Faculty

Institution

Unit

Venue

Carlos A. Castaneda

Associate Professor Assistant Professor

Syracuse University

Affiliations

College of Arts and Sciences

Biology

Chemistry

Neuroscience

Carlos A. Castaneda is currently serving as a Biology Associate Professor Assistant Professor at Syracuse University.

Honors

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Experiences

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Education

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Carlos A. Castaneda

Syracuse University

Associate Professor Assistant Professor

You can click a keyword to filter the displayed items

molecular biology structural biology biophysics protein science protein structure biochemistry molecular biophysics phase separation biomolecular engineering structural molecular biology membrane biology proteomics protein chemistry protein function analytical chemistry medicinal chemistry molecular structure molecular science liquid-liquid phase separation physical chemistry biomolecular structure structural chemistry enzyme inhibition protein transport hydrophobic interior als-linked mutations biochemical sciences peptide science conformational studies proteinlipid interaction structural composition biomolecular interactions protein phase separation protein assembly molecular evidence nonenzymatic assembly hydrophobic core ubiquitin chains major regulators molecular cell biology material chemistry solid-state electronics electronic materials chemical sciences molecular physiology peptides fragmentation effect amphiphilic system fluid-structure interaction structural integrity solid-state chemistry damage mechanism protein genetics key site structure elucidation in vivo systems intercellular communication gene regulatory networks muscle function molecular regulation chemical biotechnology biochemical interaction protein modeling enzyme specificity protein bioinformatics host specificity neurochemistry large shifts lysine residues multivalent interactions molecular determinants staphylococcal nuclease different factors pka values basic residues same internal location proteome research biomolecular structure prediction protein homeostasis biomolecular analysis amyotrophic lateral sclerosis

Notable Scholarly Works

Notable Federal Grants

Collaborators

Molecular Basis for Yeast Ubiquilin Dsk2 Self-Association and Phase Separation. Biophysical Journal (2024)

Nirbhik AcharyaThuy P. DaoErica MallonErin MulveyDan KrautCarlos A. Castaneda

biophysicsphase separationmolecular sciencemolecular biophysicsmembrane biologyyeastmolecular basismolecular biologybiophysical chemistrymolecular self-assemblystructural biologygenetics

Pathogenic Mutations in Ubqln2 Exhibit Diverse Aggregation Propensity and Neurotoxicity. Scientific Reports (2024)

Nathaniel SafrenThuy P DaoHarihar Milaganur MohanCamellia HuangBryce TrotterCarlos A CastañedaHenry PaulsonSami BarmadaLisa M Sharkey

neurologypathologypathogenesispathogenic mutationsgenetics

Phase Separation of Polyubiquitinated Proteins in Ubqln2 Condensates Controls Substrate Fate. Proceedings of the National Academy of Sciences (2024)

Isabella M. ValentinoJeniffer G. Llivicota-GuamanThuy P. DaoErin O. MulveyAndrew M. LehmanSarasi K. K. GalagederaErica L. MallonCarlos A. CastañedaDaniel A. Kraut

polyubiquitinated proteinsphase separationstructural biologymolecular biology

Short, Disordered N-Termini and the Proline-Rich Region Are Major Regulators of Ubqln1, Ubqln2 and Ubqln4 Phase Transitions. Biophysical Journal (2024)

Thuy P. DaoAnitha RajendranSarasi GalagederaWilliam HawsCarlos A. Castaneda

biophysicsproline-rich regionbiochemistrymolecular biophysicsmolecular biologyplant sciencebiophysical chemistrymajor regulators

Single Point Mutations in Disordered Proteins: Linking Sequence, Ensemble, and Function. (2024)

Eduardo FloresNirbhik AcharyaCarlos CastanedaShahar Sukenik

biophysicsprotein sciencefunctional modificationlinkage disequilibriumprotein assemblydisordered proteinssingle point mutationsmolecular biologyprotein structuresystems biologystructural molecular biologystructural biology

Vimentin is a Key Regulator of Cell Mechanosensing Through Opposite Actions on Actomyosin and Microtubule Networks. Communications Biology (2024)

Farid AlisafaeiKalpana MandalRenita SaldanhaMaxx SwogerHaiqian YangXuechen ShiMing GuoHeidi HehnlyCarlos A. CastañedaPaul A. JanmeyAlison E. PattesonVivek B. Shenoy

muscle functioncell signalingopposite actionscell biologycellular physiologyneuroscienceprotein functioncommunicationneurophysiologyintercellular communicationmicrotubule networkssignal transductionmolecular regulationgene regulatory networkskey regulator

Decoding Optimal Ligand Design for Multicomponent Condensates. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Sarasi K. K. GalagederaThuy P. DaoSuzanne E. EnosAntara ChaudhuriJeremy D. SchmitCarlos A. Castañeda

multicomponent condensatesmedicinal chemistryoptimal ligand designpharmacologymolecular biologybiomolecular engineering

Ion Mobility Mass Spectrometry Unveils Global Protein Conformations in Response to Conditions That Promote and Reverse Liquid–Liquid Phase Separation. Journal of the American Chemical Society (2023)

Christina Glen RobbThuy P. DaoJakub UjmaCarlos A. CastañedaRebecca Beveridge

biophysicsproteomicsglobal protein conformationschemical engineeringprotein scienceanalytical chemistryliquid-liquid phase separationmass spectrometrymaterials science

