Faculty

Institution

Unit

Venue

Blaine Bartholomew

Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Epigenetics And Molecular Carcinogenesis

MD Anderson UTHealth Houston Graduate School

The University of Texas MD Anderson Cancer Center

Blaine Bartholomew is currently serving as an Epigenetics And Molecular Carcinogenesis Professor at The University of Texas Md Anderson Cancer Center.

Honors

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Experiences

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Education

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Blaine Bartholomew

The University of Texas MD Anderson Cancer Center

Professor

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molecular biology molecular cell biology chromatin chromatin remodeling nucleic acids nuclear organization cell biology genetics structural molecular biology epigenetics genome biology transcription (biology) structural biology gene expression biomolecular structure transcription regulation molecular and cellular biology transcription factors gene regulation systems biology protein science nucleic acid chemistry yeast rna biology dna repair biological chemistry molecular regulation epigenetic changes extranucleosomal dna chromosome biology multi-protein assembly cellular biochemistry cellular biology gene regulatory networks epigenomics genomic mechanisms atp-dependent chromatin remodelers chromatin landscape proteome research oncogenes developmental system chromosomal rearrangements oligonucleotides molecular biological method dna analysis mutagenesis protein assembly molecular complexes rna processing rna polymerase iii concerted action rna polymerase ii nucleosome dynamics cell lineage priming nucleosome movement molecular structure nuclear science molecular diagnostics developmental cell heredity gene transfer hla typing nucleation functional modification protein biosynthesis integrative biology purification method single molecule biophysics cytogenetics dna translocation asymmetric model binding site linker histones dna gyres multi-base-pair entry steps iswi remodelers

Notable Scholarly Works

Notable Federal Grants

Collaborators

Dna Bendability Inside the Nucleosome Regulates Ino80’S Nucleosome Positioning. Molecular Cell (2025)

biophysicsnucleic acid chemistrymolecular cell biologydna bendabilitymolecular biologystructural molecular biologychromatin remodelingchromatinbiomolecular structurenuclear organizationnucleic acids

Conformational Switching of Arp5 Subunit Regulates Ino80 Chromatin Remodeling. Nucleic Acids Research (2024)

molecular regulationmolecular cell biologystructural molecular biologymolecular biologychromatin remodelingchromatinnuclear organizationprotein scienceconformational switchingcell biology

Enhancer Switching in Cell Lineage Priming is Linked to Erna, Brg1’S At-Hook, and Swi/Snf Recruitment. Molecular Cell (2024)

Dhurjhoti SahaSrinivas AnimireddyJunwoo LeeAnna ThommenMcKenzie M. MurvinYue LuJ. Mauro CalabreseBlaine Bartholomew

geneticscell lineage primingmolecular cell biologymolecular biologydevelopmental biologytumor biology

Ino80'S Unique Mechanism for Mobilizing Nucleosomes Determines Its Dna-Shape Specificity. SSRN Electronic Journal (2024)

biophysicsunique mechanismnucleic acid chemistrybiomolecular structuremolecular cell biologymolecular biologystructural molecular biologychromatin remodelingchromatinstructural biologynuclear organizationnucleic acids

Introductory Analysis and Validation of Cut #38;Run Sequencing Data. Journal of Visualized Experiments (2024)

genomicstranscriptomegenome biologylong-read sequencingnext-generation sequencinghigh throughput sequencinggeneticsintroductory analysisbioinformatics

The Swi/Snf Atp-Dependent Chromatin Remodeling Complex in Cell Lineage Priming and Early Development. Biochemical Society Transactions (2024)

genome biologygene regulationtranscription regulationdevelopmental biologycell lineage primingmolecular cell biologyswi/snf atp-dependent chromatinmolecular biologychromatin remodelingepigeneticschromatinearly development

New Insights Into the Mechanism and Dna-Sequence Specificity of Ino80 Chromatin Remodeling. Research Square (2023)

Blaine BartholomewShagun ShuklaMzwanele NguboSomnath PaulJim PersingerSandipan Brahma

molecular biologychromatin remodelingchromatindna-sequence specificitynuclear organizationbiochemistry

Super-Enhancer Switching in Early Mammalian Development Involves Erna Mediated Swi/Snf Recruitment. SSRN Electronic Journal (2023)

