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Aron S. Buchman

Rush University

Affiliations

Rush Medical College

Center Of Rush Alzheimer'S Disease

News & Events

Rush University

Aron S. Buchman is a Senior Professor at Rush University. His research focuses on the neuroscience of aging, specifically the clinical and neuropathologic basis of Alzheimer’s disease, dementia, and cognitive impairment in older adults. His recent work employs wearable sensors and self-supervised learning to assess daily-living gait and heart rate, linking reduced physiologic complexity to faster cognitive decline. He also investigates structural variants and TDP-43 splicing dysregulation in neurodegeneration, alongside sleep and pericyte biology, advancing the understanding of age-related neuropathologic traits.

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Aron S. Buchman

Rush University

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neurology neuroscience neuroscience of aging geriatrics cognitive impairment neurodegenerative diseases ageing alzheimer's disease dementia older adults health sciences rehabilitation experimental gerontology aging-associated diseases movement disorders neurorehabilitation parkinson's disease molecular neurodegeneration geriatric neurology later adulthood healthy aging human movement cognitive decline physical aging active ageing gait analysis physiological measurements frailty geriatric medicine brain pathology aging cell social gerontology older persons community-dwelling older adults mobility neuropsychological rehabilitation vascular cognitive disorder motor function cerebral blood flow degenerative disease sleep disorders vascular dementia brain function motor disorders elderly care biogerontology brain health applied physiology movement analysis stroke rehabilitation population aging sarcopenia cohort studies genome-wide association studies aging process community-dwelling older persons old age cerebrovascular disease incident disability rush memory sleep fragmentation applied cognitive psychology physical medicine incident alzheimer supportive care musculoskeletal disorders clinical gerontology neurological disorders cognitive rehabilitation physical activity epidemiology mild cognitive impairment alzheimer disease motor decline muscle function community-based older persons physical frailty

Notable Scholarly Works

Notable Federal Grants

Collaborators

Continuous Assessment of Daily-Living Gait Using Self-Supervised Learning of Wrist-Worn Accelerometer Data. npj Digital Medicine (2026)

continuous assessmenthealth monitoringaccelerometersphysical medicinegait analysiswearable technologyhuman movementwrist-worn accelerometer dataphysical activitykinesiologyassistive technologyphysiological measurementsmovement analysisself-supervised learningrehabilitation

Arteriolosclerosis in Cns Tissues Outside the Cerebrum and Late-Life Motor Impairment. Stroke (2025)

late-life motor impairmentneurologyblood vesselsneurosciencecerebral blood flowneuropathologybrain circulationneuroradiologycns tissuesneurovascular diseasesarterial diseasecentral nervous system

Cell-Type-Specific Transcriptomic-Wide Association Studies Detected 91 Independent Risk Genes for Alzheimer’s Disease Dementia. medRxiv (2025)

neurologyalzheimer's diseaseneurogeneticsmolecular neurodegenerationgenome biologyneurodegenerative diseasescognitive impairmentaging-associated diseasesmolecular diagnosticsgenome-wide association studiesdisease dementiadementiavascular dementiaindependent risk genesgenetics

Characterizing Post-Mortem Brain Molecular Taxonomy of Cognitive Resilience and Translating It to Living Humans. bioRxiv (Cold Spring Harbor Laboratory) (2025)

neurologyneuroscience of agingbiological psychiatrycognitive neuroscienceneuroscienceneurodegenerative diseaseshuman braincognitive impairmentneurobiological factorsbrain pathologycognitive resilienceliving humansneuropsychologybrain function

Cognitive Aspects of the Motor Planning Stage of Gait: Effects of Aging and Parkinson’s Disease. Innovation in Aging (2025)

motor planning stageneuroscience of aginggait analysishuman movementmotor controlparkinson's diseaseneurosciencecognitive impairmentmovement disorderspathological gaitmovement analysiscognitive aspectsparkinson ’neurorehabilitationrehabilitation

