Faculty

Institution

Unit

Venue

Myles Cabot

Research Professor

East Carolina University

Affiliations

Brody School of Medicine

Biochemistry and Molecular Biology

Myles Cabot is currently serving as a Biochemistry And Molecular Biology Research Professor at East Carolina University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Myles Cabot

East Carolina University

Research Professor

You can click a keyword to filter the displayed items

pharmacology oncology cancer research cell biology cancer biology tumor biology cancer treatment medicinal research medicine anti-cancer agents pharmacotherapy enzyme inhibition cell death cancer care tumor targeting biochemistry therapeutic targets membrane biology leukemia drug resistance cancer cells cell signaling apoptosis medicinal chemistry molecular cancer cellular therapy acute myeloid leukemia cell metabolism hematological malignancies glucosylceramide synthase cancer management lipid science myeloid neoplasia drug targeting cell regulation pharmacological research protein science acid ceramidase redox biology cellular biochemistry clinical pharmacology mitochondrial function pancreatic cancer ceramide glycosylation biological chemistry lipid chemistry breast oncology colorectal cancer therapeutic efficacy functional modification molecular physiology cancer genetics sphingolipid metabolism cancer growth clinical therapeutics glycosylation cell therapy therapy resistance human cancer cells ceramide generation cellular bioenergetics inhibitory activity molecular regulation oncogenic agent cellular biology lipid analysis endocrine oncology cytokines cancer drug resistance serine palmitoyltransferase multidrug resistance modulator drug-resistant cancer cells ceramide-based therapeutics cellular ceramide formation short-chain ceramide sl metabolism

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 4740: Acid Ceramidase Inhibition Enhances Venetoclax Sensitivity in Preclinical Models of Acute Myeloid Leukemia. Cancer Research (2024)

Johnson UngSu-Fern TanJeremy J. ShawTodd E. FoxMaansi TaoriDavid F. ClaxtonKelsey H. Fisher-WellmanMyles C. CabotDavid J. FeithThomas P. Loughran

venetoclax sensitivityclinical researchcell biologyhematologycancer biologycancer researchmolecular medicinecancer genomicsvascular biologyneurologypharmacologycancer treatmentoncologycellular therapyhematological malignanciescancer carecancer managementacid ceramidase inhibitionacute myeloid leukemiapreclinical modelsenzyme inhibitionmedicinal research

Acute Myeloid Leukemia Mitochondria Hydrolyze Atp to Resist Chemotherapy. bioRxiv (Cold Spring Harbor Laboratory) (2024)

James T HagenMclane M MontgomeryRaphael T ArulebaBrett R ChrestThomas D GreenMiki KassaiTonya N ZeczyckiCameron A SchmidtDebajit BhowmickSu-Fern TanDavid J FeithCharles E ChalfantThomas P LoughranDarla LilesMark D MindenAaron D SchimmerMyles C CabotJoseph M MclungKelsey H Fisher-Wellman

cancer biologymembrane biologymolecular cell biologymedicinegene expressionsignal transductionmitochondrial functiononcologycell metabolismmolecular metabolismmolecular biologycellular physiologycellular therapycell therapycell biologyenzymescellular biologyin vivo systems

Acute Myeloid Leukemia Stratifies as 2 Clinically Relevant Sphingolipidomic Subtypes. Blood Advances (2024)

B. Bishal PaudelSu-Fern TanTodd E. FoxJohnson UngUpendarrao GollaJeremy J. P. ShawWendy DuntonIrene LeeWisam A. FaresSatyam PatelArati SharmaAaron D. VinyBrian M. BarthMartin S. TallmanMyles CabotFrancine E. Garrett-BakelmanRoss L. LevineMark KesterDavid J. FeithDavid ClaxtonKevin A. JanesThomas P. Loughran

medicinehematologyleukemiamyeloid neoplasiahematological malignanciesrelevant sphingolipidomic subtypes

The Drug Transporter P-Glycoprotein and Its Impact on Ceramide Metabolism—an Unconventional Ally in Cancer Treatment. International Journal of Molecular Sciences (2024)

Johnson UngMiki KassaiSu-Fern TanThomas P. LoughranDavid J. FeithMyles C. Cabot

ceramide metabolismmolecular biologymolecular sciencedrug metabolismdrug transporter p-glycoprotein

