Faculty

Institution

Unit

Venue

Brett Spear

University of Kentucky

Affiliations

the Graduate School

NoneBrett Spear is currently serving as a The Graduate School faculty at University of Kentucky.

Honors

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Experiences

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Education

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Brett Spear

University of Kentucky

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pharmacology genetics gene expression mammalian biology liver physiology molecular biology hepatology cell biology tumor biology membrane biology toxicology medicinal research liver cancer cancer research oncology cancer biology gene regulation transcription regulation molecular regulation molecular physiology experimental toxicology cancer treatment gene function genome biology molecular cell biology hepatocellular carcinoma molecular and cellular biology molecular cancer clinical toxicology cellular biology cellular therapy oncogenes anti-cancer agents enzyme inhibition animal biotechnology food science cellular physiology cell regulation zinc fingers applied pharmacology regulatory toxicology pharmacotherapy animal genetics apoptosis tumor targeting cancer genomics mammalian physiology peroxisome proliferators hepatic cell proliferation human nutrition nutritional sciences hepatotoxicity redox signaling food toxicology cancer genetics inhalation toxicology polychlorinated biphenyls transgenic mice mice deficient biliary cancer viral genetics cell proliferation cancer management hepatobiliary tumors hyperlipidemia cancer growth liver carcinogenesis liver development transient heterokaryons peroxisome proliferator ciprofibrate peroxisome proliferator hepatic tumor adult liver transcription factor activities retrovirus insertion hereditary persistence

Notable Scholarly Works

Notable Federal Grants

Collaborators

Elongation of Very Long Chain Fatty Acids-3 ( Elovl3 ) is Activated by Zhx2 and is a Regulator of Cell Cycle Progression. AJP Gastrointestinal and Liver Physiology (2023)

Kate Townsend CreasyHui RenJieyun JiangMartha L. PetersonBrett T. Spear

translational physiologyliver physiologybiochemistrycell cycle progressionmolecular biologycell signalingmolecular regulationphysiology

Elongation of Very Long Chain Fatty Acids-Like 3 (Elovl3) is Activated by Zhx2 and is a Regulator of Cell Cycle Progression. American Journal of Physiology- Gastrointestinal and Liver Physiology. Figshare (2023)

Kate Townsend CreasyHui RenJieyun JiangMartha L. PetersonBrett T. Spear

pharmacologycancer biologyliver physiologycell cycle progressionmolecular biologycell signalingmolecular regulationphysiology

Zinc Fingers and Homeoboxes 2 is Required for Diethylnitrosamine‐Induced Liver Tumor Formation in C57Bl/6 Mice. Hepatology Communications (2022)

Jieyun JiangCourtney TurpinGuofang (Shirley) QiuMei XuEun LeeTerry D. HindsMartha L. PetersonBrett T. Spear

hepatologypharmacologycytopathologyliver cancerliver physiologyoncologyhepatocellular carcinomabioactive metalhepatobiliary tumorstumor biologythoracic oncologydermatologycarcinogenesiscell biologymedicinal researchzinc fingersdrug metabolism

IMERS: Interactive Mentoring to Enhance Research Skills Grant‐Writing Workshops for Faculty at Minority Serving Institutions. The FASEB Journal (2021)

Melissa NickellBrett SpearDonald Frazier

higher educationeducationminority serving institutionsmentorshipinteractive mentoringeducational researchfaculty professional development

The Prorenin Receptor and Its Soluble Form Contribute to Lipid Homeostasis. American Journal of Physiology-Endocrinology and Metabolism (2021)

Eva GatineauGertrude ArthurAudrey PoupeauKellea NicholsBrett T. SpearNathan R. ShelmanGregory A. GrafRyan E. TemelFrédérique B. Yiannikouris

liver physiologybiochemistrycellular physiologyprorenin receptorlipid homeostasismembrane biologymolecular physiologyvascular biologypharmacologyreceptorsendocrine researchsecondary metabolismdyslipidemiahyperlipidemiaendocrinologyheme homeostasisclinical lipidologydrug metabolismmetabolismphysiology

A Mutation in the Gene Encoding the Transcription Factor Zinc Fingers and Homeoboxes 2 (Zhx2) is Responsible for Increased Liver Fibrosis in Balb/Cj Mice. The FASEB Journal (2020)

Courtney Paige TurpinJieyun JiangMartha L. PetersonBrett T. Spear

geneticsmembrane biologygene expressionmammalian biologyliver physiologytranscription factorsgenetic factorstranscription regulationbiliary disordermolecular biologyfibrosisdermatologyvascular biologyhematologyprotein sciencetranscription (biology)liver disease

Evolutionary Analysis of the Zinc Finger and Homeoboxes Family of Proteins Identifies Multiple Conserved Domains and a Common Early Chordate Ancestor. Genome Biology and Evolution (2020)

Alexandra N NailJeramiah J SmithMartha L PetersonBrett T Spear

conserved domainshomeoboxes familygenome biologyevolutionary analysiszinc fingerevolutionary biologymolecular evolution

Highly Homologous Mouse Cyp2A4 and Cyp2A5 Genes Are Differentially Expressed in the Liver and Both Express Long Non-Coding Antisense Rnas. Gene (2020)

Alexandra N. NailBrett T. SpearMartha L. Peterson

geneticsgenetic engineeringgene functiongene expressionmolecular geneticsrna biologygene regulationmolecular biologytumor biologymammalian biologytranscription (biology)

An Underlying Mechanism of Dual Wnt Inhibition and Ampk Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors. Journal of Medicinal Chemistry (2019)

