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Ann Jones Hessell

Oregon Health & Science University

Affiliations

Division Of Pathobiology And Immunology

Ann Jones Hessell is a Senior Professor at Oregon Health & Science University, specializing in immunology, virology, and infectious diseases. Her research focuses on HIV vaccine development, monoclonal antibody therapies for viral pathogens, and immune responses in nonhuman primate models. Recent breakthroughs include engineered HIV deletions for conditional replication control, aerosol-delivered SARS-CoV-2 monoclonal antibodies limiting viral replication, and investigations into complement-mediated immunity differences across species. Her work also addresses pediatric viral disease prevention through monoclonal antibodies and HIV envelope trimer vaccine enhancement via adenosine deaminase-1. She has published extensively in high-impact venues including Science, Nature Communications, and JCI Insight, contributing significantly to global health and antiviral research.

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Ann Jones Hessell

Oregon Health & Science University

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immunology hiv virology infectious diseases medical virology vaccines immune responses antiviral research virus research vaccination antibody engineering general virology immunity (medicine) viral pathogenesis antiviral responses virus-host interactions antiviral therapy medicinal research infection control human retrovirus clinical immunology medicine pharmacology clinical microbiology mammalian biology viral genetics vaccine development immunotherapy humoral response rhesus macaques viral evolution antibody screening vaccine research viral structural protein innate immune system adaptive immune system molecular virology viral persistence molecular immunology neurovirology diagnostic virology viral replication primary immunodeficiencies clinical infectious disease viral diagnostics host response primatology shiv challenge preventive medicine peptides virus structure laboratory immunology vaccine targets synthetic chemistry antiviral drug development membrane-proximal external region hiv envelope biological evaluation nonhuman primates structural molecular biology nature cellular therapy tropical medicine sexual health venereology herbal medicine antibody protection complement binding fc receptor structural definition conserved neutralization epitope human survivor vaginal challenge complete neutralization serum levels low-titer antibody protection

Notable Scholarly Works

Notable Federal Grants

Collaborators

Monoclonal Antibodies for Pediatric Viral Disease Prevention and Treatment. PEDIATRICS (2025)

Zeynep BahadirPriyanka NarayanRachael WoltersSallie R. PermarGenevieve FoudaAnn J. HessellNancy L. Haigwood

pediatricsmonoclonal antibodies

Engineered Deletions of Hiv Replicate Conditionally to Reduce Disease in Nonhuman Primates. Science (2024)

Fathima N. Nagoor PitchaiElizabeth J. TannerNeha KhetanGustavo VasenClara LevrelArjun J. KumarShilpi PandeyTracy OrdonezPhilip BarnetteDavid SpencerSeung-Yong JungJoshua GlazierCassandra ThompsonAlicia Harvey-VeraHye-In SonHye-In SonSteffanie A. StrathdeeLeo HolguinRyan UrakJohn BurnettWilliam BurgessKathleen Busman-SahayJacob D. EstesAnn HessellChristine M. FennesseyBrandon F. KeeleNancy L. HaigwoodLeor S. Weinberger

antiviral drug developmentepidemiologyvaccineshivnonhuman primatesclinical microbiologyvaccinationgeneral virologygene expressioninfection controlpublic healthvirologyengineered deletionsmedicinal researchmicrobiologyviral geneticssynthetic virologyhiv replicateantiviral researchin-situ conversionmolecular virology

Hiv-1 Interaction With an O-Glycan-Specific Bacterial Lectin Enhances Virus Infectivity and Resistance to Neutralizing Antibodies. iScience (2024)

Daniel W. HeindelDania M. Figueroa AcostaMarisa GoffClauvis Kunkeng YengoMuzafar JanXiaomei LiuXiao-Hong WangMariya I. PetrovaMo ZhangManish SagarPhillip BarnetteShilpi PandeyAnn J. HessellKun-Wei ChanXiang-Peng KongBenjamin K. ChenLara K. MahalBarbara A. BensingCatarina E. Hioe

clinical microbiologyviral pathogenesisinfectious diseasesvirologyvirus-host interactionsantiviral responsesimmunologyhivviral dynamicsglobal healthdrug resistanceimmune responsesneurovirologyantiviral researchantiviral therapymedical virologygeneral virologyinfection control

Immune Perturbation Following Shiv Infection is Greater in Newborn Macaques Than in Infants. JCI Insight (2024)

newborn macaquesinfectious diseasesshiv infectionpathogenesisimmunologymaternal immunizationimmune perturbationpathogensinfectious diseases (medical specialty)immunity (medicine)communicable diseasesviral persistencemedical virologyinfection control

Sex- and Species-Associated Differences in Complement-Mediated Immunity in Humans and Rhesus Macaques. mBio (2024)

rhesus macaquesinfectious diseasesspecies-associated differencesimmunologyhost responsecomplement-mediated immunityimmune responsesimmunity (medicine)host geneticsprimatologyhumoral responsemammalian biologyinnate immune systemreproductive immunology

The Molecular Immune Modulator Adenosine Deaminase-1 Enhances Hiv Specific Humoral and Cellular Responses to a Native-Like Hiv Envelope Trimer Dna Vaccine. Research Square (2024)

