Faculty

Institution

Unit

Venue

Catherine Freudenreich

Professor

Tufts University

Affiliations

School of Arts and Sciences

Biology

Graduate School of Biomedical Sciences

Genetics, Molecular and Cellular Biology

Graduate School of Arts and Sciences

Catherine Freudenreich is currently serving as a Biology Professor at Tufts University.

Honors

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Experiences

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Education

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Catherine Freudenreich

Tufts University

Professor

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molecular biology genetics genome biology dna repair molecular genetics structural biology genome instability cell biology genomics neuroscience yeast replication gene expression nucleic acids molecular cell biology cancer genetics cytogenetics chromosome biology cancer research molecular and cellular biology structural molecular biology cancer biology rna biology protein science biomolecular structure cell cycle collapsed forks nuclear periphery molecular cancer fungal genetics chromatin remodeling nuclear organization repeat instability repeat fragility genome stability enzyme inhibition molecular structure gene regulation gene function mutagenesis molecular basis animal genetics epigenetic changes cancer genomics repeat expansions fork stalling triplet repeat stability dna structures chromosome fragility natural replication barriers nature method nature nuclear science cancer care social science research biological chemistry cell regulation molecular regulation cellular biology molecular biotechnology tumor targeting anti-cancer agents drug targeting oncogenic agent recombination dynamic protein misfolding structural bioinformatics molecular fragmentation epigenomics hla typing molecular evidence ctg repeats length-dependent fragility wrn dependence microsatellite-unstable cancers chromosome breakage

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Novel Ilp Framework to Identify Compensatory Pathways in Genetic Interaction Networks With Gideon. bioRxiv (Cold Spring Harbor Laboratory) (2026)

genome biologyregulatory network modellingnovel ilp frameworkgene expressionomicsinteractomicsfunctional genomicsgene regulatory networksidentify compensatory pathwayssystems biologygeneticsgenetic interaction networksbiological networkstheoretical biologypathway analysismolecular informatics

Cruciform-Forming at/Ta Repeats Are Acted Upon by Structure-Selective Endonucleases and Rad51 Prior to Repositioning to the Nuclear Periphery for Repair. Nucleic Acids Research (2026)

nucleic acid chemistrynuclear peripherygeneticsstructure-selective endonucleasesmolecular cell biologycruciform-forming at/ta repeatsmolecular geneticsmolecular biologystructural molecular biologychromatin remodelingdna repairbiomolecular structurenuclear organizationgenome instabilitychromatinnucleic acids

Apobec3A Deaminates Ctg Hairpin Loops to Promote Fragility and Instability of Expanded Cag/Ctg Repeats. Proceedings of the National Academy of Sciences (2025)

Rebecca E. BrownMargo CoxonBenjamin LarsenMaxwell AllisonAriana ChadhaIsabelle MittelstadtTony M. MertzSteven A. RobertsCatherine H. Freudenreich

biophysicsprotein structuremolecular biologystructural biologyctg hairpin loopsgenome instabilityprotein folding

Overcoming Natural Replication Barriers Formed by Dna Structures and the Role of Repositioning to the Nuclear Periphery. DNA repair (2025)

genome biologynucleic acid chemistrynatural replication barriersnuclear peripherygeneticsbiomolecular structuremolecular cell biologymolecular biologydna structuresdna repairdna replicationnuclear organizationgenome instabilitychromatinnucleic acids

The Dna Replication Checkpoint Targets the Kinetochore to Reposition Dna Structure-Induced Replication Damage to the Nuclear Periphery. Cell Reports (2025)

cell cyclegeneticscell divisionmolecular cell biologydna repairnucleic acidsmolecular biologychromatin remodelingchromatindna replicationnuclear organizationdna replication checkpointnuclear peripherygenome instabilitycell biology

Time and Space: How the Circadian Clock Controls Dna Break Repair Location and Pathway Choice. Molecular Cell (2025)

pathway choicechronobiologycell cyclemolecular and cellular biologymolecular cell biologynucleic acidsmolecular biologydna repairhomeostatic mechanismsrepair locationgenome instabilitychromatincell biology

C9Orf72 Expansion Creates the Unstable Folate-Sensitive Fragile Site Fra9a. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Mila MircetaMonika H.M. SchmidtNatalie ShumTanya K. PrasolavaBryanna MeikleStella LanniMohiuddin MohiuddinPaul M. MckeeverMing ZhangMinggao LiangIlse van der WerfStefaan ScheersPatrick A. DionPeixiang WangMichael D. WilsonTheresa AbellElliot A. PhilipsŁukasz J. SznajderMaurice S. SwansonMustafa MehkaryMahreen KhanKatsuyuki YokoiChristine JungPieter J. de JongCatherine H. FreudenreichPhilip McGoldrickRyan K.C. YuenAgessandro AbrahãoJulia KeithLorne ZinmanJanice RobertsonEkaterina RogaevaGuy A. RouleauR. Frank KooyChristopher E. Pearson

genome biologygene expressionbiophysicsprotein structuremolecular biologymolecular geneticsdna repairstructural biologygenome instabilitybiochemistry

