Faculty

Institution

Unit

Venue

Christopher Byron Brooke

Associate Professor of Microbiology Professor

UIUC

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Microbiology

Christopher Byron Brooke is currently serving as a College Of Liberal Arts & Sciences Associate Professor of Microbiology Professor at Uiuc.

Honors

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Experiences

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Education

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Christopher Byron Brooke

UIUC

Associate Professor of Microbiology Professor

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virus research infectious diseases virology general virology influenza medical virology immunology antiviral research communicable diseases viral pathogenesis sars-cov-2 viral evolution infectious diseases (medical specialty) pathogenesis influenza vaccine virus-host interactions covid-19 viral structural protein viral genetics epidemiology viral dynamics immunity (medicine) viral replication virus structure microbiology virus epidemiology viral diagnostics virus transmission flu vaccination influenza a virus vaccines antiviral responses molecular diagnostics infection control covid-19 pandemic genome biology structural molecular biology antiviral drug development emergent virus virus eradication nucleic acids antiviral drugs innate immune system influenza virus medicinal research public health preparedness cell research antiviral therapy infectious respiratory disease vaccine targets infectious disease modelling epidemiological dynamic next-generation sequencing high throughput sequencing vaccine safety vaccine efficacy diagnostic tests safe drugs daily longitudinal sampling influenza virus infection cdr h3 host cell heterogeneity bioinformatics pipeline vaccine breakthrough infections semi-infectious particles viral rna genomic rnas evolutionary potential virus infection deep mutational scanning theoretical biology mathematical bioscience antiviral compounds emerging infectious diseases diagnostic virology top hits systems biology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Impact of Inactivated Vaccine on Transmission and Evolution of H9N2 Avian Influenza Virus in Chickens. npj Vaccines (2025)

Zhe HuHui AiZhen WangShiyue HuangHonglei SunXinxin XuanMingyue ChenJinxiu WangWei YanJiayi SunJuan PuChristopher B BrookeKin-Chow ChangYipeng SunJinhua Liu

immunologyvaccinesvirus researchinactivated vaccinepoultry sciencegeneral virologyavian medicinepoultry diseasesvaccine developmentvirologyinfluenza vaccinevaccinationinfectious diseasesinfluenzaflu vaccinationvaccine researchvirus eradication

Intrinsic Oasl Expression Licenses Interferon Induction During Influenza a Virus Infection. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Joel Rivera-CardonaTarun MahajanNeeharika R. KakuturuQi Wen TeoJoseph LedererElizabeth A. ThayerElizabeth F. RowlandKyle HeimburgerJiayi SunCera A. McDonaldClayton K. MickelsonRyan A. LangloisNicholas C. WuOlgica MilenkovicSergei MaslovChristopher B. Brooke

general virologycell researchviral pathogenesisintrinsic oasl expressioncell biologyvirus-host interactionsinnate immune systemantiviral responsesimmune responsesinfluenzaintrinsic expressionmedical virologyimmunologic mechanismsinfluenza a virusimmunity (medicine)immunologytranscriptomevirus researchvirology

Probing the Functional Constraints of Influenza a Virus Nep by Deep Mutational Scanning. Cell Reports (2025)

Qi Wen TeoYiquan WangHuibin LvMichael S OadeKevin J MaoTimothy J C TanYang Wei HuanJoel Rivera-CardonaEvan K ShaoDanbi ChoiChaoyang WangZahra Tavakoli DarganiChristopher B BrookeAartjan J W Te VelthuisNicholas C Wu

virus researchdeep mutational scanningvirus structuremedical virologystructural biologygeneral virologyfunctional constraintsvirologyviral evolutionmolecular biologyinfectious diseasesinfluenza

The Fitness Consequences of Coinfection and Reassortment for Segmented Viruses Depend Upon Viral Genetic Structure. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Mireille FarjoChristopher B. Brooke

evolutionary applicationsvirus researchvirus-host interactionsgeneral virologydifferent strainsgeneticsevolutionary biologygenetic variationviral geneticsviral dynamicsvirologyviral evolutioncellular coinfectionmulti-strain coinfectionsinfectious diseasespopulation genetics

Cryptic Proteins Translated From Deletion-Containing Viral Genomes Dramatically Expand the Influenza Virus Proteome. Nucleic Acids Research (2024)

Jordan N RanumMitchell P LedwithFadi G AlnajiMeghan DiefenbacherRichard OrtonElizabeth SloanMelissa GüerecaElizabeth M FeltmanKatherine SmollettAna da Silva FilipeMichaela ConleyAlistair B RussellChristopher B BrookeEdward HutchinsonAndrew Mehle

immunologyvirus researchantiviral researchpathogenesisgeneral virologyviral pathogenesismolecular virologyviral geneticsvirologymany dprsinfectious diseasesinfluenzaviral replicationviral structural proteinfaithful replicationcryptic proteins

Deep Mutational Scanning of Influenza a Virus Nep Reveals Pleiotropic Mutations in Its N-Terminal Domain. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Qi Wen TeoYiquan WangHuibin LvKevin J. MaoTimothy J.C. TanYang Wei HuanJoel Rivera-CardonaEvan K. ShaoDanbi ChoiZahra Tavakoli DarganiChristopher B. BrookeNicholas C. Wu

virus researchprotein evolutiondeep mutational scanningvirus structuren-terminal domainreplication fitness effectsgeneral virologygeneticsviral geneticsvirologyviral evolutionmolecular biologystructural molecular biologyinfluenzaviral replicationmutagenesis (molecular biology technique)

