Faculty

Institution

Unit

Venue

Christopher Burge

Professor

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Christopher Burge is currently serving as a Biology Professor at Massachusetts Institute of Technology.

Honors

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Experiences

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Education

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Christopher Burge

Massachusetts Institute of Technology

Professor

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molecular biology genetics genomics rna biology gene expression genome biology cell biology bioinformatics neuroscience human genetics transcription regulation gene regulation molecular cell biology epigenetics functional genomics mammalian biology protein science membrane biology transcriptomics technology sequence analysis molecular genetics molecular physiology molecular regulation genome analysis splicing variant computational genomics plo biology cancer genetics cellular physiology medicinal research gene function cell regulation cancer biology avian biology protein expression cellular biology epigenomics cancer genomics biomolecular interactions stem cell research target prediction non-coding rna small rna molecular adaptation dna sequencing medical genetics alternative splicing rna-seq data mbnl proteins pre-mrna splicing author correction nucleic acids cardiovascular research structural molecular biology oncogenes genome studies population genomics gene regulatory networks microbial genetics amyotrophic lateral sclerosis protein genetics mutagenesis yeast human genes dna elements mirna expression functional map human rna-binding proteins large-scale binding regulatory elements systematic identification quantitative visualization heat shock splice sites plant science cell death transcription (biology) systems biology rna processing mrna localization

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Interpretable Model of Pre-Mrna Splicing for Animal and Plant Genes. Science Advances (2024)

Kayla McCueChristopher B. Burge

geneticsfunctional genomicsavian biologybioinformaticsgene expressiongenomicsrna biologyplant geneticsmolecular biologyplant genesinterpretable modelpre-mrna splicinganimal biotechnologybiological engineering

Improved Modeling of Rna-Binding Protein Motifs in an Interpretable Neural Model of Rna Splicing. Genome biology (2024)

Kavi GuptaChenxi YangKayla McCueOsbert BastaniPhillip A. SharpChristopher B. BurgeArmando Solar-Lezama

geneticsbioinformaticsgenomicsrna biologyneurosciencerna-binding protein motifsrna splicingmolecular biologygenome biologyprotein modelinginterpretable neural modelcomputational neuroscience

KATMAP: Inferring Splicing Factor Activity and Regulatory Targets From Knockdown Data. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Michael P. McGurkDavid C. McWattersChristopher B. Burge

pharmacologyfunctional genomicsbioinformaticsgene expressionmachine learningregulatory targetsmolecular physiologytranslational bioinformaticscomputational genomicsmolecular biologygenome biologyprotein bioinformaticsimmunologyepigenomicsepigeneticstranscriptomics technologyprotein science

Molecular and Cellular Context Influences Scn8A Variant Function. JCI Insight (2024)

Carlos G VanoyeTatiana V AbramovaJean-Marc DeKeyserNora F GhabraMadeleine J OudinChristopher B BurgeIngo HelbigChristopher H ThompsonAlfred L George

geneticsgenetic variationmolecular adaptationmembrane biologymolecular cell biologymolecular geneticsgene expressionmolecular diversitymolecular physiologymolecular biologycell biologymolecular and cellular biologyvariant function

Quantifying Negative Selection in Human 3ʹ Utrs Uncovers Constrained Targets of Rna-Binding Proteins. Nature Communications (2024)

Scott D FindlayLindsay RomoChristopher B Burge

geneticshuman geneticsnegative selectionrna biologyrna-binding proteinsmolecular biologyimmunology

Regulatory Features Aid Interpretation of 3′Utr Variants. The American Journal of Human Genetics (2024)

Lindsay RomoScott D. FindlayChristopher B. Burge

geneticshuman geneticspopulation geneticsgene expressiongenomicsmedical geneticsvariant interpretationgenetic variationregulatory features

Sequence Determinants of Intron-Mediated Enhancement Learned From Thousands of Random Introns. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Emma J. K. KowalYuta SakaiMichael P. McGurkZoe J. PasetskyChristopher B. Burge

random intronsmachine learningneuroscienceintron-mediated enhancementsequence determinants

Understanding Species-Specific and Conserved Rna-Protein Interactions in Vivo and in Vitro. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Sarah E. HarrisMaria S. AlexisGilbert GiriFrancisco F. CavazosJernej MurnMaria M. AlemanChristopher B. BurgeDaniel Dominguez

geneticsgenomicsconservation biologyrna biologygene regulationhost specificitymolecular biologybiomolecular interactionsgenome biologyevolutionary biologybiological conservationrna-protein interactions

