Faculty

Institution

Unit

Venue

Blaise Costa

Edward Via College of Osteopathic Medicine

Affiliations

Center For One Health Research

Department Of Biomedical Affairs And Research

Department Of Biomedical Research

Department Of Community And Rural Medicine

Department Of Family Medicine, Sports Medicine, Osteopathic Manipulative Medicine

Laboratory Of Molecular Pharmacology And Toxicology

Department Of Pharmacology

Edward Via College of Osteopathic Medicine

Pharmacology

NoneBlaise Costa is currently serving as a Center For One Health Research faculty at Edward Via College of Osteopathic Medicine.

Honors

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Experiences

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Education

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Blaise Costa

Edward Via College of Osteopathic Medicine

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neuroscience pharmacology neurology receptors neuropharmacology alzheimer's disease pharmacological research molecular pharmacology pharmacotherapy experimental pharmacology medicine drug discovery mammalian biology applied pharmacology experimental medicine pain research neuropsychopharmacology neuroscience of aging osteopathic medicine receptor (biochemistry) nmda receptors cranial manipulation geriatrics ageing neuroanatomy protein science medicinal research enzyme inhibition avian biology pain medicine molecular neurodegeneration respiratory medicine inhibitory activity translational pharmacology pathway analysis surface reactivity mechanisms of action drug targets in vivo systems anesthetic pharmacology pain mechanism neuropathic pain neurochemistry cellular neurobiology brain pathology degenerative pathology neurochemical biomarkers geriatric neurology acute medicine pulmonary diseases differential regulation alzheimer disease aged rat model aged rats positive modulatory interactions permeant cations agonist efficacy subtype-specific changes reversal potential novel allosteric modulator molecular modeling study transgenic rats pilot study tipping point

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Preliminary Study on the Effect of Quantified Cranial Osteopathic Manipulation on Wild-Type and Transgenic Rat Models of Alzheimer's Disease. Journal of Alzheimer s Disease Reports (2025)

brain pathologyneuropathologydegenerative pathologyneuroscience of agingneurodegenerative diseasesalzheimer's diseaseneurochemical biomarkerspreliminary studyneurosciencemolecular neurodegenerationtransgenic rat modelsneurology

Preliminary Pharmacokinetics and in Vivo Studies Indicate Analgesic and Stress Mitigation Effects of a Novel Nmda Receptor Modulator. Journal of Pharmacology and Experimental Therapeutics (2025)

receptorspreliminary pharmacokineticsstress mitigation effectspharmacologymolecular pharmacologypain researchneuropsychopharmacologyanesthesiologyanesthetic pharmacologyneuropharmacologyvivo studiespharmacological researchpain mechanismexperimental pharmacologypain medicineapplied pharmacologypain managementneuropathic painpharmacotherapy

An Agonist Concentration Biased Nmda Receptor Modulator Produces Analgesic Activity in Experimental Animals. Journal of Pharmacology and Experimental Therapeutics (2024)

Blaise CostaNakia PhillipSeth BoehringerPatrick RafaelJennifer Davis

analgesic activityexperimental pharmacologyexperimental animalspharmacologynmda receptor modulatoragonist concentrationpain managementpain research

Effect of Quantified Cranial Osteopathic Manipulation on Wild Type and Transgenic Rat Models of Alzheimer’s Disease. bioRxiv (Cold Spring Harbor Laboratory) (2024)

De’Yana HinesHope TobeyPatrick DuganSeth BoehringerRichard HelmRamu AnandakrishnanStephen WerrePamela VandeVordBlaise M. Costa

alzheimer's diseasetransgenic rat models

Cns4 Causes Subtype‐Specific Changes in Agonist Efficacy and Reversal Potential of Permeant Cations in Nmda Receptors. Pharmacology Research & Perspectives (2023)

Seth C. BoehringerTullia V. JohnstonLina Cortez KwapiszPamela J. VandeVordBlaise M. Costa

receptorsmedicinereceptor (biochemistry)protein sciencepharmacologytranslational pharmacologymolecular pharmacologypathway analysispermeant cationsdrug discoveryneuropharmacologyagonist efficacysubtype-specific changesmedicinal researchreversal potentialpharmacological researchsurface reactivityexperimental pharmacologyapplied pharmacologysignal transductionmolecular biologypharmacotherapy

An Agonist Concentration Biased Allosteric Modulator Potentiates Nmda Induced Ion Influx in Neurons. Authorea (Authorea) (2022)

Blaise CostaLina Cortés KwapiszBrittney MehrkensDouglas BledsoeBryanna VaccaTullia JohnstonAnushri WagnerRehan RazzaqDhanasekaran ManickamBradley Klein

systems neuroscienceneurochemistryneuropharmacologycellular neurobiologycell signalingneurosciencepharmacologysignal transductionneurologyneurophysiology

Cranial Manipulation Affects Cholinergic Pathway Gene Expression in Aged Rats. Journal of Osteopathic Medicine (2022)

Ramu AnandakrishnanHope TobeySteven NguyenOsscar SandovalBradley G. KleinBlaise M. Costa

aged ratsgeriatricsneuroscienceageingcranial manipulationmammalian biologyneurologyneuroanatomyhealth sciencesosteopathic medicine

