Faculty

Institution

Unit

Venue

Constanza Garcia Keller

Assistant Professor

Medical College of Wisconsin

Affiliations

Departments of Pharmacology and Toxicology

Graduate School

Neuroscience Research Center

Office of Global Health

Constanza Garcia Keller is currently serving as a Departments Of Pharmacology And Toxicology Assistant Professor at Medical College of Wisconsin.

Honors

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Experiences

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Education

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Constanza Garcia Keller

Medical College of Wisconsin

Assistant Professor

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neuroscience addiction pharmacology addiction biology neurology neuropharmacology addictive behaviors neuropsychopharmacology psychiatry behavioral neuroscience substance use disorders stress (biology) substance use addiction medicine neurotransmission neuroimmunology substance abuse biological psychiatry psychopharmacology molecular neuroscience clinical neuroscience neurochemistry addiction treatment neuroinflammation brain-immune interaction pharmacological research opioid use disorder substance addiction nucleus accumbens nucleus accumbens core pharmacotherapy dopamine brain function neurotransmitters molecular neurobiology tobacco control cannabis use brain mechanisms behavioral addictions relapse prevention experimental pharmacology behavioural pharmacology psychoneuroimmunology acute restraint stress glutamatergic mechanisms cocaine self-administration cell death autophagy molecular psychiatry science advance neurodevelopmental disorders behavioral research harm reduction drug targeting brain science cell autophagy drug treatment biomedical research physiological plasticity biological psychology structural plasticity disease progression neuropsychiatry behavioral plasticity neural science ventral pallidum primary target addiction-like synaptic impairments diet-induced obesity glutamate release sensitized dopamine methamphetamine self-administration astrocyte structure toll‐like receptor 2 microglial cell death nicotine-seeking behavior psychoactive substance use post-traumatic stress disorder psychological trauma extracellular matrix psychology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Characterizing Microglial Morphology: Methodological Advances in Confocal Imaging and Analysis. Cells (2025)

neuroradiologyneuropathologybiomedical imagingneuroinflammationneurosciencecentral nervous systemneuroimmunologybrain-immune interactionmicroglial morphologymolecular neurodegenerationneurologyneuroimaging

Dusp5 Downregulation in Nucleus Accumbens Core Correlates With Synaptic Plasticity and Cue-Induced Cocaine Reinstatement. bioRxiv (Cold Spring Harbor Laboratory) (2025)

dopamineneurobiological mechanismsdusp5 downregulationbiological psychiatryneuropharmacologysynaptic plasticityneurosciencebehavioral neuroscienceneurotransmissionrehabilitationnucleus accumbens coreneural circuitsneuropsychopharmacologyaddiction biology

Understanding Microglia in Mesocorticolimbic Circuits: Implications for the Study of Chronic Stress and Substance Use Disorders. Cells (2025)

psychoneuroimmunologymesocorticolimbic circuitsneuroinflammationsubstance use disorderschronic stressneurosciencebrain-immune interactionneuroimmunologyneurologybiological psychiatrystress (biology)neuropsychopharmacology

Accumbens Nitrergic Interneurons Drive the Cell Type-Specific Synaptic Plasticity Required for Cue-Induced Cocaine Seeking. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Adam R. DentonRachel E. ClarkeLisa M. GreenJayda Carroll-DeatonAnnaka M. WestphalBenjamin M. SiemsenAshley G. BrockElizabeth A. HochbergJacob LavineMakoto TaniguchiJacqueline F. McGintyAlex C.W. SmithConstanza Garcia-KellerJames M. OtisMichael D. Scofield

systems neurosciencecellular neurobiologymolecular neurosciencebrain circuitryneurosciencecentral nervous systemneurodynamicsmolecular neurobiologypharmacologybehavioral neuroscienceaddictive behaviorsneurologycognitive neuroscienceaddiction biology

Structural and Kinetic Characterization of Dusp5 With a DI-Phosphorylated Tripeptide Substrate From the Erk Activation Loop.. Front Chem Biol (2024)

protein phosphorylationbiomolecular engineeringerk activation loopprotein scienceprotein structurebiological chemistrybiochemistrysignal transductionpeptide scienceprotein functionstructural biologykinetic characterizationdi-phosphorylated tripeptide substrate

Δ 9 ‐Tetrahydrocannabinol Self‐Administration Induces Cell Type‐Specific Adaptations in the Nucleus Accumbens Core. Addiction Biology (2023)

Constanza Garcia‐KellerMadeline HohmeisterKailyn SeidlingLauren BeloateVivian ChiomaSade SpencerPeter KalivasDaniela Neuhofer

cell biologyneurosciencepharmacologytype-specific adaptationsaddictionnucleus accumbens coreaddiction biology

Assessing Combined Effects of Varenicline and N ‐Acetylcysteine on Reducing Nicotine Seeking in Rats. Addiction Biology (2022)

