Faculty

Institution

Unit

Venue

Christopher J. Kristich

Professor; Director Center for Infectious Disease Research

Medical College of Wisconsin

Affiliations

Center for Infectious Disease Research

Center for Microbiome Research

Graduate School

Microbiology & Immunology

Christopher J. Kristich is currently serving as a Center For Infectious Disease Research Professor; Director Center for Infectious Disease Research at Medical College of Wisconsin.

Honors

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Experiences

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Education

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Christopher J. Kristich

Medical College of Wisconsin

Professor; Director Center for Infectious Disease Research

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microbiology enterococcus faecalis infectious diseases antimicrobial resistance clinical microbiology bacteriology drug resistance cephalosporin resistance bacteria microbial pathogenesis pathogenic bacteria molecular biology antimicrobial agents gut microbes antibiotic resistance applied microbiology infection control antimicrobial chemotherapy molecular microbiology immunology cell wall digestive diseases medical microbiology pathogens biofilms signal transduction protein science environmental microbiology molecular gastroenterology enzyme inhibition molecular regulation protein phosphorylation gut barrier pasta kinase structural molecular biology gut-organ axis host response digestive tract microbial genetics antimicrobial susceptibility antimicrobial resistance genes mucosal immunology pathogen transmission signaling pathways mammalian gastrointestinal tract biofilm formation reciprocal regulation crors two-component system two-component signaling system mammalian biology free radical biology proteome research clinical proteomics molecular physiology dysbiosis host genetics electron microscopy mutagenesis microbial physiology veterinary microbiology genetic basis novel therapies probiotics host specificity enzyme specificity microbial proteomics receptor tyrosine kinases oral microbiology bacteriocin production augments esp-independent biofilm formation host-genotype-independent counterselectable marker cationic dyes high-resolution visualization microbial glycocalyx enterococcal infection intestinal persistence bacterial genetics

Notable Scholarly Works

Notable Federal Grants

Collaborators

Correction for Nelson Et Al., “Pbp4 Provides Transpeptidase Activity to the Ftsw-Pbpb Peptidoglycan Synthase to Drive Cephalosporin Resistance in Enterococcus Faecalis ”. Antimicrobial Agents and Chemotherapy (2025)

Madison E. NelsonJaime L. LittleChristopher J. Kristich

cephalosporin resistanceftsw-pbpb peptidoglycan synthaseinfectious diseasesenterococcus faecalisantimicrobial resistancedrug resistancetranspeptidase activity

Pasta Kinase Signaling Regulates Peptidoglycan Synthesis in Enterococcus Faecalis by Direct Inhibition of Udp-N-Acetylglucosamine 1-Carboxyvinyl Transferase Activity. mBio (2025)

Carly A. MascariDušanka DjorićChristopher J. Kristich

inhibitory activityenzymesenterococcus faecalisdirect inhibitionmicrobiologypasta kinasemolecular biologysystems biologyenzyme inhibition

Phosphorylation of the Cell Wall Hydrolase Mltg in Response to Cell Wall Stress Modulates Resistance Toward Cephalosporins in Enterococcus Faecalis. Journal of Bacteriology (2025)

clinical microbiologypathogenic bacteriamolecular microbiologymicroorganismswall stress modulatesbiochemistrymicrobiologydrug resistanceantimicrobial resistancecell metabolismgut microbesmicrobial cell factorycell wallvirulence factorsbacteriologyapplied microbiologymicrobial pathogenesis

The Cell Wall Hydrolase Mltg is Essential to Maintain Cell Wall Homeostasis of Enterococcus Faecalis. Journal of Bacteriology (2025)

applied microbiologypathogenic bacteriamicroorganismscell biologydigestive diseasesgut barriermicrobiologybacteriagut microbesfood microbiologymicrobial cell factorymolecular gastroenterologycell wallvirulence factorsbacteriologycell wall homeostasismicrobiomemicrobial pathogenesis

Ccr2-Dependent Cx3Cr1+ Colonic Macrophages Promote Enterococcus Faecalis Dissemination. Infection and Immunity (2024)

Kevin C. JenningsKaitlin E. JohnsonMichael A. HaywardChristopher J. KristichNita H. Salzman

clinical microbiologymicrobial diseaseinfectious diseasespathogen transmissionenterococcus faecalispathogenic bacteriaimmunologymicrobiologypathogensimmune responsesimmunity (medicine)mucosal immunologyinfection controlmicrobial pathogenesis

Pbp4 Provides Transpeptidase Activity to the Ftsw-Pbpb Peptidoglycan Synthase to Drive Cephalosporin Resistance in Enterococcus Faecalis. Antimicrobial Agents and Chemotherapy (2024)

Madison E. NelsonJaime L. LittleChristopher J. Kristich

cephalosporin resistanceantimicrobial agentsftsw-pbpb peptidoglycan synthaseenterococcus faecalisantimicrobial chemotherapyantimicrobial resistancemicrobiologydrug resistancetranspeptidase activity

