Faculty

Institution

Unit

Venue

Leslie Bruggeman

Professor Professor of Molecular Medicine

Case Western Reserve University

Affiliations

School of Medicine

Molecular Medicine

Leslie Bruggeman is currently serving as a Molecular Medicine Professor Professor of Molecular Medicine at Case Western Reserve University.

Honors

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Experiences

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Education

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Leslie Bruggeman

Case Western Reserve University

Professor Professor of Molecular Medicine

You can click a keyword to filter the displayed items

nephrology cell biology hiv virology medicine vascular biology neurology gene expression membrane biology renal function immunology cellular physiology medicinal research renal pathophysiology hematology mammalian biology inflammation viral genetics cell signaling protein science renal care molecular physiology hiv-associated nephropathy virus research general virology liver physiology viral pathogenesis medical virology respiratory medicine kidney research clinical microbiology biological chemistry cell regulation antiviral research cell physiology mouse model clinical investigation stem cell research virus-host interactions human retrovirus protein expression viral evolution cellular biology rna biology host factors apoptosis gene function andrology cell adhesion molecular regulation transgenic mice disease transmission viral replication molecular virology gene transfer clinical medicine membrane transport fibroblast growth factors angiogenesis tissue physiology integrative biology biomolecular interactions protein transport molecular therapy nuclear hormone receptors transgenic models renal cells unrecognized site renal epithelium renal reservoir primary infection kidney epithelium progressive glomerulosclerosis basement membrane components renal accumulation mice transgenic human genetics genetics molecular diagnostics genetic epidemiology immune-related gene polymorphism chronic kidney disease epidemiology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Analysis of Glomerular Transcriptomes From Nephrotic Patients Suggest Apol1 Risk Variants Impact Parietal Epithelial Cells. medRxiv (2024)

Agustin Gonzalez-VicenteDana C. CrawfordWilliam S. BushZhenzhen WuLeslie A. BruggemanViji NairFelix EichingerOliver WesselyMatthias KretzlerJohn F. O’TooleJohn R. Sedor

disease progressionmedicinevascular biologysystems biologygeneticsnephrotic patientsallelic variantglomerular transcriptomesgenetic epidemiology

Apol1 Genotype and Hiv Infection: 20-Year Outcomes for Ckd, Cardiovascular Disease, and Hypertension. Kidney International Reports (2024)

Katherine K. TassiopoulosKunling WuZhenzhen WuEdgar T. OvertonFrank J. PalellaChristina WyattRobert C. KalayjianLeslie A. Bruggeman

public healthhivkidney researchhyperlipidemiaautoimmune diseasesperipheral vascular diseasethrombosisepidemiologynephrologyhiv infectionvascular diseasehypertensionintensive careinfectious diseasesrenal caregenetic epidemiologyyear outcomespregnancy hypertension

Cefazolin Shifts the Kidney Microbiota to Promote a Lithogenic Environment. Nature Communications (2024)

Jose AgudeloXing ChenSromona D. MukherjeeJane K. NguyenLeslie A. BruggemanAaron W. Miller

microbiomelithogenic environmentbiochemistrykidney microbiota

Glomerular Elastic Modulus and Gene Expression Patterns Define Two Phases of Alport Nephropathy. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Joonho YoonZhenan LiuMathew AlabaLeslie A. BruggemanPaul A. JanmeyCarlos A. AranaOluwatoyosi AyenuyoIsabela MedeirosSean EddyMatthias KretzlerJoel M. HendersonViji NairAbhijit S. NaikAudrey N. ChangR. Tyler Miller

biophysicsalport nephropathynephrologyglomerular elasticitymolecular biologygene expression patternshealth sciences

Fetal High-Risk Apol1 Genotype Increases Risk for Small for Gestational Age in Term Infants Affected by Preeclampsia. Neonatology (2023)

Timur AzhibekovRazaq DurodoyeAnna K. MillerClaire L. SimpsonRobert L. DavisScott M. WilliamsLeslie A. Bruggeman

gestational agematernal-fetal medicineterm infantsgenetic predispositiongeneticsmaternal healthneonatologypediatricsgenotype-phenotype association

Local Inflammation but Not Kidney Cell Infection Associated With High Apol1 Expression in Covid-Associated Nephropathy. Kidney360 (2023)

Jane K. NguyenZhenzhen WuJose AgudeloLeal C. HerlitzAaron W. MillerLeslie A. Bruggeman

neurologymedicinenephrologylocal inflammationcovid-associated nephropathyrespiratory medicinehealth sciences

Essential Role of Wtip in Mouse Development and Maintenance of the Glomerular Filtration Barrier. AJP Renal Physiology (2022)

Sethu M. MadhavanMartha KonieczkowskiLeslie A. BruggemanMegan DeWaltJane K. NguyenJohn F. O’TooleJohn R. Sedor

physiologyanimal physiologynephrologyurologyglomerular filtration barriermouse developmentdevelopmental biology

Increased Glomerular Elasticity Corresponds to Podocyte Injury and Loss in Alport Mice. Journal of the American Society of Nephrology (2022)

