Faculty

Institution

Unit

Venue

Charles Williams

Assistant Professor

Michigan State University

Affiliations

College of Human Medicine

Department of Medicine

Charles Williams is currently serving as a College Of Human Medicine Assistant Professor at Michigan State University.

Honors

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Experiences

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Education

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Charles Williams

Michigan State University

Assistant Professor

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pharmacology molecular biology developmental biology genetics medicinal research cell signaling vascular biology cardiology enzyme inhibition gene expression drug discovery cancer biology signal transduction small molecules stem cell research protein science signaling pathways tumor targeting disease gene identification cancer treatment stem cells developmental neurobiology circulatory physiology brain tumor research angiogenesis embryonic development molecular regulation cell regulation cardiomyopathy abdominal aortic aneurysms molecular science experimental medicine reproductive medicine applied physiology plo biology biomedical imaging biomedical informatics molecular diagnostics medical image computing polymer engineering biomaterials design induced pluripotent stem cells biological targets drug development rational drug design experimental pathology gene regulation high-throughput screening cohort studies genome-wide association studies pediatric heart disease structural heart disease pharmaceutical nanotechnology therapeutic nanomaterials nanobiotechnology medical technology experimental analysis photobiology computer-aided diagnosis biomedical data integration disease classification matrigel mattress venous cell fate pharmacological target multi-step usage vivo models acidic extracellular microenvironment novel prosurvival pathway phenotypic plunge myometrial calcium-mobilization uterine contractility uk biobank cohort impaired reorganization plga nanoparticle delivery bioelectrical impedance parietal mesothelia hedgehog signaling developmental cell cell biology warburg effect molecular physiology

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Novel Group of Ogremorphin Inhibitors Targeting G Protein-Coupled Sensor Gpr68 Rescue Lipopolysaccharide or Acidosis-Induced Lung Endothelial Dysfunction. (2024)

P. KarkiY. KeC. WilliamsC. HongK.G. BirukovA. Birukova

pulmonary pharmacologyvascular biologyogremorphin inhibitorsmedicinal researchnovel therapiesbiomarker targetendothelial dysfunctionbiomedical engineeringbioactive compoundspharmacologytherapeutic targetsg protein-coupled receptorbiomarkersbiomolecular engineering

Gpr68-Atf4 Signaling is a Novel Prosurvival Pathway in Glioblastoma Activated by Acidic Extracellular Microenvironment. Experimental Hematology and Oncology (2024)

Charles H. WilliamsLeif R. NeitzelJessica CornellSamantha ReaIan MillsMaya S. SilverJovanni D. AhmadKonstantin G. BirukovAnna BirukovaHenry BremBetty TylerEli E. BarCharles C. Hong

experimental pathologyimmunologyacidic extracellular microenvironmentvascular biologytumor biologyhematologycancer researchnovel prosurvival pathwaycancer treatmentmedicinal researchsignaling pathwayscancer biologyneurologytumor targetingbrain tumor researchmedicineexperimental medicineenzyme inhibitiononcologyneuro-oncology

Gpr68 Mediates Lung Endothelial Dysfunction Caused by Bacterial Inflammation and Tissue Acidification. Cells (2024)

Pratap KarkiYunbo KeChenou ZhangKamoltip PromnaresYue LiCharles H. WilliamsCharles C. HongKonstantin G. BirukovAnna A. Birukova

cell deathpulmonary vascular diseasetissue oxygenationtissue acidificationclinical microbiologyvascular biologyinfectious respiratory diseasebacterial inflammationcell signalingmolecular biologygene expressioninflammatory diseasesrespiratory medicinemicrobiologyendothelial dysfunctionsystems biologymicrobial pathogenesisinflammationimmune responsesfree radical biology

Inhibition of Gpr68 Kills Glioblastoma in Zebrafish Xenograft Models. BMC Research Notes (2024)

Leif R. NeitzelDaniela T. FullerCharles H. WilliamsCharles C. Hong

gliomastumor suppressorsmolecular biologyzebrafish xenograft models

Proton Sensing Gpcr’s: The Missing Link to Warburg’s Oncogenic Legacy?. Journal of Cancer Biology (2024)

Jessica CornellSamantha ReaLeif R NeitzelCharles H. WilliamsCharles C. Hong

oncogenescancer researchmolecular biologyoncogenic legacyoncologycancer biology

Abstract 18695: C5orf51/Rimoc1 - a Novel Regulator of Cardiogenesis. Circulation (2023)

Xueyang ZhangAlay GandhiGayatri RatakondaCharles H WilliamsLingfei SunFENG LIChristopher W WardCharles C HongMark T GladwinVijay K YechoorRuya Liu

physiologycardiologynovel regulator

Abstract 1938: Surveying Cancer Cell Type Susceptibility to Ferroptotic Cell Death via Gpr68 Inhibition. Journal of Biological Chemistry (2023)

Sona KocinskyLeif NeitzelCharles WilliamsCharles Hong

ferroptotic cell deathcell deathcell biologycancer researchoncologycancer biology

Abstract 443: Therapeutic Targeting of Gpr68 Activated by Acidic Extracellular Microenvironment Induces Ferroptosis in Glioblastoma Cells. Cancer Research (2023)