Dna Polymerase Zeta Can Efficiently Replicate Structures Formed by at/Ta Repeat Sequences and Prevent Their Deletion. Nucleic Acids Research (2024)

Mili DasSuzanne E HileJennifer BrewsterJan Leendert BoerRachel Bezalel-BuchQiong GuoWei YangPeter M BurgersKristin A EckertCatherine H Freudenreich

dna replicationdna polymerase zetamolecular biologynucleic acids

The Dna Replication Checkpoint Targets the Kinetochore for Relocation of Collapsed Forks to the Nuclear Periphery. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Tyler MaclayJenna WhalenMatthew JohnsonCatherine H. Freudenreich

systems biologybiologymolecular biologydna damage checkpointdna repaircollapsed forks

The Dna Replication Checkpoint Targets the Kinetochore for Relocation of Collapsed Forks to the Nuclear Periphery. (2024)

Tyler MaclayJenna WhalenMatthew JohnsonCatherine Freudenreich

molecular biologydna replication checkpointdna replicationnuclear peripherycollapsed forks

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Catherine Freudenreich

Professor

Tufts University

Affiliations

School of Arts and Sciences

Biology

Graduate School of Biomedical Sciences

Genetics, Molecular and Cellular Biology

Graduate School of Arts and Sciences

Catherine Freudenreich is currently serving as a Biology Professor at Tufts University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Catherine Freudenreich

Tufts University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Novel Ilp Framework to Identify Compensatory Pathways in Genetic Interaction Networks With Gideon. bioRxiv (Cold Spring Harbor Laboratory) (2026)

Cruciform-Forming at/Ta Repeats Are Acted Upon by Structure-Selective Endonucleases and Rad51 Prior to Repositioning to the Nuclear Periphery for Repair. Nucleic Acids Research (2026)

Apobec3A Deaminates Ctg Hairpin Loops to Promote Fragility and Instability of Expanded Cag/Ctg Repeats. Proceedings of the National Academy of Sciences (2025)

Rebecca E. BrownMargo CoxonBenjamin LarsenMaxwell AllisonAriana ChadhaIsabelle MittelstadtTony M. MertzSteven A. RobertsCatherine H. Freudenreich

biophysicsprotein structuremolecular biologystructural biologyctg hairpin loopsgenome instabilityprotein folding

Overcoming Natural Replication Barriers Formed by Dna Structures and the Role of Repositioning to the Nuclear Periphery. DNA repair (2025)

The Dna Replication Checkpoint Targets the Kinetochore to Reposition Dna Structure-Induced Replication Damage to the Nuclear Periphery. Cell Reports (2025)

Time and Space: How the Circadian Clock Controls Dna Break Repair Location and Pathway Choice. Molecular Cell (2025)

C9Orf72 Expansion Creates the Unstable Folate-Sensitive Fragile Site Fra9a. bioRxiv (Cold Spring Harbor Laboratory) (2024)

genome biologygene expressionbiophysicsprotein structuremolecular biologymolecular geneticsdna repairstructural biologygenome instabilitybiochemistry

Dna Polymerase Zeta Can Efficiently Replicate Structures Formed by at/Ta Repeat Sequences and Prevent Their Deletion. Nucleic Acids Research (2024)

Mili DasSuzanne E HileJennifer BrewsterJan Leendert BoerRachel Bezalel-BuchQiong GuoWei YangPeter M BurgersKristin A EckertCatherine H Freudenreich

dna replicationdna polymerase zetamolecular biologynucleic acids

The Dna Replication Checkpoint Targets the Kinetochore for Relocation of Collapsed Forks to the Nuclear Periphery. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Tyler MaclayJenna WhalenMatthew JohnsonCatherine H. Freudenreich

systems biologybiologymolecular biologydna damage checkpointdna repaircollapsed forks

The Dna Replication Checkpoint Targets the Kinetochore for Relocation of Collapsed Forks to the Nuclear Periphery. (2024)

Tyler MaclayJenna WhalenMatthew JohnsonCatherine Freudenreich

molecular biologydna replication checkpointdna replicationnuclear peripherycollapsed forks

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Similar Faculty Members

David Cortez

Institution

Vanderbilt University

genome maintenance

molecular cancer

Wolf-Dietrich Heyer

Institution

University of California, Davis

homologous recombination

genome instability

Jasper Rine

Institution

University of California, Berkeley

epigenetic mechanisms

chromatin remodeling

Nancy Kleckner

Institution

Harvard University

developmental biology

super-resolution time-lapse microscopy

Virginia A. Zakian

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genomics

yeast

James Haber

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Brandeis University

genome instability

recombination dynamic

Lucio Comai

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cellular senescence

gene expression

Andrew Emili

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interactomics

biomedical informatics

Walter Chazin

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molecular biology

proteomics

Norman Arnheim

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human genome project

human genetics