Influenza a Viral Burst Size From Thousands of Infected Single Cells Using Droplet Quantitative Pcr (Dqpcr). PLoS Pathogens (2024)

Geoffrey K. ZathMallory M. ThomasEmma K. LovedayDimitri A. BikosSteven SancheRuian KeChristopher B. BrookeConnie B. Chang

virus researchcommunicable diseasesviral burst sizeflu virusinfection controlmedical virologygeneral virologyvirus epidemiologyviral dynamicsvirologydroplet quantitative pcrinfectious diseasesinfluenzavirus transmissionmicrobiologyinfectious diseases (medical specialty)viral diagnostics

Natural Variation in Neuraminidase Activity Influences the Evolutionary Potential of the Seasonal H1N1 Lineage Hemagglutinin. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Tongyu LiuWilliam K. ReiserTimothy J C TanHuibin LvJoel Rivera-CardonaKyle HeimburgerNicholas C WuChristopher B. Brooke

immunologyvirus researchnatural variationantiviral researchgeneral virologyvirologyviral evolutioninfluenza vaccinepdmh1n1 lineageinfectious diseasesinfluenzaviral structural proteinseasonal h1n1 lineage

Reviewer #3 (Public Review): Stratification of Viral Shedding Patterns in Saliva of Covid-19 Patients. (2024)

Hyeongki ParkRaiki YoshimuraShoya IwanamiKwang Su KimKeisuke EjimaNaotoshi NakamuraKazuyuki AiharaYoshitsugu MiyazakiTakashi UmeyamaKen MiyazawaTakeshi MoritaKoichi WatashiChristopher B. BrookeRuian KeShingo IwamiTaiga Miyazaki

virus researchcommunicable diseasessars-cov-2covid-19medical virologycontinued vigilanceepidemiologygeneral virologycovid-19 pandemicvirus epidemiologyviral dynamicsvirologypublic reviewinfectious diseasessaliva samplesinfectious diseases (medical specialty)viral diagnostics

Saliva-Based Molecular Testing for Sars-Cov-2. (2024)

Christopher Byron Brooke

immunologyvirus researchsars-cov-2covid-19medical virologygeneral virologyvirologyinfectious diseasessalivary glandsviral diagnostics

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Christopher Byron Brooke

Associate Professor of Microbiology Professor

UIUC

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Microbiology

Christopher Byron Brooke is currently serving as a College Of Liberal Arts & Sciences Associate Professor of Microbiology Professor at Uiuc.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Christopher Byron Brooke

UIUC

Associate Professor of Microbiology Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Impact of Inactivated Vaccine on Transmission and Evolution of H9N2 Avian Influenza Virus in Chickens. npj Vaccines (2025)

Zhe HuHui AiZhen WangShiyue HuangHonglei SunXinxin XuanMingyue ChenJinxiu WangWei YanJiayi SunJuan PuChristopher B BrookeKin-Chow ChangYipeng SunJinhua Liu

Intrinsic Oasl Expression Licenses Interferon Induction During Influenza a Virus Infection. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Probing the Functional Constraints of Influenza a Virus Nep by Deep Mutational Scanning. Cell Reports (2025)

virus researchdeep mutational scanningvirus structuremedical virologystructural biologygeneral virologyfunctional constraintsvirologyviral evolutionmolecular biologyinfectious diseasesinfluenza

The Fitness Consequences of Coinfection and Reassortment for Segmented Viruses Depend Upon Viral Genetic Structure. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Mireille FarjoChristopher B. Brooke

Cryptic Proteins Translated From Deletion-Containing Viral Genomes Dramatically Expand the Influenza Virus Proteome. Nucleic Acids Research (2024)

Deep Mutational Scanning of Influenza a Virus Nep Reveals Pleiotropic Mutations in Its N-Terminal Domain. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Qi Wen TeoYiquan WangHuibin LvKevin J. MaoTimothy J.C. TanYang Wei HuanJoel Rivera-CardonaEvan K. ShaoDanbi ChoiZahra Tavakoli DarganiChristopher B. BrookeNicholas C. Wu

Influenza a Viral Burst Size From Thousands of Infected Single Cells Using Droplet Quantitative Pcr (Dqpcr). PLoS Pathogens (2024)

Geoffrey K. ZathMallory M. ThomasEmma K. LovedayDimitri A. BikosSteven SancheRuian KeChristopher B. BrookeConnie B. Chang

Natural Variation in Neuraminidase Activity Influences the Evolutionary Potential of the Seasonal H1N1 Lineage Hemagglutinin. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Tongyu LiuWilliam K. ReiserTimothy J C TanHuibin LvJoel Rivera-CardonaKyle HeimburgerNicholas C WuChristopher B. Brooke

Reviewer #3 (Public Review): Stratification of Viral Shedding Patterns in Saliva of Covid-19 Patients. (2024)

Saliva-Based Molecular Testing for Sars-Cov-2. (2024)

Christopher Byron Brooke

immunologyvirus researchsars-cov-2covid-19medical virologygeneral virologyvirologyinfectious diseasessalivary glandsviral diagnostics

1
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4
5
8
10 / page