Faculty

Institution

Unit

Venue

Chang Cui

Assistant Professor of Biochemistry

University of Illinois Urbana-Champaign

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Biochemistry

Chang Cui is currently serving as a College Of Liberal Arts & Sciences Assistant Professor of Biochemistry at University of Illinois Urbana-Champaign.

Honors

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Experiences

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Education

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Chang Cui

University of Illinois Urbana-Champaign

Assistant Professor of Biochemistry

You can click a keyword to filter the displayed items

biochemistry enzymes molecular biology chemistry transition metal chemistry protein structure structural biology biological chemistry structural molecular biology redox biology enzyme inhibition enzyme catalysis chemical biology structural chemistry coordination chemistry biomolecular structure nucleic acids structure-function enzyme kinetics nucleic acid chemistry physics magnetism inorganic chemistry physical chemistry biochemical sciences magnetic resonance molecular structure molecular metabolism protein science chemical sciences molecule-based magnet metalloproteins dna replication coordination complex ferromagnetism magnetic materials redox chemistry aldo-keto reductase heme degradation biocatalysis biological inorganic chemistry long distance subunit interface molecular science molecular complexes rna biology reactive oxygen species heme transport oxygen reduction reaction bioelectrochemistry molecule-based materials cluster chemistry inorganic compounds coordination polymers inorganic synthesis peptide synthesis protein modeling antimicrobial resistance genes antibiotic resistance antimicrobial chemotherapy physicochemical analysis protein chemistry spectra-structure correlation high anisotropy barrier relaxation barrier single co human rnrs unnatural tyrosine analogs conserved tyrosine oxidase activity designed oxidase catalytic rate terminal oxidases hysteresis loop coordination environment fe3+ ions colinear pcet bioorganic chemistry ribonucleotide reductase

Notable Scholarly Works

Notable Federal Grants

Collaborators

Unexpected Effect of an Axial Ligand Mutation in the Type 1 Copper Center in Small Laccase: Structure-Based Analyses and Engineering to Increase Reduction Potential and Activity. Chemical Science (2025)

Jing-Xiang WangAvery C. VilbertLucas H. WilliamsEvan N. MirtsChang CuiYi Lu

chemical sciencesbioactive metalaxial methioninebiochemistrychemical biologytransition metal chemistrysmall laccasechemical structurebiophysical chemistrybiomolecular engineeringtype 1biological inorganic chemistry

2.6-Å Resolution Cryo-Em Structure of a Class Ia Ribonucleotide Reductase Trapped With Mechanism-Based Inhibitor N 3 Cdp. Proceedings of the National Academy of Sciences (2024)

Dana E. WestmorelandPatricia R. FelicianoGyunghoon KangChang CuiAlbert KimJoAnne StubbeDaniel G. NoceraCatherine L. Drennan

structural molecular biologyenzymeslong distanceprotein sciencealdo-keto reductasebiomolecular structurecryogenic electron microscopybiochemistrymolecular biophysicsenzyme inhibitionclass ia rnrsmolecular biologybiological chemistryprotein structurestructure-function enzyme kineticsnucleic acid chemistrybiophysical chemistrystructural biology

Increasing Reduction Potentials of Type 1 Copper Center and Catalytic Efficiency of Small Laccase From Streptomyces Coelicolor Through Secondary Coordination Sphere Mutations. Angewandte Chemie International Edition (2023)

Jing‐Xiang WangAvery C. VilbertChang CuiEvan N. MirtsLucas H. WilliamsWantae KimY. Jessie ZhangYi Lu

reduction potentialsenzymesenzyme catalysisbiochemistrychemical biologytransition metal chemistrybiochemical sciencesmolecular biologybiological chemistrysmall laccasemetalloproteinstype 1biological inorganic chemistry

Radical Transport Facilitated by a Proton Transfer Network at the Subunit Interface of Ribonucleotide Reductase. Journal of the American Chemical Society (2023)

Chang CuiDavid Y. SongCatherine L. DrennanJoAnne StubbeDaniel G. Nocera

enzymesaldo-keto reductasebiomolecular structureproton transfer networkbiochemistrymolecular biologystructure-function enzyme kineticsprotein structurestructural molecular biologysubunit interfacestructural biologyradical transport facilitated

Ribonucleotide Reductase, a Novel Drug Target for Gonorrhea. DSpace@MIT (Massachusetts Institute of Technology) (2022)

Jana NarasimhanSuzanne LetinskiStephen P JungAleksey GerasyutoJiashi WangMichael ArnoldGuangming ChenJean HedrickMelissa DumbleKanchana RavichandranTalya LevitzChang CuiCatherine L DrennanJoAnne StubbeGary KarpArthur Branstrom

clinical microbiologyribonucleotide reductaseantimicrobial agentsinfectious diseasesnovel drug targetng mapantimicrobial chemotherapyantibiotic resistanceantimicrobial resistancemicrobiologydrug resistanceantimicrobial resistance genestherapeutic targetsantibioticsenzyme inhibitiondrug discovery

19 F Electron-Nuclear Double Resonance Reveals Interaction Between Redox-Active Tyrosines Across the α/β Interface of E. Coli Ribonucleotide Reductase. Journal of the American Chemical Society (2022)