R. Tyler MillerZhenan LiuJoonho YoonLeslie A. BruggemanChao XingAdwait SathePaul A. JanmeyJoel M. HendersonAudrey N. Chang

neurologyliver physiologytissue (biology)cellular physiologyregenerative medicineanimal physiologynephrologyvascular biologymammalian physiologymammalian biologytissue injuryrenal functionalport miceandrologymembrane biologybiomechanicsneurosciencecell biology

Moving Toward a Common Pathogenic Mechanism and Therapeutic Targets for Apol1 Nephropathies. American Journal of Kidney Diseases (2022)

Leslie A. BruggemanTimur AzhibekovJohn F. O’Toole

digestive diseasespharmacologypathogenesisrenal functionnephrologyurologychronic kidney diseaseadrenal diseasecommon pathogenic mechanismrenal pathophysiologymedicinal researchrenal carepathologyapathyinflammation

Viral Associations With Kidney Disease Diagnosis and Altered Kidney Metatranscriptome by Kidney Function. Kidney International (2022)

Changjin HongFelix EichingerMohamed G. AttaMichelle M. EstrellaDerek M. FineMichael J. RossChristina WyattTae Hyun HwangMatthias KretzlerJohn R. SedorJohn F. O’TooleAaron W. MillerLeslie A. Bruggeman

medicinevirus-host interactionsrenal functionnephrologykidney functionurologyvirologykidney metatranscriptome

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Leslie Bruggeman

Professor Professor of Molecular Medicine

Case Western Reserve University

Affiliations

School of Medicine

Molecular Medicine

Leslie Bruggeman is currently serving as a Molecular Medicine Professor Professor of Molecular Medicine at Case Western Reserve University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Leslie Bruggeman

Case Western Reserve University

Professor Professor of Molecular Medicine

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Analysis of Glomerular Transcriptomes From Nephrotic Patients Suggest Apol1 Risk Variants Impact Parietal Epithelial Cells. medRxiv (2024)

Agustin Gonzalez-VicenteDana C. CrawfordWilliam S. BushZhenzhen WuLeslie A. BruggemanViji NairFelix EichingerOliver WesselyMatthias KretzlerJohn F. O’TooleJohn R. Sedor

disease progressionmedicinevascular biologysystems biologygeneticsnephrotic patientsallelic variantglomerular transcriptomesgenetic epidemiology

Apol1 Genotype and Hiv Infection: 20-Year Outcomes for Ckd, Cardiovascular Disease, and Hypertension. Kidney International Reports (2024)

Katherine K. TassiopoulosKunling WuZhenzhen WuEdgar T. OvertonFrank J. PalellaChristina WyattRobert C. KalayjianLeslie A. Bruggeman

Cefazolin Shifts the Kidney Microbiota to Promote a Lithogenic Environment. Nature Communications (2024)

Jose AgudeloXing ChenSromona D. MukherjeeJane K. NguyenLeslie A. BruggemanAaron W. Miller

microbiomelithogenic environmentbiochemistrykidney microbiota

Glomerular Elastic Modulus and Gene Expression Patterns Define Two Phases of Alport Nephropathy. bioRxiv (Cold Spring Harbor Laboratory) (2024)

biophysicsalport nephropathynephrologyglomerular elasticitymolecular biologygene expression patternshealth sciences

Fetal High-Risk Apol1 Genotype Increases Risk for Small for Gestational Age in Term Infants Affected by Preeclampsia. Neonatology (2023)

Timur AzhibekovRazaq DurodoyeAnna K. MillerClaire L. SimpsonRobert L. DavisScott M. WilliamsLeslie A. Bruggeman

gestational agematernal-fetal medicineterm infantsgenetic predispositiongeneticsmaternal healthneonatologypediatricsgenotype-phenotype association

Local Inflammation but Not Kidney Cell Infection Associated With High Apol1 Expression in Covid-Associated Nephropathy. Kidney360 (2023)

Jane K. NguyenZhenzhen WuJose AgudeloLeal C. HerlitzAaron W. MillerLeslie A. Bruggeman

neurologymedicinenephrologylocal inflammationcovid-associated nephropathyrespiratory medicinehealth sciences

Essential Role of Wtip in Mouse Development and Maintenance of the Glomerular Filtration Barrier. AJP Renal Physiology (2022)

Sethu M. MadhavanMartha KonieczkowskiLeslie A. BruggemanMegan DeWaltJane K. NguyenJohn F. O’TooleJohn R. Sedor

physiologyanimal physiologynephrologyurologyglomerular filtration barriermouse developmentdevelopmental biology

Increased Glomerular Elasticity Corresponds to Podocyte Injury and Loss in Alport Mice. Journal of the American Society of Nephrology (2022)

R. Tyler MillerZhenan LiuJoonho YoonLeslie A. BruggemanChao XingAdwait SathePaul A. JanmeyJoel M. HendersonAudrey N. Chang

Moving Toward a Common Pathogenic Mechanism and Therapeutic Targets for Apol1 Nephropathies. American Journal of Kidney Diseases (2022)

Leslie A. BruggemanTimur AzhibekovJohn F. O’Toole

Viral Associations With Kidney Disease Diagnosis and Altered Kidney Metatranscriptome by Kidney Function. Kidney International (2022)

medicinevirus-host interactionsrenal functionnephrologykidney functionurologyvirologykidney metatranscriptome

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