Michele A. KutzlerGina CusimanoDavid JoynerEmily KonopkaRoshell MuirPhilip BarnetteMelanie GuderianIván del Moral-SánchezRonald DerkingTom BijlJonne SnitselaarPhotis RotsidesKyra WoloszczukMatthew BellGabriela CanzianiIrwin ChaikenAnn HessellYannic BartschRogier SandersElias Haddad

molecular immunologyvaccinesvaccine developmentvaccinationimmunologyhivmedicinal researchglobal healthhealth sciences

Aerosol Delivery of Sars-Cov-2 Human Monoclonal Antibodies in Macaques Limits Viral Replication and Lung Pathology. Nature Communications (2023)

Daniel N. StreblowAlec J. HirschJeffrey J. StantonAnne D. LewisLois ColginAnn J. HessellCraig N. KreklywichJessica L. SmithWilliam F. SuttonDavid ChauvinJennifer WooBenjamin N. BimberCierra N. LeBlancSonia N. AcharyaBrian J. O’RoakHarjinder SardarMohammad M. SajadiZahra R. TehraniMark R. WalterLuis Martinez-SobridoJames J. KobieRachel J. ReaderKatherine J. OlstadTheodore R. HobbsErica Ollmann SaphireSharon L. SchendelRobert H. CarnahanJonas KnochLuis M. BrancoJames E. CroweKoen K. A. Van RompayPhillip LovalentiNone Vu TruongDonald N. ForthalNancy L. Haigwood

aerosol transportaerosol deliveryinfectious diseasesvirologyviral replicationlung pathologyimmunologyaerosol sciencerespiratory medicinesars-cov-2covid-19

Complement Contributes to Antibody-Mediated Protection Against Repeated Shiv Challenge. Proceedings of the National Academy of Sciences (2023)

shiv challengeimmunologyantiviral researchimmune responsesimmunity (medicine)humoral responsemedical virology

CORRIGENDUM: Vaccination With Immune Complexes Modulates the Elicitation of Functional Antibodies Against Hiv-1. Frontiers in Immunology (2023)

Catarina E. HioeXiaomei LiuAndrew N. BaninDaniel W. HeindelJe´romine KlinglerPriyanka G. RaoChristina C. LuoXunqing JiangShilpi PandeyTracy OrdonezPhilip BarnetteMaxim TotrovJiang ZhuArthur Na´dasSusan Zolla-PaznerChitra UpadhyayXiaoying ShenXiang-Peng KongAnn J. Hessell

public healthfunctional antibodiesimmune complexesvirologyhivimmunologyvaccinationglobal health

Evidence for the Role of a Second Fc-Binding Receptor in Placental Igg Transfer in Nonhuman Primates. mBio (2023)

Yvonne J. RosenbergTracy OrdonezUrjeet S. KhanwalkarPhilip BarnetteShilpi PandeyIara M. BackesClaire E. OteroBenjamin S. GoldbergAndrew R. CrowleyDavid A. LeibMariya B. ShapiroXiaoming JiangLori A. UrbanJonathan LeesAnn J. HessellSallie PermarNancy L. HaigwoodMargaret E. Ackerman

animal scienceplacental igg transfernonhuman primatesneurosciencemembrane biologyprimatologymammalian biology

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Ann Jones Hessell

Oregon Health & Science University

Affiliations

Division Of Pathobiology And Immunology

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Ann Jones Hessell

Oregon Health & Science University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Monoclonal Antibodies for Pediatric Viral Disease Prevention and Treatment. PEDIATRICS (2025)

Zeynep BahadirPriyanka NarayanRachael WoltersSallie R. PermarGenevieve FoudaAnn J. HessellNancy L. Haigwood

pediatricsmonoclonal antibodies

Engineered Deletions of Hiv Replicate Conditionally to Reduce Disease in Nonhuman Primates. Science (2024)

Hiv-1 Interaction With an O-Glycan-Specific Bacterial Lectin Enhances Virus Infectivity and Resistance to Neutralizing Antibodies. iScience (2024)

Immune Perturbation Following Shiv Infection is Greater in Newborn Macaques Than in Infants. JCI Insight (2024)

Sex- and Species-Associated Differences in Complement-Mediated Immunity in Humans and Rhesus Macaques. mBio (2024)

The Molecular Immune Modulator Adenosine Deaminase-1 Enhances Hiv Specific Humoral and Cellular Responses to a Native-Like Hiv Envelope Trimer Dna Vaccine. Research Square (2024)

molecular immunologyvaccinesvaccine developmentvaccinationimmunologyhivmedicinal researchglobal healthhealth sciences

Aerosol Delivery of Sars-Cov-2 Human Monoclonal Antibodies in Macaques Limits Viral Replication and Lung Pathology. Nature Communications (2023)

aerosol transportaerosol deliveryinfectious diseasesvirologyviral replicationlung pathologyimmunologyaerosol sciencerespiratory medicinesars-cov-2covid-19

Complement Contributes to Antibody-Mediated Protection Against Repeated Shiv Challenge. Proceedings of the National Academy of Sciences (2023)

shiv challengeimmunologyantiviral researchimmune responsesimmunity (medicine)humoral responsemedical virology

CORRIGENDUM: Vaccination With Immune Complexes Modulates the Elicitation of Functional Antibodies Against Hiv-1. Frontiers in Immunology (2023)

public healthfunctional antibodiesimmune complexesvirologyhivimmunologyvaccinationglobal health

Evidence for the Role of a Second Fc-Binding Receptor in Placental Igg Transfer in Nonhuman Primates. mBio (2023)

animal scienceplacental igg transfernonhuman primatesneurosciencemembrane biologyprimatologymammalian biology

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