Faculty

Institution

Unit

Venue

Brian Howell

Associate Professor

Upstate Medical University

Affiliations

Norton College of Medicine

Department Of Anesthesiology

Department Of Psychiatry And Behavioural Neuroscience

Departments Of Psychiatry And Neuroscience

Institute Of Crouse Neuroscience

Department Of Anesthesiology

Norton College Of Medicine

Brian Howell is currently serving as an Anesthesiology Associate Professor at Upstate Medical University.

Honors

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Experiences

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Education

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Brian Howell

Upstate Medical University

Associate Professor

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neuroscience cell biology molecular biology cell signaling developmental neurobiology molecular neurobiology neurons molecular cell biology developmental biology molecular and cellular biology signal transduction molecular neurodegeneration gene expression molecular neuroscience signaling pathways neurodegenerative diseases protein science cell metabolism cellular physiology cellular neurobiology neurodevelopmental disorders receptor (biochemistry) biological chemistry developmental system mammalian biology molecular psychiatry brain science molecular regulation cell regulation developmental genetics cancer biology transcription regulation metabolic regulation cortical remodeling amyloid precursor protein medicinal research molecular physiology pharmacological research genome biology diabetes research cancer cells medical genetics receptor tyrosine kinases neural science brain function neurotransmission gene function tumor suppressors structural plasticity cell interactions autism spectrum disorder hippo pathway hippo signaling protein transport intracellular trafficking drug targets drug targeting molecular basis biomolecular interactions endocytic pathway amyotrophic lateral sclerosis degenerative disease diabetes mellitus metabolic disorders neurite outgrowth receptor clustering reelin signaling reelin effects neuronal polarization dendritic golgi deployment dendritic spines tyrosine-phosphorylating enzyme sequence homology adult neurogenesis reelin pathway cell-autonomous inactivation

Notable Scholarly Works

Notable Federal Grants

Collaborators

Inhibition of Gckiii Kinases Stk25 and Mst3 Mitigates Organ Lipotoxicity and Enhances Metabolic Resilience Under Nutritional Stress. BMC Medicine (2025)

physiologymetabolic resiliencemetabolic remodelinggckiii kinases stk25metabolic regulationlipidsmolecular metabolismnutritional stressmetabolismcell metabolismbiochemistrycell biology

Whole Genome Analysis in Apoe4 Homozygotes Identifies the Dab1-Reln Pathway in Alzheimer's Disease Pathogenesis. Neurobiology of Aging (2022)

brain pathologywhole genome analysisdab1-reln pathwaymolecular biologymolecular neurodegenerationdegenerative pathologydisease pathogenesisalzheimer's diseaseneuroscience of agingneurodegenerative diseasescell biology

Antagonizing Stk25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways. Cellular and Molecular Gastroenterology and Hepatology (2021)

Yeshwant KurheMara CaputoEmmelie CansbyYing XiaSima KumariSumit Kumar AnandBrian W. HowellHanns-Ulrich MarschallMargit Mahlapuu

pro-oncogenic pathwayssignaling pathwayscancer researchsystems biologyliver cancermolecular and cellular biologyhost factorsmolecular biologyoncologyhepatologymetabolic pathwayscancer biologyhepatocellular carcinomacell biology

Maternal Ethanol Exposure Acutely Elevates Src Family Kinase Activity in the Fetal Cortex. Molecular Neurobiology (2021)

Dandan WangBrian W. HowellEric C. Olson

fetal cortexmolecular neurobiologyearly life exposuresmaternal healthdevelopmental neurobiologymaternal ethanol exposurehuman exposureneuroscience

Stk25 and Mst3 Have Overlapping Roles to Regulate Rho Gtpases During Cortical Development. Journal of Neuroscience (2021)

signaling pathwaysrho gtpasesmolecular psychiatrystructural plasticitycell signalingmolecular neurosciencemolecular neurobiologycortical developmentmolecular cell biologydevelopmental neurobiologymolecular neurodegenerationdevelopmental biologysignal transductionneurosciencecortical remodelingneuronscell biology

Depletion of Protein Kinase Stk25 Ameliorates Renal Lipotoxicity and Protects Against Diabetic Kidney Disease. JCI Insight (2020)

physiologydiabetes therapiespharmacologydiabetesrenal functionnephrologyprotein kinase stk25chronic kidney diseaserenal lipotoxicityrenal pathophysiologydiabetic medicinediabetes researchdiabetic kidney diseasecell biology

Ethanol Exposure Transiently Elevates but Persistently Inhibits Tyrosine Kinase Activity and Impairs the Growth of the Nascent Apical Dendrite. Molecular Neurobiology (2019)

Dandan WangJoshua EnckBrian W. HowellEric C. Olson

ethanol exposuredevelopmental neurobiologymolecular biologynascent apical dendritetyrosine kinase activitymolecular neurobiology

