xin FuDavid M. KranzDonald A. RowleyHans Schreiber

cancer immunotherapycellular immune responsescancer cellstumor microenvironmentsupplementary figurecellular therapyimmunologyimmunotherapycancer immunosurveillancecell biology

Tcr-Engineered Adoptive Cell Therapy Effectively Treats Intracranial Murine Glioblastoma. Journal for ImmunoTherapy of Cancer (2023)

Maximilian O SchaettlerRupen DesaiAnthony Z WangAlexandra J LivingstoneDale K KobayashiAndrew T CoxonJay A Bowman-KiriginConnor J LiuMao LiDiane E BenderMichael J WhiteDavid M KranzTanner M JohannsGavin P Dunn

cancer immunotherapytumor targetingcancer cellsadoptive cellular therapiesintracranial murine glioblastomaneuro-oncologybrain tumor researchcell transplantationcellular therapyimmunologygliomasimmunotherapycell biologynovel therapiescell therapyt cell receptortherapeutic targets

Engineering Proteins by Combining Deep Mutational Scanning and Yeast Display. Methods in molecular biology (2022)

Preeti SharmaErik ProckoDavid M. Kranz

synthetic biologybiomolecular structureprotein engineeringprotein structuremolecular biologybiomolecular engineeringstructural molecular biologydirected evolutionprotein geneticsmolecular biological methodyeastprotein scienceyeast displaymutagenesis (molecular biology technique)

Engineering T Cell Receptors. U.S. Patent No. 11384133 (2022)

David M Kranz

receptorscellular immune responsesimmune responsescellular therapycell signalingimmunologycell researcht-regulatory cellcell biologyt cell receptors

Mitigation of Sars-Cov-2 Transmission at a Large Public University. Nature Communications (2022)

Diana Rose E. RanoaRobin L. HollandFadi G. AlnajiKelsie J. GreenLeyi WangRichard L. FredricksonTong WangGeorge N. WongJohnny UelmenSergei MaslovZachary J. WeinerAlexei V. TkachenkoHantao ZhangZhiru LiuAhmed IbrahimSanjay J. PatelJohn M. PaulNickolas P. VanceJoseph G. GulickSandeep Puthanveetil SatheesanIsaac J. GalvanAndrew MillerJoseph GrohensTodd J. NelsonMary P. StevensP Mark HennessyRobert C. ParkerEdward SantosCharles BrackettJulie D. SteinmanMelvin R. FennerKirstin DohrerMichael DeLorenzoLaura Wilhelm-BarrBrian R. BrauerCatherine Best-PopescuGary DurackNathan WetterDavid M. KranzJessica BreitbarthCharlie SimpsonJulie A. PrydeRobin N. KalerChris HarrisAllison C. VanceJodi L. SilottoMark JohnsonEnrique Andres ValeraPatricia K. AntonLowa MwilambweStephen P. BryanDeborah S. StoneDanita B. YoungWanda E. WardJohn LantzJohn A. VozenilekRashid BashirJeffrey S. MooreMayank GargJulian C. CooperGillian SnyderMichelle H. LoreDustin L. YocumNeal J. CohenJan E. NovakofskiMelanie J. LootsRandy L. BallardMark BandKayla M. BanksJoseph D. BarnesIuliana BenteaJessica BlackJeremy BuschAbigail ConteMadison ConteMichael CurryJennifer EardleyApril EdwardsTherese EggettJudes FleurimontDelaney FosterBruce W. FoukeNicholas GallagherNicole GastalaScott A. GenungDeclan GlueckBrittani GrayAndrew GretaRobert M. HealyAshley HetrickArianna A. HoltermanNahed IsmailIan JasenofPatrick KellyAaron KielbasaTeresa KieselLorenzo M. KindleRhonda L. LipkingYukari C. ManabeJade ́ Mayes

large public universitysars-cov-2 transmissionsars-cov-2infectious diseasesmedical virologyviral diagnosticsrna extractioncovid-19communicable diseasesdisease surveillancepublic health preparednesspublic healthvirus epidemiologycovid-19 pandemicepidemiology

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David M Kranz

Philip A Sharp Endowed Professor Emeritus Phillip A Sharp Professor of Biochemistry

University of Illinois Urbana-Champaign

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Biochemistry

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

David M Kranz

University of Illinois Urbana-Champaign

Philip A Sharp Endowed Professor Emeritus Phillip A Sharp Professor of Biochemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract Lb075: Small Molecule Procaspase Activating Compound 1 (Pac-1) Enhances Car-T Immunotherapy for Solid Tumors in Syngeneic Murine Models. Cancer Research (2024)

Diana R. RanoaYifei KangJenny DrnevichGloria RendonChristopher J. FieldsKeith BaileyEdward J. RoyTimothy M. FanDavid M. KranzPaul J. Hergenrother

Data From Equilibrium Between Host and Cancer Caused by Effector T Cells Killing Tumor Stroma. (2023)

Bin ZhangYi ZhangNatalie A. BowermanAndrea SchietingerYang-Xin FuDavid M. KranzDonald A. RowleyHans Schreiber

Data From T-Cell Receptors Engineered I De Novo /I for Peptide Specificity Can Mediate Optimal T-Cell Activity Without Self Cross-Reactivity. (2023)

Preeti SharmaDaniel T. HarrisJennifer D. StoneDavid M. Kranz

cancer immunotherapyreceptorstcrαβ gene isolationimmune responsescancer-associated peptidespepmhc compleximmunoeditingpeptidesimmunologycell biologyantigen processingpeptide science

Single Car-T Cell Treatment Controls Disseminated Ovarian Cancer in a Syngeneic Mouse Model. Journal for ImmunoTherapy of Cancer (2023)

Supplementary Data From High-Throughput Stability Screening of Neoantigen/Hla Complexes Improves Immunogenicity Predictions. (2023)

Dylan T. BlahaScott D. AndersonDaniel M. YoakumMarlies V. HagerYuanyuan ZhaThomas F. GajewskiDavid M. Kranz

high-throughput stability screeningsupplementary databioinformaticscomputational biologysystem immunologysystems biologyimmunologyantigen processingmolecular diagnosticsbiomedical analysishla typing

Supplementary Figure Legends 1-5 From Equilibrium Between Host and Cancer Caused by Effector T Cells Killing Tumor Stroma. (2023)

Bin ZhangYi ZhangNatalie A. BowermanAndrea SchietingerYang-Xin FuDavid M. KranzDonald A. RowleyHans Schreiber

cancer immunotherapycellular immune responsescancer cellstumor microenvironmentsupplementary figurecellular therapyimmunologyimmunotherapycancer immunosurveillancecell biology

Tcr-Engineered Adoptive Cell Therapy Effectively Treats Intracranial Murine Glioblastoma. Journal for ImmunoTherapy of Cancer (2023)

Engineering Proteins by Combining Deep Mutational Scanning and Yeast Display. Methods in molecular biology (2022)

Preeti SharmaErik ProckoDavid M. Kranz

Engineering T Cell Receptors. U.S. Patent No. 11384133 (2022)

David M Kranz

receptorscellular immune responsesimmune responsescellular therapycell signalingimmunologycell researcht-regulatory cellcell biologyt cell receptors

Mitigation of Sars-Cov-2 Transmission at a Large Public University. Nature Communications (2022)

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