Reciprocal Regulation of Enterococcal Cephalosporin Resistance by Products of the Autoregulated Yvcj-Glmr-Yvcl Operon Enhances Fitness During Cephalosporin Exposure. PLoS Genetics (2024)

Dušanka DjorićSamantha N. AtkinsonChristopher J. Kristich

enterococcal cephalosporin resistancecephalosporin exposuregeneticsfitness

The Extracellular Segment of Cros is Not Required for Sensing but Fine-Tunes the Magnitude of Cros Signaling to Regulate Cephalosporin Resistance in Enterococcus Faecalis. Journal of Bacteriology (2024)

Sarah B. TimmlerChristopher J. Kristich

cephalosporin resistanceenterococcus faecalismicrobiologybacteriabacteriology

Conformational Changes in the Activation Loop of a Bacterial Pasta Kinase.. Protein Sci (2023)

conformational changesbacterial pasta kinaseprotein phosphorylationprotein sciencebiomolecular structuremolecular microbiologyactivation loopmicrobiologybacteriamolecular cell biologyprokaryotic systemvirulence factorsmolecular biologyprotein structurebacteriologystructural molecular biologystructural biology

Conformational Changes in the Activation Loop of a Bacterial Pasta Kinase. Protein Science (2023)

Matthew S. BlumaKathryn M. SchultzChristopher J. KristichCandice S. Klug

conformational changesprotein scienceactivation loopbiochemistrymicrobiologybacteriamolecular biologystructure-function enzyme kinetics

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Christopher J. Kristich

Professor; Director Center for Infectious Disease Research

Medical College of Wisconsin

Affiliations

Center for Infectious Disease Research

Center for Microbiome Research

Graduate School

Microbiology & Immunology

Christopher J. Kristich is currently serving as a Center For Infectious Disease Research Professor; Director Center for Infectious Disease Research at Medical College of Wisconsin.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Christopher J. Kristich

Medical College of Wisconsin

Professor; Director Center for Infectious Disease Research

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Madison E. NelsonJaime L. LittleChristopher J. Kristich

cephalosporin resistanceftsw-pbpb peptidoglycan synthaseinfectious diseasesenterococcus faecalisantimicrobial resistancedrug resistancetranspeptidase activity

Pasta Kinase Signaling Regulates Peptidoglycan Synthesis in Enterococcus Faecalis by Direct Inhibition of Udp-N-Acetylglucosamine 1-Carboxyvinyl Transferase Activity. mBio (2025)

Carly A. MascariDušanka DjorićChristopher J. Kristich

inhibitory activityenzymesenterococcus faecalisdirect inhibitionmicrobiologypasta kinasemolecular biologysystems biologyenzyme inhibition

Phosphorylation of the Cell Wall Hydrolase Mltg in Response to Cell Wall Stress Modulates Resistance Toward Cephalosporins in Enterococcus Faecalis. Journal of Bacteriology (2025)

The Cell Wall Hydrolase Mltg is Essential to Maintain Cell Wall Homeostasis of Enterococcus Faecalis. Journal of Bacteriology (2025)

Ccr2-Dependent Cx3Cr1+ Colonic Macrophages Promote Enterococcus Faecalis Dissemination. Infection and Immunity (2024)

Kevin C. JenningsKaitlin E. JohnsonMichael A. HaywardChristopher J. KristichNita H. Salzman

Pbp4 Provides Transpeptidase Activity to the Ftsw-Pbpb Peptidoglycan Synthase to Drive Cephalosporin Resistance in Enterococcus Faecalis. Antimicrobial Agents and Chemotherapy (2024)

Madison E. NelsonJaime L. LittleChristopher J. Kristich

cephalosporin resistanceantimicrobial agentsftsw-pbpb peptidoglycan synthaseenterococcus faecalisantimicrobial chemotherapyantimicrobial resistancemicrobiologydrug resistancetranspeptidase activity

Reciprocal Regulation of Enterococcal Cephalosporin Resistance by Products of the Autoregulated Yvcj-Glmr-Yvcl Operon Enhances Fitness During Cephalosporin Exposure. PLoS Genetics (2024)

Dušanka DjorićSamantha N. AtkinsonChristopher J. Kristich

enterococcal cephalosporin resistancecephalosporin exposuregeneticsfitness

Sarah B. TimmlerChristopher J. Kristich

cephalosporin resistanceenterococcus faecalismicrobiologybacteriabacteriology

Conformational Changes in the Activation Loop of a Bacterial Pasta Kinase.. Protein Sci (2023)

Conformational Changes in the Activation Loop of a Bacterial Pasta Kinase. Protein Science (2023)

Matthew S. BlumaKathryn M. SchultzChristopher J. KristichCandice S. Klug

conformational changesprotein scienceactivation loopbiochemistrymicrobiologybacteriamolecular biologystructure-function enzyme kinetics

1
2
3
4
5
6
7
10 / page

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microbial pathogenesis

microbial genetics

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Institution

University of Oklahoma

molecular biology

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Institution

Miami University

virulence

light sensing

Christopher M Waters

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infectious diseases

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Xingmin Sun

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microbial toxin

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endotoxin activity

Michael Federle

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