Nmda Receptor Potentiation and Severe Acute Respiratory Syndrome Treatment. (2022)

neuropharmacologypharmacological researchacute medicinenmda receptor potentiationpharmacologyrespiratory medicinecritical careexperimental medicinepulmonary diseasesneuropsychopharmacology

Differential Regulation of Stp, Ltp and Ltd by Structurally Diverse Nmda Receptor Subunit-Specific Positive Allosteric Modulators. Neuropharmacology (2021)

G FranceR VolianskisR IngramN BannisterR RothärmelMW Irvine...

receptorsmedicineneuropharmacologyneurosciencepharmacologydifferential regulation

Cranial Manipulation Affects Cholinergic Pathway Gene Expression in an Animal Model of Age-Related Cognitive Decline. Research Square (Research Square) (2020)

Ramu AnandakrishnanHope TobeySteven NguyenOsscar Gonzalez SandovalBradley G. KleinBlaise M. Costa

animal modelage-related cognitive declinecognitive scienceneuroscience of agingneurosciencecranial manipulationgeriatric neurologyneurologybrain injurycognitive neuroscience

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Blaise Costa

Edward Via College of Osteopathic Medicine

Affiliations

Center For One Health Research

Department Of Biomedical Affairs And Research

Department Of Biomedical Research

Department Of Community And Rural Medicine

Department Of Family Medicine, Sports Medicine, Osteopathic Manipulative Medicine

Laboratory Of Molecular Pharmacology And Toxicology

Department Of Pharmacology

Edward Via College of Osteopathic Medicine

Pharmacology

NoneBlaise Costa is currently serving as a Center For One Health Research faculty at Edward Via College of Osteopathic Medicine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Blaise Costa

Edward Via College of Osteopathic Medicine

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Preliminary Study on the Effect of Quantified Cranial Osteopathic Manipulation on Wild-Type and Transgenic Rat Models of Alzheimer's Disease. Journal of Alzheimer s Disease Reports (2025)

Preliminary Pharmacokinetics and in Vivo Studies Indicate Analgesic and Stress Mitigation Effects of a Novel Nmda Receptor Modulator. Journal of Pharmacology and Experimental Therapeutics (2025)

An Agonist Concentration Biased Nmda Receptor Modulator Produces Analgesic Activity in Experimental Animals. Journal of Pharmacology and Experimental Therapeutics (2024)

Blaise CostaNakia PhillipSeth BoehringerPatrick RafaelJennifer Davis

analgesic activityexperimental pharmacologyexperimental animalspharmacologynmda receptor modulatoragonist concentrationpain managementpain research

Effect of Quantified Cranial Osteopathic Manipulation on Wild Type and Transgenic Rat Models of Alzheimer’s Disease. bioRxiv (Cold Spring Harbor Laboratory) (2024)

De’Yana HinesHope TobeyPatrick DuganSeth BoehringerRichard HelmRamu AnandakrishnanStephen WerrePamela VandeVordBlaise M. Costa

alzheimer's diseasetransgenic rat models

Cns4 Causes Subtype‐Specific Changes in Agonist Efficacy and Reversal Potential of Permeant Cations in Nmda Receptors. Pharmacology Research & Perspectives (2023)

Seth C. BoehringerTullia V. JohnstonLina Cortez KwapiszPamela J. VandeVordBlaise M. Costa

An Agonist Concentration Biased Allosteric Modulator Potentiates Nmda Induced Ion Influx in Neurons. Authorea (Authorea) (2022)

Blaise CostaLina Cortés KwapiszBrittney MehrkensDouglas BledsoeBryanna VaccaTullia JohnstonAnushri WagnerRehan RazzaqDhanasekaran ManickamBradley Klein

systems neuroscienceneurochemistryneuropharmacologycellular neurobiologycell signalingneurosciencepharmacologysignal transductionneurologyneurophysiology

Cranial Manipulation Affects Cholinergic Pathway Gene Expression in Aged Rats. Journal of Osteopathic Medicine (2022)

Ramu AnandakrishnanHope TobeySteven NguyenOsscar SandovalBradley G. KleinBlaise M. Costa

aged ratsgeriatricsneuroscienceageingcranial manipulationmammalian biologyneurologyneuroanatomyhealth sciencesosteopathic medicine

Nmda Receptor Potentiation and Severe Acute Respiratory Syndrome Treatment. (2022)

neuropharmacologypharmacological researchacute medicinenmda receptor potentiationpharmacologyrespiratory medicinecritical careexperimental medicinepulmonary diseasesneuropsychopharmacology

Differential Regulation of Stp, Ltp and Ltd by Structurally Diverse Nmda Receptor Subunit-Specific Positive Allosteric Modulators. Neuropharmacology (2021)

G FranceR VolianskisR IngramN BannisterR RothärmelMW Irvine...

receptorsmedicineneuropharmacologyneurosciencepharmacologydifferential regulation

Cranial Manipulation Affects Cholinergic Pathway Gene Expression in an Animal Model of Age-Related Cognitive Decline. Research Square (Research Square) (2020)

Ramu AnandakrishnanHope TobeySteven NguyenOsscar Gonzalez SandovalBradley G. KleinBlaise M. Costa

animal modelage-related cognitive declinecognitive scienceneuroscience of agingneurosciencecranial manipulationgeriatric neurologyneurologybrain injurycognitive neuroscience

1
2
10 / page