Wen ZhangVitaliy M. SviripaLiliia M. KrilTianxin YuYanqi XieW. Brad HubbardPatrick G. SullivanXi ChenChang-Guo ZhanYang Yang-HartwichB. Mark EversBrett T. SpearRoberto GedalyDavid S. WattChunming Liu

medicinal chemistrypharmacologymitochondrial uncouplerswnt inhibitorsmedicinedrug discoveryunderlying mechanismdual wnt inhibitionampk activation

Autophagic Flux Modulation by Wnt/β-Catenin Pathway Inhibition in Hepatocellular Carcinoma. PLoS ONE (2019)

Lilia TurciosEduardo ChaconCatherine GarciaPedro EmanVirgilius CorneaJieyun JiangBrett SpearChunming LiuDavid S. WattFrancesc MartiRoberto Gedaly

hepatologypharmacologyliver canceroncologyhepatocellular carcinomaradiation oncologytumor biologyautophagic flux modulationplo biology

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Brett Spear

University of Kentucky

Affiliations

the Graduate School

NoneBrett Spear is currently serving as a The Graduate School faculty at University of Kentucky.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Brett Spear

University of Kentucky

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Elongation of Very Long Chain Fatty Acids-3 ( Elovl3 ) is Activated by Zhx2 and is a Regulator of Cell Cycle Progression. AJP Gastrointestinal and Liver Physiology (2023)

Kate Townsend CreasyHui RenJieyun JiangMartha L. PetersonBrett T. Spear

translational physiologyliver physiologybiochemistrycell cycle progressionmolecular biologycell signalingmolecular regulationphysiology

Kate Townsend CreasyHui RenJieyun JiangMartha L. PetersonBrett T. Spear

pharmacologycancer biologyliver physiologycell cycle progressionmolecular biologycell signalingmolecular regulationphysiology

Zinc Fingers and Homeoboxes 2 is Required for Diethylnitrosamine‐Induced Liver Tumor Formation in C57Bl/6 Mice. Hepatology Communications (2022)

Jieyun JiangCourtney TurpinGuofang (Shirley) QiuMei XuEun LeeTerry D. HindsMartha L. PetersonBrett T. Spear

IMERS: Interactive Mentoring to Enhance Research Skills Grant‐Writing Workshops for Faculty at Minority Serving Institutions. The FASEB Journal (2021)

Melissa NickellBrett SpearDonald Frazier

higher educationeducationminority serving institutionsmentorshipinteractive mentoringeducational researchfaculty professional development

The Prorenin Receptor and Its Soluble Form Contribute to Lipid Homeostasis. American Journal of Physiology-Endocrinology and Metabolism (2021)

Eva GatineauGertrude ArthurAudrey PoupeauKellea NicholsBrett T. SpearNathan R. ShelmanGregory A. GrafRyan E. TemelFrédérique B. Yiannikouris

A Mutation in the Gene Encoding the Transcription Factor Zinc Fingers and Homeoboxes 2 (Zhx2) is Responsible for Increased Liver Fibrosis in Balb/Cj Mice. The FASEB Journal (2020)

Courtney Paige TurpinJieyun JiangMartha L. PetersonBrett T. Spear

Evolutionary Analysis of the Zinc Finger and Homeoboxes Family of Proteins Identifies Multiple Conserved Domains and a Common Early Chordate Ancestor. Genome Biology and Evolution (2020)

Alexandra N NailJeramiah J SmithMartha L PetersonBrett T Spear

conserved domainshomeoboxes familygenome biologyevolutionary analysiszinc fingerevolutionary biologymolecular evolution

Highly Homologous Mouse Cyp2A4 and Cyp2A5 Genes Are Differentially Expressed in the Liver and Both Express Long Non-Coding Antisense Rnas. Gene (2020)

Alexandra N. NailBrett T. SpearMartha L. Peterson

geneticsgenetic engineeringgene functiongene expressionmolecular geneticsrna biologygene regulationmolecular biologytumor biologymammalian biologytranscription (biology)

An Underlying Mechanism of Dual Wnt Inhibition and Ampk Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors. Journal of Medicinal Chemistry (2019)

Wen ZhangVitaliy M. SviripaLiliia M. KrilTianxin YuYanqi XieW. Brad HubbardPatrick G. SullivanXi ChenChang-Guo ZhanYang Yang-HartwichB. Mark EversBrett T. SpearRoberto GedalyDavid S. WattChunming Liu

medicinal chemistrypharmacologymitochondrial uncouplerswnt inhibitorsmedicinedrug discoveryunderlying mechanismdual wnt inhibitionampk activation

Autophagic Flux Modulation by Wnt/β-Catenin Pathway Inhibition in Hepatocellular Carcinoma. PLoS ONE (2019)

Lilia TurciosEduardo ChaconCatherine GarciaPedro EmanVirgilius CorneaJieyun JiangBrett SpearChunming LiuDavid S. WattFrancesc MartiRoberto Gedaly

hepatologypharmacologyliver canceroncologyhepatocellular carcinomaradiation oncologytumor biologyautophagic flux modulationplo biology

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biomedical informatics

biostatistics

Max Costa

Institution

New York University

molecular biology

epigenetics

Xinxin Ding

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translational research

toxicological aspect

John Digiovanni

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Jeffrey Peters

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toxicological mechanism

James Trosko

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cancer letter

stem cell

Albert Fornace

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radiation oncology

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cellular differentiation

molecular pathology

Donna Zhang

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toxicology

reactive oxygen specie

Satdarshan Monga

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cellular basis

regeneration (biology)