Polyubiquitin Ligand-Induced Phase Transitions Are Optimized by Spacing Between Ubiquitin Units. Proceedings of the National Academy of Sciences (2023)

Sarasi K. K. GalagederaThuy P. DaoSuzanne E. EnosAntara ChaudhuriJeremy D. SchmitCarlos A. Castañeda

biophysicsubiquitin unitsmolecular biologystructural biologymaterials science

Short Disordered Termini and Proline-Rich Domain Are Major Regulators of Ubqln1/2/4 Phase Separation. Biophysical Journal (2023)

Thuy P. DaoAnitha RajendranSarasi K.K. GalagederaWilliam HawsCarlos A. Castañeda

biophysicsproline-rich domainneurosciencemolecular biophysicsmolecular biologymajor regulatorsphase separation

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Carlos A. Castaneda

Associate Professor Assistant Professor

Syracuse University

Affiliations

College of Arts and Sciences

Biology

Chemistry

Neuroscience

Carlos A. Castaneda is currently serving as a Biology Associate Professor Assistant Professor at Syracuse University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Carlos A. Castaneda

Syracuse University

Associate Professor Assistant Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Molecular Basis for Yeast Ubiquilin Dsk2 Self-Association and Phase Separation. Biophysical Journal (2024)

Nirbhik AcharyaThuy P. DaoErica MallonErin MulveyDan KrautCarlos A. Castaneda

biophysicsphase separationmolecular sciencemolecular biophysicsmembrane biologyyeastmolecular basismolecular biologybiophysical chemistrymolecular self-assemblystructural biologygenetics

Pathogenic Mutations in Ubqln2 Exhibit Diverse Aggregation Propensity and Neurotoxicity. Scientific Reports (2024)

Nathaniel SafrenThuy P DaoHarihar Milaganur MohanCamellia HuangBryce TrotterCarlos A CastañedaHenry PaulsonSami BarmadaLisa M Sharkey

neurologypathologypathogenesispathogenic mutationsgenetics

Phase Separation of Polyubiquitinated Proteins in Ubqln2 Condensates Controls Substrate Fate. Proceedings of the National Academy of Sciences (2024)

Isabella M. ValentinoJeniffer G. Llivicota-GuamanThuy P. DaoErin O. MulveyAndrew M. LehmanSarasi K. K. GalagederaErica L. MallonCarlos A. CastañedaDaniel A. Kraut

polyubiquitinated proteinsphase separationstructural biologymolecular biology

Short, Disordered N-Termini and the Proline-Rich Region Are Major Regulators of Ubqln1, Ubqln2 and Ubqln4 Phase Transitions. Biophysical Journal (2024)

Thuy P. DaoAnitha RajendranSarasi GalagederaWilliam HawsCarlos A. Castaneda

biophysicsproline-rich regionbiochemistrymolecular biophysicsmolecular biologyplant sciencebiophysical chemistrymajor regulators

Single Point Mutations in Disordered Proteins: Linking Sequence, Ensemble, and Function. (2024)

Eduardo FloresNirbhik AcharyaCarlos CastanedaShahar Sukenik

Vimentin is a Key Regulator of Cell Mechanosensing Through Opposite Actions on Actomyosin and Microtubule Networks. Communications Biology (2024)

Farid AlisafaeiKalpana MandalRenita SaldanhaMaxx SwogerHaiqian YangXuechen ShiMing GuoHeidi HehnlyCarlos A. CastañedaPaul A. JanmeyAlison E. PattesonVivek B. Shenoy

Decoding Optimal Ligand Design for Multicomponent Condensates. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Sarasi K. K. GalagederaThuy P. DaoSuzanne E. EnosAntara ChaudhuriJeremy D. SchmitCarlos A. Castañeda

multicomponent condensatesmedicinal chemistryoptimal ligand designpharmacologymolecular biologybiomolecular engineering

Christina Glen RobbThuy P. DaoJakub UjmaCarlos A. CastañedaRebecca Beveridge

biophysicsproteomicsglobal protein conformationschemical engineeringprotein scienceanalytical chemistryliquid-liquid phase separationmass spectrometrymaterials science

Polyubiquitin Ligand-Induced Phase Transitions Are Optimized by Spacing Between Ubiquitin Units. Proceedings of the National Academy of Sciences (2023)

Sarasi K. K. GalagederaThuy P. DaoSuzanne E. EnosAntara ChaudhuriJeremy D. SchmitCarlos A. Castañeda

biophysicsubiquitin unitsmolecular biologystructural biologymaterials science

Short Disordered Termini and Proline-Rich Domain Are Major Regulators of Ubqln1/2/4 Phase Separation. Biophysical Journal (2023)

Thuy P. DaoAnitha RajendranSarasi K.K. GalagederaWilliam HawsCarlos A. Castañeda

biophysicsproline-rich domainneurosciencemolecular biophysicsmolecular biologymajor regulatorsphase separation

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metallodrug discovery

transition metal chemistry

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University of California, Los Angeles

virulence factors

microbial pathogenesis

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molecular metabolism

protein structure

David Fushman

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systems biology

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membrane system

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metabolic profiles

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