Understanding Species-Specific and Conserved Rna-Protein Interactions in Vivo and in Vitro. Nature Communications (2024)

Sarah E HarrisMaria S AlexisGilbert GiriFrancisco F CavazosYue HuJernej MurnMaria M AlemanChristopher B BurgeDaniel Dominguez

molecular biologybiomolecular interactionsrna-protein interactions

Widespread Naturally Variable Human Exons Aid Genetic Interpretation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Hannah JacobsBram L. GorissenJeremy GuezMasahiro KanaiHilary K. FinucaneKonrad J. KarczewskiChristopher B. Burge

geneticshuman geneticsgene expressiongenomicsgenetic mechanismsgenomic mechanismsmolecular biologygenetic epidemiologygenetic interpretationgenetic variationvariable human exons

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Christopher Burge

Professor

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Christopher Burge is currently serving as a Biology Professor at Massachusetts Institute of Technology.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Christopher Burge

Massachusetts Institute of Technology

Professor

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Interpretable Model of Pre-Mrna Splicing for Animal and Plant Genes. Science Advances (2024)

Kayla McCueChristopher B. Burge

Improved Modeling of Rna-Binding Protein Motifs in an Interpretable Neural Model of Rna Splicing. Genome biology (2024)

Kavi GuptaChenxi YangKayla McCueOsbert BastaniPhillip A. SharpChristopher B. BurgeArmando Solar-Lezama

geneticsbioinformaticsgenomicsrna biologyneurosciencerna-binding protein motifsrna splicingmolecular biologygenome biologyprotein modelinginterpretable neural modelcomputational neuroscience

KATMAP: Inferring Splicing Factor Activity and Regulatory Targets From Knockdown Data. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Michael P. McGurkDavid C. McWattersChristopher B. Burge

Molecular and Cellular Context Influences Scn8A Variant Function. JCI Insight (2024)

Carlos G VanoyeTatiana V AbramovaJean-Marc DeKeyserNora F GhabraMadeleine J OudinChristopher B BurgeIngo HelbigChristopher H ThompsonAlfred L George

Quantifying Negative Selection in Human 3ʹ Utrs Uncovers Constrained Targets of Rna-Binding Proteins. Nature Communications (2024)

Scott D FindlayLindsay RomoChristopher B Burge

geneticshuman geneticsnegative selectionrna biologyrna-binding proteinsmolecular biologyimmunology

Regulatory Features Aid Interpretation of 3′Utr Variants. The American Journal of Human Genetics (2024)

Lindsay RomoScott D. FindlayChristopher B. Burge

geneticshuman geneticspopulation geneticsgene expressiongenomicsmedical geneticsvariant interpretationgenetic variationregulatory features

Sequence Determinants of Intron-Mediated Enhancement Learned From Thousands of Random Introns. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Emma J. K. KowalYuta SakaiMichael P. McGurkZoe J. PasetskyChristopher B. Burge

random intronsmachine learningneuroscienceintron-mediated enhancementsequence determinants

Understanding Species-Specific and Conserved Rna-Protein Interactions in Vivo and in Vitro. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Sarah E. HarrisMaria S. AlexisGilbert GiriFrancisco F. CavazosJernej MurnMaria M. AlemanChristopher B. BurgeDaniel Dominguez

Understanding Species-Specific and Conserved Rna-Protein Interactions in Vivo and in Vitro. Nature Communications (2024)

Sarah E HarrisMaria S AlexisGilbert GiriFrancisco F CavazosYue HuJernej MurnMaria M AlemanChristopher B BurgeDaniel Dominguez

molecular biologybiomolecular interactionsrna-protein interactions

Widespread Naturally Variable Human Exons Aid Genetic Interpretation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Hannah JacobsBram L. GorissenJeremy GuezMasahiro KanaiHilary K. FinucaneKonrad J. KarczewskiChristopher B. Burge

geneticshuman geneticsgene expressiongenomicsgenetic mechanismsgenomic mechanismsmolecular biologygenetic epidemiologygenetic interpretationgenetic variationvariable human exons

1
2
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5
16
10 / page

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