Rusty W. NallLauren N. BeloateMichael E. MeyerinkTiffany PenalozaJade DoolittleBrett FroeligerPeter W. KalivasConstanza Garcia‐Keller

substance addictionsubstance abuseneuropharmacologynicotinesubstance use disordersaddiction medicinebehavioral sciencespharmacologyaddiction treatmentaddictionaddictive behaviorsbehavioral addictionssubstance useopioid use disorderaddiction biology

Assessing Combined Effects of Varenicline and N-Acetylcysteine on Reducing Nicotine Seeking in Rats. Addict Biol (2022)

psychopharmacologyneuropharmacologypharmacological researchbehavioural pharmacologynicotineexperimental pharmacologypharmacologyapplied pharmacologyaddictionphysiologymolecular pharmacologytobacco controlpharmacological studiesdrug discoverypharmacotherapycombined effectsneuropsychopharmacologyaddiction biology

Cannabinoid Use is Enhanced by Stress and Changes Conditioned Stress Responses. Neuropsychopharmacology (2022)

Ritchy HodebourgMichael E. MeyerinkAyteria D. CrowCarmela M. ReichelPeter W. KalivasConstanza Garcia-Keller

functional requirementsubstance use disordersanxiety disorderskey sitepsychoneuroendocrinologyaddictive behaviorstranslational psychiatrybehavioral sciencesstress responsespublic healthsubstance usepineal researchuneven developmentshort-term variabilitydepressionaddictioncannabinoid useschizophreniacarceral settinghealth sciences

Impairment of Glutamate Homeostasis in the Nucleus Accumbens Core Underpins Cross-Sensitization to Cocaine Following Chronic Restraint Stress. Frontiers in Physiology (2022)

María P. AvalosAndrea S. GuzmanConstanza Garcia-KellerBethania Mongi-BragatoMaría A. EsparzaDaiana RigoniMarianela A. SanchezGastón D. CalfaFlavia A. BollatiLiliana M. Cancela

substance abusesubstance use disordersneurosciencecentral nervous systemglutamate homeostasisunderpins cross-sensitizationchronic restraint stressaddictionphysiologyaddictive behaviorsmolecular biologysubstance usenucleus accumbensstress (biology)brain functionaddiction biology

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Constanza Garcia Keller

Assistant Professor

Medical College of Wisconsin

Affiliations

Departments of Pharmacology and Toxicology

Graduate School

Neuroscience Research Center

Office of Global Health

Constanza Garcia Keller is currently serving as a Departments Of Pharmacology And Toxicology Assistant Professor at Medical College of Wisconsin.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Constanza Garcia Keller

Medical College of Wisconsin

Assistant Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Characterizing Microglial Morphology: Methodological Advances in Confocal Imaging and Analysis. Cells (2025)

Dusp5 Downregulation in Nucleus Accumbens Core Correlates With Synaptic Plasticity and Cue-Induced Cocaine Reinstatement. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Understanding Microglia in Mesocorticolimbic Circuits: Implications for the Study of Chronic Stress and Substance Use Disorders. Cells (2025)

Accumbens Nitrergic Interneurons Drive the Cell Type-Specific Synaptic Plasticity Required for Cue-Induced Cocaine Seeking. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Structural and Kinetic Characterization of Dusp5 With a DI-Phosphorylated Tripeptide Substrate From the Erk Activation Loop.. Front Chem Biol (2024)

Δ 9 ‐Tetrahydrocannabinol Self‐Administration Induces Cell Type‐Specific Adaptations in the Nucleus Accumbens Core. Addiction Biology (2023)

Constanza Garcia‐KellerMadeline HohmeisterKailyn SeidlingLauren BeloateVivian ChiomaSade SpencerPeter KalivasDaniela Neuhofer

cell biologyneurosciencepharmacologytype-specific adaptationsaddictionnucleus accumbens coreaddiction biology

Assessing Combined Effects of Varenicline and N ‐Acetylcysteine on Reducing Nicotine Seeking in Rats. Addiction Biology (2022)

Rusty W. NallLauren N. BeloateMichael E. MeyerinkTiffany PenalozaJade DoolittleBrett FroeligerPeter W. KalivasConstanza Garcia‐Keller

Assessing Combined Effects of Varenicline and N-Acetylcysteine on Reducing Nicotine Seeking in Rats. Addict Biol (2022)

Cannabinoid Use is Enhanced by Stress and Changes Conditioned Stress Responses. Neuropsychopharmacology (2022)

Ritchy HodebourgMichael E. MeyerinkAyteria D. CrowCarmela M. ReichelPeter W. KalivasConstanza Garcia-Keller

Impairment of Glutamate Homeostasis in the Nucleus Accumbens Core Underpins Cross-Sensitization to Cocaine Following Chronic Restraint Stress. Frontiers in Physiology (2022)

María P. AvalosAndrea S. GuzmanConstanza Garcia-KellerBethania Mongi-BragatoMaría A. EsparzaDaiana RigoniMarianela A. SanchezGastón D. CalfaFlavia A. BollatiLiliana M. Cancela

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