Acid Ceramidase Inhibitor Lcl-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia. Cancers (2023)

Johnson UngSu-Fern TanTodd E. FoxJeremy J. P. ShawMaansi TaoriBethany J. HortonUpendarrao GollaArati SharmaZdzislaw M. SzulcHong-Gang WangCharles E. ChalfantMyles C. CabotDavid F. ClaxtonThomas P. LoughranDavid J. Feith

acute myeloid leukemianeurologypharmacologycancer biologyhealth sciencescancer researchoncologycell deathiron-dependent cell deathhematology

Data From Ceramide Analogue Saclac Modulates Sphingolipid Levels and I MCL-1 /I Splicing to Induce Apoptosis in Acute Myeloid Leukemia. (2023)

Jennifer M. PearsonSu-Fern TanArati SharmaCharyguly AnnageldiyevTodd E. FoxJose Luis AbadGemma FabriasDhimant DesaiShantu AminHong-Gang WangMyles C. CabotDavid F. ClaxtonMark KesterDavid J. FeithThomas P. Loughran

host specificitybiomolecular interactionshematologyprotein sciencemembrane biologymolecular medicinefunctional modificationvascular biologycell deathpharmacologygene expressionsphingolipid levelsimmunologyapoptosisacute myeloid leukemiaenzyme inhibitionmolecular biologysplicing variantcell signalingmedicinal researchceramide analogue saclac

Pan-Tissue Mitochondrial Phenotyping Reveals Lower Oxphos Expression and Function Across Cancer Types. Scientific Reports (2023)

Ilya N. BoykovMcLane M. MontgomeryJames T. HagenRaphael T. ArulebaKelsey L. McLaughlinHannah S. CoalsonMargaret A. NelsonAndrea S. PereyraJessica M. EllisTonya N. ZeczyckiNasreen A. VohraSu-Fern TanMyles C. CabotKelsey H. Fisher-Wellman

scientific datascience studiesoxidative stresscell regulationcell biologycancer biologymembrane biologycancer researchcancer typescell metabolismmolecular physiologycancer genomicstumor biologyoncologyredox biologyimmunologycancer caremitochondrial functionmolecular biology

Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia. Cancers (2023)

Kelsey H. Fisher-WellmanMiki KassaiJames T. HagenP. Darrell NeuferMark KesterThomas P. LoughranCharles E. ChalfantDavid J. FeithSu-Fern TanTodd E. FoxJohnson UngGemma FabriasJose’ Luis AbadArati SharmaUpendarrao GollaDavid F. ClaxtonJeremy J. P. ShawDebajit BhowmickMyles C. Cabot

glycosylationdrug resistanceanti-cancer agentssignal caspasecancer biologycancer researchceramide hydrolysismolecular physiologytumor biologycell deathpharmacologyoncologycancer geneticscancer caremitochondrial functionhealth sciencessimultaneous inhibitionenzyme inhibitionmolecular biologycell signalingmitochondrial respirationmedicinal research

Supplementary Appendix Including Cell Line Rrids and Supplementary Figures From Ceramide Analogue Saclac Modulates Sphingolipid Levels and I MCL-1 /I Splicing to Induce Apoptosis in Acute Myeloid Leukemia. (2023)

host specificityhematologyprotein sciencehepatologymembrane biologyfunctional modificationcell line rridsdermatologycell deathpharmacologygene expressiononcologysphingolipid levelssupplementary appendiximmunologyhematological malignanciesapoptosisacute myeloid leukemiaenzyme inhibitionsplicing variantceramide analogue saclac

Ceramide Nanoliposomes Augment the Efficacy of Venetoclax and Cytarabine in Models of Acute Myeloid Leukemia. The FASEB Journal (2022)

Andrei V. KhokhlatchevArati SharmaTye G. DeeringJeremy J. P. ShawPedro Costa‐PinheiroUpendarrao GollaCharyguly AnnageldiyevMyles C. CabotMark R. ConawaySu‐Fern TanJohnson UngDavid J. FeithThomas P. LoughranDavid F. ClaxtonTodd E. FoxMark Kester

nanoparticle researchpharmacologynanomedicinenanotechnologycancer treatmentdrug discoveryacute myeloid leukemiacancer researchoncologyneuroscienceanticoagulantsdrug targetingpharmacotherapytherapeutic efficacycellular therapymedicinal researchcell therapycell biology