Andreas MeyerAnnemarie KehlChang CuiFehmke A. K. ReichardtFabian HeckerLisa-Marie FunkManas K. GhoshKuan-Ting PanHenning UrlaubKai TittmannJoAnne StubbeMarina Bennati

enzymescolinear pcetenzyme catalysisnucleic acidsredox biologybiochemistrydna replicationα/β interfacemolecular biologystructure-function enzyme kineticsprotein structureredox chemistrynucleic acid chemistrystructural molecular biologystructural biology

Author Response: Ribonucleotide Reductase, a Novel Drug Target for Gonorrhea. (2021)

nucleic acidsmicrobiologydrug resistancepharmacologydrug discoveryauthor responseenzyme inhibition

Gated Proton Release During Radical Transfer at the Subunit Interface of Ribonucleotide Reductase. Journal of the American Chemical Society (2020)

Chang CuiBrandon L. GreeneGyunghoon KangCatherine L. DrennanJoAnne StubbeDaniel G. Nocera

proton releasestructural molecular biologyenzymesredox biologybiochemistrymolecular biologybiological chemistryprotein structurestructure-function enzyme kineticsredox chemistryescherichia colibiophysical chemistrysubunit interface

Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets. Annual Review of Biochemistry (2020)

Brandon L. GreeneGyunghoon KangChang CuiMarina BennatiDaniel G. NoceraCatherine L. DrennanJoAnne Stubbe

structural molecular biologyenzymeslong distancemolecular metabolismbiomolecular structurenucleic acidsbiochemistryenzyme inhibitiondna replicationmolecular biologybiological chemistryprotein structurenucleic acid chemistryhuman rnrsdna repairrna biologystructural biologydrug discovery

Structural Basis for a Quadratic Relationship Between Electronic Absorption and Electronic Paramagnetic Resonance Parameters of Type 1 Copper Proteins. Inorganic Chemistry (2020)

Sheng-Song YuJun-Jie LiChang CuiShiliang TianJie-Jie ChenHan-Qing YuChangjun HouMark J. NilgesYi Lu

biophysicsphysicochemical analysisspectra-structure correlationprotein chemistryprotein sciencequadratic relationshipbiomolecular structurephysical chemistrychemistrymagnetic resonanceprotein structurestructural basismetalloproteinsmolecular structurebiophysical chemistrystructural biologytype 1

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Chang Cui

Assistant Professor of Biochemistry

University of Illinois Urbana-Champaign

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Biochemistry

Chang Cui is currently serving as a College Of Liberal Arts & Sciences Assistant Professor of Biochemistry at University of Illinois Urbana-Champaign.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Chang Cui

University of Illinois Urbana-Champaign

Assistant Professor of Biochemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Jing-Xiang WangAvery C. VilbertLucas H. WilliamsEvan N. MirtsChang CuiYi Lu

2.6-Å Resolution Cryo-Em Structure of a Class Ia Ribonucleotide Reductase Trapped With Mechanism-Based Inhibitor N 3 Cdp. Proceedings of the National Academy of Sciences (2024)

Dana E. WestmorelandPatricia R. FelicianoGyunghoon KangChang CuiAlbert KimJoAnne StubbeDaniel G. NoceraCatherine L. Drennan

Jing‐Xiang WangAvery C. VilbertChang CuiEvan N. MirtsLucas H. WilliamsWantae KimY. Jessie ZhangYi Lu

Radical Transport Facilitated by a Proton Transfer Network at the Subunit Interface of Ribonucleotide Reductase. Journal of the American Chemical Society (2023)

Chang CuiDavid Y. SongCatherine L. DrennanJoAnne StubbeDaniel G. Nocera

Ribonucleotide Reductase, a Novel Drug Target for Gonorrhea. DSpace@MIT (Massachusetts Institute of Technology) (2022)

Andreas MeyerAnnemarie KehlChang CuiFehmke A. K. ReichardtFabian HeckerLisa-Marie FunkManas K. GhoshKuan-Ting PanHenning UrlaubKai TittmannJoAnne StubbeMarina Bennati

Author Response: Ribonucleotide Reductase, a Novel Drug Target for Gonorrhea. (2021)

nucleic acidsmicrobiologydrug resistancepharmacologydrug discoveryauthor responseenzyme inhibition

Gated Proton Release During Radical Transfer at the Subunit Interface of Ribonucleotide Reductase. Journal of the American Chemical Society (2020)

Chang CuiBrandon L. GreeneGyunghoon KangCatherine L. DrennanJoAnne StubbeDaniel G. Nocera

Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets. Annual Review of Biochemistry (2020)

Brandon L. GreeneGyunghoon KangChang CuiMarina BennatiDaniel G. NoceraCatherine L. DrennanJoAnne Stubbe

Structural Basis for a Quadratic Relationship Between Electronic Absorption and Electronic Paramagnetic Resonance Parameters of Type 1 Copper Proteins. Inorganic Chemistry (2020)

Sheng-Song YuJun-Jie LiChang CuiShiliang TianJie-Jie ChenHan-Qing YuChangjun HouMark J. NilgesYi Lu

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small-molecule activation

coordination chemistry

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clinical microbiology

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