Faculty

Institution

Unit

Venue

Chang Cui

Assistant Professor of Biochemistry

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Chang Cui is currently serving as a College Of Liberal Arts & Sciences Assistant Professor of Biochemistry at Uiuc.

Honors

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Experiences

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Education

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Chang Cui

UIUC

Assistant Professor of Biochemistry

You can click a keyword to filter the displayed items

biochemistry enzymes molecular biology chemistry transition metal chemistry protein structure structural biology biological chemistry structural molecular biology redox biology enzyme inhibition enzyme catalysis chemical biology structural chemistry coordination chemistry biomolecular structure nucleic acids structure-function enzyme kinetics nucleic acid chemistry physics magnetism inorganic chemistry physical chemistry biochemical sciences magnetic resonance molecular structure molecular metabolism protein science chemical sciences molecule-based magnet metalloproteins dna replication coordination complex ferromagnetism magnetic materials redox chemistry aldo-keto reductase heme degradation biocatalysis biological inorganic chemistry long distance subunit interface molecular science molecular complexes rna biology reactive oxygen species heme transport oxygen reduction reaction bioelectrochemistry molecule-based materials cluster chemistry inorganic compounds coordination polymers inorganic synthesis peptide synthesis protein modeling antimicrobial resistance genes antibiotic resistance antimicrobial chemotherapy physicochemical analysis protein chemistry spectra-structure correlation high anisotropy barrier relaxation barrier single co human rnrs unnatural tyrosine analogs conserved tyrosine oxidase activity designed oxidase catalytic rate terminal oxidases hysteresis loop coordination environment fe3+ ions colinear pcet bioorganic chemistry ribonucleotide reductase

Notable Scholarly Works

Notable Federal Grants

Collaborators

Unexpected Effect of an Axial Ligand Mutation in the Type 1 Copper Center in Small Laccase: Structure-Based Analyses and Engineering to Increase Reduction Potential and Activity. Chemical Science (2025)

Jing-Xiang WangAvery C. VilbertLucas H. WilliamsEvan N. MirtsChang CuiYi Lu

biophysical chemistryaxial methioninebioactive metalchemical biologybiomolecular engineeringbiological inorganic chemistrytype 1chemical sciencessmall laccasechemical structuretransition metal chemistrybiochemistry

2.6-Å Resolution Cryo-Em Structure of a Class Ia Ribonucleotide Reductase Trapped With Mechanism-Based Inhibitor N 3 Cdp. Proceedings of the National Academy of Sciences (2024)

Dana E. WestmorelandPatricia R. FelicianoGyunghoon KangChang CuiAlbert KimJoAnne StubbeDaniel G. NoceraCatherine L. Drennan

class ia rnrsbiophysical chemistrymolecular biophysicsenzyme inhibitionaldo-keto reductasenucleic acid chemistrystructure-function enzyme kineticsprotein structurebiomolecular structureenzymesmolecular biologybiological chemistrystructural molecular biologycryogenic electron microscopystructural biologylong distanceprotein sciencebiochemistry

Increasing Reduction Potentials of Type 1 Copper Center and Catalytic Efficiency of Small Laccase From Streptomyces Coelicolor Through Secondary Coordination Sphere Mutations. Angewandte Chemie International Edition (2023)

Jing‐Xiang WangAvery C. VilbertChang CuiEvan N. MirtsLucas H. WilliamsWantae KimY. Jessie ZhangYi Lu

metalloproteinschemical biologyenzymesbiological inorganic chemistrymolecular biologybiological chemistryenzyme catalysissmall laccasetype 1transition metal chemistrybiochemical sciencesreduction potentialsbiochemistry

Radical Transport Facilitated by a Proton Transfer Network at the Subunit Interface of Ribonucleotide Reductase. Journal of the American Chemical Society (2023)

Chang CuiDavid Y. SongCatherine L. DrennanJoAnne StubbeDaniel G. Nocera

aldo-keto reductaseradical transport facilitatedstructure-function enzyme kineticsprotein structurebiomolecular structureenzymesproton transfer networkmolecular biologystructural molecular biologystructural biologysubunit interfacebiochemistry

Ribonucleotide Reductase, a Novel Drug Target for Gonorrhea. DSpace@MIT (Massachusetts Institute of Technology) (2022)

Jana NarasimhanSuzanne LetinskiStephen P JungAleksey GerasyutoJiashi WangMichael ArnoldGuangming ChenJean HedrickMelissa DumbleKanchana RavichandranTalya LevitzChang CuiCatherine L DrennanJoAnne StubbeGary KarpArthur Branstrom

antimicrobial agentsantimicrobial resistance genesantimicrobial resistanceenzyme inhibitionantibiotic resistancenovel drug targetclinical microbiologytherapeutic targetsdrug resistanceantibioticsdrug discoveryng mapinfectious diseasesribonucleotide reductasemicrobiologyantimicrobial chemotherapy

19 F Electron-Nuclear Double Resonance Reveals Interaction Between Redox-Active Tyrosines Across the α/β Interface of E. Coli Ribonucleotide Reductase. Journal of the American Chemical Society (2022)