Cognitive Decline in Older Adults With Type 2 Diabetes: Unraveling Site-Specific Glycoproteomic Alterations. PLoS ONE (2025)

type 2neurologyneuroscience of agingcognitive declinediabetes mellitusneurosciencediabetes researchcognitive impairmentaging-associated diseasesolder adultshealth sciencesdiabetes

Combining 24-Hour Continuous Monitoring of Time-Locked Heart Rate, Physical Activity and Gait in Older Adults: Preliminary Findings. Sensors (2025)

health monitoringgait analysishuman movement24-hour continuous monitoringphysical activitypathological gaitphysiological measurementsmovement analysisgeriatricsapplied physiologyhealth sciencesrehabilitationtime-locked heart rate

Genetic Predisposition to Hand Grip Weakness Predicts Cognitive Decline. SSRN Electronic Journal (2025)

neurogeneticsgenetic predispositionneurodevelopmental disordersmovement disordersbehavioural geneticscognitive impairmentmotor skillscognitive science

Identifying Motor Resilience Proteins Associated With Motor Decline in Older Adults. The Journals of Gerontology Series A (2025)

neurologyneuroscience of agingmolecular neurodegenerationageingneurodegenerative diseasesmovement disorderskinesiologyaging-associated diseasesmotor disordersmotor declinephysical agingolder adultsmusculoskeletal disordersneurorehabilitationrehabilitation

Integrating Spatial Transcriptomics and Snrna-Seq Data Enhances Differential Gene Expression Analysis Results of Ad-Related Phenotypes. Human Genetics and Genomics Advances (2025)

spatial transcriptomicsgene expression profilingfunctional genomicsgenomicsgenome biologyad-related phenotypesmolecular cell biologytranscription (biology)spatial omicssystems biologytranscriptomegene expressiontranscriptomics technologybioinformaticsgenetics

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Aron S. Buchman

Rush University

Affiliations

Rush Medical College

Center Of Rush Alzheimer'S Disease

News & Events

Rush University

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Aron S. Buchman

Rush University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Continuous Assessment of Daily-Living Gait Using Self-Supervised Learning of Wrist-Worn Accelerometer Data. npj Digital Medicine (2026)

Arteriolosclerosis in Cns Tissues Outside the Cerebrum and Late-Life Motor Impairment. Stroke (2025)

late-life motor impairmentneurologyblood vesselsneurosciencecerebral blood flowneuropathologybrain circulationneuroradiologycns tissuesneurovascular diseasesarterial diseasecentral nervous system

Cell-Type-Specific Transcriptomic-Wide Association Studies Detected 91 Independent Risk Genes for Alzheimer’s Disease Dementia. medRxiv (2025)

Characterizing Post-Mortem Brain Molecular Taxonomy of Cognitive Resilience and Translating It to Living Humans. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Cognitive Aspects of the Motor Planning Stage of Gait: Effects of Aging and Parkinson’s Disease. Innovation in Aging (2025)

Cognitive Decline in Older Adults With Type 2 Diabetes: Unraveling Site-Specific Glycoproteomic Alterations. PLoS ONE (2025)

type 2neurologyneuroscience of agingcognitive declinediabetes mellitusneurosciencediabetes researchcognitive impairmentaging-associated diseasesolder adultshealth sciencesdiabetes

Combining 24-Hour Continuous Monitoring of Time-Locked Heart Rate, Physical Activity and Gait in Older Adults: Preliminary Findings. Sensors (2025)

Genetic Predisposition to Hand Grip Weakness Predicts Cognitive Decline. SSRN Electronic Journal (2025)

neurogeneticsgenetic predispositionneurodevelopmental disordersmovement disordersbehavioural geneticscognitive impairmentmotor skillscognitive science

Identifying Motor Resilience Proteins Associated With Motor Decline in Older Adults. The Journals of Gerontology Series A (2025)

Integrating Spatial Transcriptomics and Snrna-Seq Data Enhances Differential Gene Expression Analysis Results of Ad-Related Phenotypes. Human Genetics and Genomics Advances (2025)

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