1
2
3
4
5
12
10 / page

Myles Cabot

Research Professor

East Carolina University

Affiliations

Brody School of Medicine

Biochemistry and Molecular Biology

Myles Cabot is currently serving as a Biochemistry And Molecular Biology Research Professor at East Carolina University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Myles Cabot

East Carolina University

Research Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 4740: Acid Ceramidase Inhibition Enhances Venetoclax Sensitivity in Preclinical Models of Acute Myeloid Leukemia. Cancer Research (2024)

Johnson UngSu-Fern TanJeremy J. ShawTodd E. FoxMaansi TaoriDavid F. ClaxtonKelsey H. Fisher-WellmanMyles C. CabotDavid J. FeithThomas P. Loughran

Acute Myeloid Leukemia Mitochondria Hydrolyze Atp to Resist Chemotherapy. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Acute Myeloid Leukemia Stratifies as 2 Clinically Relevant Sphingolipidomic Subtypes. Blood Advances (2024)

medicinehematologyleukemiamyeloid neoplasiahematological malignanciesrelevant sphingolipidomic subtypes

The Drug Transporter P-Glycoprotein and Its Impact on Ceramide Metabolism—an Unconventional Ally in Cancer Treatment. International Journal of Molecular Sciences (2024)

Johnson UngMiki KassaiSu-Fern TanThomas P. LoughranDavid J. FeithMyles C. Cabot

ceramide metabolismmolecular biologymolecular sciencedrug metabolismdrug transporter p-glycoprotein

Acid Ceramidase Inhibitor Lcl-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia. Cancers (2023)

acute myeloid leukemianeurologypharmacologycancer biologyhealth sciencescancer researchoncologycell deathiron-dependent cell deathhematology

Data From Ceramide Analogue Saclac Modulates Sphingolipid Levels and I MCL-1 /I Splicing to Induce Apoptosis in Acute Myeloid Leukemia. (2023)

Pan-Tissue Mitochondrial Phenotyping Reveals Lower Oxphos Expression and Function Across Cancer Types. Scientific Reports (2023)

Ceramide Nanoliposomes Augment the Efficacy of Venetoclax and Cytarabine in Models of Acute Myeloid Leukemia. The FASEB Journal (2022)

1
2
3
4
5
12
10 / page

Similar Faculty Members

Yubin Ge

Institution

Wayne State University

hematology

down syndrome

Lisa Polin

Institution

Wayne State University

pharmacology

oncology

Lee Graves

Institution

University of North Carolina at Chapel Hill

molecular biology

pharmacology

Donald McDonnell

Institution

Duke University

pharmacology

endocrinology

Puttur Prasad

Institution

Augusta University

chemoprevention strategies

cancer biology

Devanand Sarkar

Institution

Virginia Commonwealth University

oncology

cancer research

Said M. Sebti

Institution

Virginia Commonwealth University

receptor tyrosine kinase

molecular cancer

Sarah Spiegel

Institution

Virginia Commonwealth University

signaling pathway

cancer cell

Ritu Aneja

Institution

University of Alabama at Birmingham

oncology

cancer research

Larry Matherly

Institution

Wayne State University

pharmacology

medicinal research

Similar Faculty Members

Yubin Ge

Institution

Wayne State University

hematology

down syndrome

Lisa Polin

Institution

Wayne State University

pharmacology

oncology

Lee Graves

Institution

University of North Carolina at Chapel Hill

molecular biology

pharmacology

Donald McDonnell

Institution

Duke University

pharmacology

endocrinology

Puttur Prasad

Institution

Augusta University

chemoprevention strategies

cancer biology

Devanand Sarkar

Institution

Virginia Commonwealth University

oncology

cancer research

Said M. Sebti

Institution

Virginia Commonwealth University

receptor tyrosine kinase

molecular cancer

Sarah Spiegel

Institution

Virginia Commonwealth University

signaling pathway

cancer cell

Ritu Aneja

Institution

University of Alabama at Birmingham

oncology

cancer research

Larry Matherly

Institution

Wayne State University

pharmacology

medicinal research