Charles H. WilliamsLeif R. NeitzelJessica CornellSamantha ReaIan MillsMaya Silver-IsenstadtJovanni D. AhmadHenry BremBetty TylerEli E. BarCharles C. Hong

anti-cancer agentstherapeutic targetingneurosciencepharmacologytherapeutic targetsglioblastoma cellstumor biologycancer researchcancer treatmentmedicinal researchcellular therapycancer managementcancer carecancer biologyneurologytumor targetingbrain tumor researchenzyme inhibitiononcologyneuro-oncology

Abstract 444: Inhibition of Gpr68 Signaling Activated Downstream of the Warburg Effect Induces Cell Death and Enhances Radiosensitivity in Diverse Cancer Cell Types. Cancer Research (2023)

Leif R. NeitzelHan G. LeeHem ShuklaJaved MahmoodCharles H. WilliamsCharles C. Hong

cell deathpharmacologytumor biologycell signalingcancer researchcancer treatmentcancer cellsreceptorshealth sciencesradiation oncologymedicinal researchcell regulationcancer carecancer managementcancer biologyactivated downstreamcatalyst activationenzyme inhibitiononcology

Impaired Reorganization of Centrosome Structure Underlies Human Infantile Dilated Cardiomyopathy. Circulation (2023)

Young Wook ChunMatthew MiyamotoCharles H. WilliamsLeif R. NeitzelMaya Silver-IsenstadtAdrian G. CadarDaniela T. FullerDaniel C. FongHanhan LiuRobert LeaseSungseek KimMikako KatagiriMatthew D. DurbinKuo-Chen WangTromondae K. FeasterCalvin C. ShengM. Diana NeelyUrmila SreenivasanMarcia Cortes-GutierrezAloke V. FinnRachel SchotGrazia M.S. ManciniSeth A. AmentKevin C. EssAaron B. BowmanZhe HanDavid P. BichellYan Ru SuCharles C. Hong

pediatricsvascular biologycardiologycirculatory physiologypediatric heart diseaseembryonic developmentanatomyneurosciencedevelopmental biologystructural heart diseaseimpaired reorganizationdevelopmental neurobiologyapplied physiologystructural biologycardiomyopathy

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Charles Williams

Assistant Professor

Michigan State University

Affiliations

College of Human Medicine

Department of Medicine

Charles Williams is currently serving as a College Of Human Medicine Assistant Professor at Michigan State University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Charles Williams

Michigan State University

Assistant Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Novel Group of Ogremorphin Inhibitors Targeting G Protein-Coupled Sensor Gpr68 Rescue Lipopolysaccharide or Acidosis-Induced Lung Endothelial Dysfunction. (2024)

P. KarkiY. KeC. WilliamsC. HongK.G. BirukovA. Birukova

Gpr68-Atf4 Signaling is a Novel Prosurvival Pathway in Glioblastoma Activated by Acidic Extracellular Microenvironment. Experimental Hematology and Oncology (2024)

Charles H. WilliamsLeif R. NeitzelJessica CornellSamantha ReaIan MillsMaya S. SilverJovanni D. AhmadKonstantin G. BirukovAnna BirukovaHenry BremBetty TylerEli E. BarCharles C. Hong

Gpr68 Mediates Lung Endothelial Dysfunction Caused by Bacterial Inflammation and Tissue Acidification. Cells (2024)

Pratap KarkiYunbo KeChenou ZhangKamoltip PromnaresYue LiCharles H. WilliamsCharles C. HongKonstantin G. BirukovAnna A. Birukova

Inhibition of Gpr68 Kills Glioblastoma in Zebrafish Xenograft Models. BMC Research Notes (2024)

Leif R. NeitzelDaniela T. FullerCharles H. WilliamsCharles C. Hong

gliomastumor suppressorsmolecular biologyzebrafish xenograft models

Proton Sensing Gpcr’s: The Missing Link to Warburg’s Oncogenic Legacy?. Journal of Cancer Biology (2024)

Jessica CornellSamantha ReaLeif R NeitzelCharles H. WilliamsCharles C. Hong

oncogenescancer researchmolecular biologyoncogenic legacyoncologycancer biology

Abstract 18695: C5orf51/Rimoc1 - a Novel Regulator of Cardiogenesis. Circulation (2023)

Xueyang ZhangAlay GandhiGayatri RatakondaCharles H WilliamsLingfei SunFENG LIChristopher W WardCharles C HongMark T GladwinVijay K YechoorRuya Liu

physiologycardiologynovel regulator

Abstract 1938: Surveying Cancer Cell Type Susceptibility to Ferroptotic Cell Death via Gpr68 Inhibition. Journal of Biological Chemistry (2023)

Sona KocinskyLeif NeitzelCharles WilliamsCharles Hong

ferroptotic cell deathcell deathcell biologycancer researchoncologycancer biology

Abstract 443: Therapeutic Targeting of Gpr68 Activated by Acidic Extracellular Microenvironment Induces Ferroptosis in Glioblastoma Cells. Cancer Research (2023)

Charles H. WilliamsLeif R. NeitzelJessica CornellSamantha ReaIan MillsMaya Silver-IsenstadtJovanni D. AhmadHenry BremBetty TylerEli E. BarCharles C. Hong

Abstract 444: Inhibition of Gpr68 Signaling Activated Downstream of the Warburg Effect Induces Cell Death and Enhances Radiosensitivity in Diverse Cancer Cell Types. Cancer Research (2023)

Leif R. NeitzelHan G. LeeHem ShuklaJaved MahmoodCharles H. WilliamsCharles C. Hong

Impaired Reorganization of Centrosome Structure Underlies Human Infantile Dilated Cardiomyopathy. Circulation (2023)

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5
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