Andreas MeyerAnnemarie KehlChang CuiFehmke A. K. ReichardtFabian HeckerLisa-Marie FunkManas K. GhoshKuan-Ting PanHenning UrlaubKai TittmannJoAnne StubbeMarina Bennati

colinear pcetα/β interfacenucleic acid chemistrystructure-function enzyme kineticsstructural biologyprotein structureredox biologyredox chemistryenzymesmolecular biologystructural molecular biologyenzyme catalysisdna replicationbiochemistrynucleic acids

Author Response: Ribonucleotide Reductase, a Novel Drug Target for Gonorrhea. (2021)

author responseenzyme inhibitionpharmacologydrug resistancedrug discoverymicrobiologynucleic acids

Gated Proton Release During Radical Transfer at the Subunit Interface of Ribonucleotide Reductase. Journal of the American Chemical Society (2020)

Chang CuiBrandon L. GreeneGyunghoon KangCatherine L. DrennanJoAnne StubbeDaniel G. Nocera

biophysical chemistryproton releasestructure-function enzyme kineticsprotein structureredox biologyredox chemistryenzymesmolecular biologybiological chemistrystructural molecular biologyescherichia colisubunit interfacebiochemistry

Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets. Annual Review of Biochemistry (2020)

Brandon L. GreeneGyunghoon KangChang CuiMarina BennatiDaniel G. NoceraCatherine L. DrennanJoAnne Stubbe

enzyme inhibitionrna biologynucleic acid chemistryprotein structurehuman rnrsbiomolecular structureenzymesdna replicationmolecular metabolismmolecular biologybiological chemistrystructural molecular biologydrug discoverydna repairstructural biologylong distancebiochemistrynucleic acids

Structural Basis for a Quadratic Relationship Between Electronic Absorption and Electronic Paramagnetic Resonance Parameters of Type 1 Copper Proteins. Inorganic Chemistry (2020)

Sheng-Song YuJun-Jie LiChang CuiShiliang TianJie-Jie ChenHan-Qing YuChangjun HouMark J. NilgesYi Lu

metalloproteinsbiophysical chemistrybiophysicsphysicochemical analysismagnetic resonanceprotein chemistryphysical chemistryprotein structuremolecular structurebiomolecular structuretype 1quadratic relationshipchemistrystructural biologyprotein sciencestructural basisspectra-structure correlation

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Chang Cui

Assistant Professor of Biochemistry

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Chang Cui is currently serving as a College Of Liberal Arts & Sciences Assistant Professor of Biochemistry at Uiuc.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Chang Cui

UIUC

Assistant Professor of Biochemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Jing-Xiang WangAvery C. VilbertLucas H. WilliamsEvan N. MirtsChang CuiYi Lu

2.6-Å Resolution Cryo-Em Structure of a Class Ia Ribonucleotide Reductase Trapped With Mechanism-Based Inhibitor N 3 Cdp. Proceedings of the National Academy of Sciences (2024)

Dana E. WestmorelandPatricia R. FelicianoGyunghoon KangChang CuiAlbert KimJoAnne StubbeDaniel G. NoceraCatherine L. Drennan

Jing‐Xiang WangAvery C. VilbertChang CuiEvan N. MirtsLucas H. WilliamsWantae KimY. Jessie ZhangYi Lu

Radical Transport Facilitated by a Proton Transfer Network at the Subunit Interface of Ribonucleotide Reductase. Journal of the American Chemical Society (2023)

Chang CuiDavid Y. SongCatherine L. DrennanJoAnne StubbeDaniel G. Nocera

Ribonucleotide Reductase, a Novel Drug Target for Gonorrhea. DSpace@MIT (Massachusetts Institute of Technology) (2022)

Andreas MeyerAnnemarie KehlChang CuiFehmke A. K. ReichardtFabian HeckerLisa-Marie FunkManas K. GhoshKuan-Ting PanHenning UrlaubKai TittmannJoAnne StubbeMarina Bennati

Author Response: Ribonucleotide Reductase, a Novel Drug Target for Gonorrhea. (2021)

author responseenzyme inhibitionpharmacologydrug resistancedrug discoverymicrobiologynucleic acids

Gated Proton Release During Radical Transfer at the Subunit Interface of Ribonucleotide Reductase. Journal of the American Chemical Society (2020)

Chang CuiBrandon L. GreeneGyunghoon KangCatherine L. DrennanJoAnne StubbeDaniel G. Nocera

Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets. Annual Review of Biochemistry (2020)

Brandon L. GreeneGyunghoon KangChang CuiMarina BennatiDaniel G. NoceraCatherine L. DrennanJoAnne Stubbe

Structural Basis for a Quadratic Relationship Between Electronic Absorption and Electronic Paramagnetic Resonance Parameters of Type 1 Copper Proteins. Inorganic Chemistry (2020)

Sheng-Song YuJun-Jie LiChang CuiShiliang TianJie-Jie ChenHan-Qing YuChangjun HouMark J. NilgesYi Lu

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