Dhurjhoti SahaSrinivas AnimireddyJunwoo LeeAnna ThommenMcKenzie MurvinYue LuMauro CalabreseBlaine Bartholomew

early mammalian developmentsuper-enhancer switchingdevelopmental biology

The At-Hook is an Evolutionarily Conserved Auto-Regulatory Domain of Swi/Snf Required for Cell Lineage Priming. Nature Communications (2023)

genome biologydevelopmental systemauto-regulatory domaingene expressiongene regulatory networkscell signalingmolecular and cellular biologygeneticstranscription factorsmolecular cell biologycell lineagegene functionlineage plasticitydevelopmental biologysignal transductioncellular differentiationgene regulationcell biology

An Rna Binding Module of Swi/Snf is Required for Activation of Cell-Type Specific Enhancers and Super-Enhancers in Early Development. bioRxiv (Cold Spring Harbor Laboratory) (2022)

developmental systemgene expressiontranscription regulationfunctional genomicsrna processingtranscription (biology)developmental celltranscription factorsmolecular cell biologygene functioncell-type specific enhancersmolecular biologyrna binding moduledevelopmental biologyrna biologyearly developmentgene regulationcell biology

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Blaine Bartholomew

Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Epigenetics And Molecular Carcinogenesis

MD Anderson UTHealth Houston Graduate School

The University of Texas MD Anderson Cancer Center

Blaine Bartholomew is currently serving as an Epigenetics And Molecular Carcinogenesis Professor at The University of Texas Md Anderson Cancer Center.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Blaine Bartholomew

The University of Texas MD Anderson Cancer Center

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Dna Bendability Inside the Nucleosome Regulates Ino80’S Nucleosome Positioning. Molecular Cell (2025)

biophysicsnucleic acid chemistrymolecular cell biologydna bendabilitymolecular biologystructural molecular biologychromatin remodelingchromatinbiomolecular structurenuclear organizationnucleic acids

Conformational Switching of Arp5 Subunit Regulates Ino80 Chromatin Remodeling. Nucleic Acids Research (2024)

molecular regulationmolecular cell biologystructural molecular biologymolecular biologychromatin remodelingchromatinnuclear organizationprotein scienceconformational switchingcell biology

Enhancer Switching in Cell Lineage Priming is Linked to Erna, Brg1’S At-Hook, and Swi/Snf Recruitment. Molecular Cell (2024)

Dhurjhoti SahaSrinivas AnimireddyJunwoo LeeAnna ThommenMcKenzie M. MurvinYue LuJ. Mauro CalabreseBlaine Bartholomew

geneticscell lineage primingmolecular cell biologymolecular biologydevelopmental biologytumor biology

Ino80'S Unique Mechanism for Mobilizing Nucleosomes Determines Its Dna-Shape Specificity. SSRN Electronic Journal (2024)

Introductory Analysis and Validation of Cut #38;Run Sequencing Data. Journal of Visualized Experiments (2024)

genomicstranscriptomegenome biologylong-read sequencingnext-generation sequencinghigh throughput sequencinggeneticsintroductory analysisbioinformatics

The Swi/Snf Atp-Dependent Chromatin Remodeling Complex in Cell Lineage Priming and Early Development. Biochemical Society Transactions (2024)

New Insights Into the Mechanism and Dna-Sequence Specificity of Ino80 Chromatin Remodeling. Research Square (2023)

Blaine BartholomewShagun ShuklaMzwanele NguboSomnath PaulJim PersingerSandipan Brahma

molecular biologychromatin remodelingchromatindna-sequence specificitynuclear organizationbiochemistry

Super-Enhancer Switching in Early Mammalian Development Involves Erna Mediated Swi/Snf Recruitment. SSRN Electronic Journal (2023)

Dhurjhoti SahaSrinivas AnimireddyJunwoo LeeAnna ThommenMcKenzie MurvinYue LuMauro CalabreseBlaine Bartholomew

early mammalian developmentsuper-enhancer switchingdevelopmental biology

The At-Hook is an Evolutionarily Conserved Auto-Regulatory Domain of Swi/Snf Required for Cell Lineage Priming. Nature Communications (2023)

An Rna Binding Module of Swi/Snf is Required for Activation of Cell-Type Specific Enhancers and Super-Enhancers in Early Development. bioRxiv (Cold Spring Harbor Laboratory) (2022)

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