Identification of the Kinase Stk25 as an Upstream Activator of Lats Signaling. Nature Communications (2019)

Sanghee LimNicole HermanceTenny MudiantoHatim M. MustalyIan Paolo Morelos MauricioMarc A. VittoriaRyan J. QuintonBrian W. HowellHauke CornilsAmity L. ManningNeil J. Ganem

signaling pathwayscancer biologysystems biologycell signalingtumor suppressorshippo signalingmolecular cell biologyoncogenescancer cellshippo pathwaykinase stk25signal transductiontumor biologycell biology

Reelin Can Modulate Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Neurons via the Canonical Pathway. Frontiers in Cellular Neuroscience (2018)

endocrine mechanismsreproductive hormonesendocrinologybiologyolfactory ensheathing cellsmodulate migrationreproductive biologycanonical pathwaynervous systempsychoneuroendocrinologyneuroscienceneuroendocrine mechanismsneurons

Stk25 Directly Activates Lats1/2 Independent of Mst/Map4ks. bioRxiv (Cold Spring Harbor Laboratory) (2018)

Sanghee LimNicole HermanceTenny MudiantoHatim M. MustalyIan Paolo Morelos MauricioMarc A. VittoriaRyan J. QuintonBrian W. HowellHauke CornilsAmity L. ManningNeil J. Ganem

signaling pathwayscell regulationcancer biologysystems biologycell signalingmolecular cancerreceptor tyrosine kinasestumor suppressorsmolecular cell biologyhippo signalinghippo activationoncogenescancer cellshippo pathwaysignal transductiontumor biologycell biology

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Brian Howell

Associate Professor

Upstate Medical University

Affiliations

Norton College of Medicine

Department Of Anesthesiology

Department Of Psychiatry And Behavioural Neuroscience

Departments Of Psychiatry And Neuroscience

Institute Of Crouse Neuroscience

Department Of Anesthesiology

Norton College Of Medicine

Brian Howell is currently serving as an Anesthesiology Associate Professor at Upstate Medical University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Brian Howell

Upstate Medical University

Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Inhibition of Gckiii Kinases Stk25 and Mst3 Mitigates Organ Lipotoxicity and Enhances Metabolic Resilience Under Nutritional Stress. BMC Medicine (2025)

physiologymetabolic resiliencemetabolic remodelinggckiii kinases stk25metabolic regulationlipidsmolecular metabolismnutritional stressmetabolismcell metabolismbiochemistrycell biology

Whole Genome Analysis in Apoe4 Homozygotes Identifies the Dab1-Reln Pathway in Alzheimer's Disease Pathogenesis. Neurobiology of Aging (2022)

Yeshwant KurheMara CaputoEmmelie CansbyYing XiaSima KumariSumit Kumar AnandBrian W. HowellHanns-Ulrich MarschallMargit Mahlapuu

Maternal Ethanol Exposure Acutely Elevates Src Family Kinase Activity in the Fetal Cortex. Molecular Neurobiology (2021)

Dandan WangBrian W. HowellEric C. Olson

fetal cortexmolecular neurobiologyearly life exposuresmaternal healthdevelopmental neurobiologymaternal ethanol exposurehuman exposureneuroscience

Stk25 and Mst3 Have Overlapping Roles to Regulate Rho Gtpases During Cortical Development. Journal of Neuroscience (2021)

Depletion of Protein Kinase Stk25 Ameliorates Renal Lipotoxicity and Protects Against Diabetic Kidney Disease. JCI Insight (2020)

Ethanol Exposure Transiently Elevates but Persistently Inhibits Tyrosine Kinase Activity and Impairs the Growth of the Nascent Apical Dendrite. Molecular Neurobiology (2019)

Dandan WangJoshua EnckBrian W. HowellEric C. Olson

ethanol exposuredevelopmental neurobiologymolecular biologynascent apical dendritetyrosine kinase activitymolecular neurobiology

Identification of the Kinase Stk25 as an Upstream Activator of Lats Signaling. Nature Communications (2019)

Sanghee LimNicole HermanceTenny MudiantoHatim M. MustalyIan Paolo Morelos MauricioMarc A. VittoriaRyan J. QuintonBrian W. HowellHauke CornilsAmity L. ManningNeil J. Ganem

Reelin Can Modulate Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Neurons via the Canonical Pathway. Frontiers in Cellular Neuroscience (2018)

Stk25 Directly Activates Lats1/2 Independent of Mst/Map4ks. bioRxiv (Cold Spring Harbor Laboratory) (2018)

Sanghee LimNicole HermanceTenny MudiantoHatim M. MustalyIan Paolo Morelos MauricioMarc A. VittoriaRyan J. QuintonBrian W. HowellHauke CornilsAmity L. ManningNeil J. Ganem

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10 / page