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Angelo Taglialatela

Associate Research Scientist in the Department of Genetics and Development

Columbia University

Angelo Taglialatela is an Associate Research Scientist in the Department of Genetics and Development at Columbia University, where he also holds an appointment at the Irving Medical Center. His research focuses on DNA repair mechanisms, replication stress, and genome stability, with particular emphasis on homology-directed repair, stalled fork protection, and the roles of BRCA1, BARD1, and SMARCAL1 in tumor suppression and immune evasion. He has made significant contributions to CRISPR-based functional screens, including base editing approaches to interrogate DNA damage response variants, and has investigated extrachromosomal telomere DNA generation in ALT cancers. His recent work has explored how replication stress impairs chromosome segregation in human embryos and how SMARCAL1 regulates innate immune signaling and PD-L1 expression. His findings have been published in Cell, Nature Communications, Molecular Cell, and Nucleic Acids Research, among other leading journals.

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Angelo Taglialatela

Columbia University

Associate Research Scientist in the Department of Genetics and Development

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genetics molecular biology cell biology dna repair molecular cell biology cancer research gene expression tumor biology cancer genetics genome biology cancer biology epigenetics molecular cancer cancer cells cancer genomics genome instability immunology replication genomics carcinogenesis nucleic acids homologous recombination enzyme inhibition oncogenes cell research protein science vascular biology leukemia crispr epigenetic changes gene editing bioprospecting fork protection dna synthesis biomedical imaging cancer imaging cancer letter cancer discovery cell metabolism mutagenesis cell regulation innate immune system tumor suppressors multimodal transport biomedical modeling tissue imaging rna biology cytogenetics epigenomics chromatin remodeling cell cycle computational genomics chromosomal rearrangements reproductive physiology embryonic development chromosome biology human reproduction cancer treatment novel therapies tumor targeting cancer management key site multi-omics studies replication fork stability base editing screens functional interrogation replication fork slowing mutagenic repair primpol-dependent ssdna gaps crispr-mediated homology-directed repair dual regulator tumor immune evasion innate immune brct domains homology-directed repair dna damage

Notable Scholarly Works

Notable Federal Grants

Collaborators

Endogenous Sources of Abasic Sites and Implications for Dna Replication: Mechanisms of Fork Stalling and Recovery. Annual Review of Biochemistry (2026)

nucleic acid chemistrymolecular cell biologybiochemistrynucleic acidsmolecular biologygenome instabilitydna replicationenzymes

Author Correction: Mapping Multimodal Phenotypes to Perturbations in Cells and Tissue With Crisprmap. Nature Biotechnology (2025)

Jiacheng GuAbhishek IyerBen WesleyAngelo TaglialatelaGiuseppe LeuzziSho HangaiAubrianna DeckerRuoyu GuNaomi KlicksteinYuanlong ShuaiKristina JankovicLucy Parker-BurnsYinuo JinJia Yi ZhangJustin HongXiang NiuJonathon A. CostaMikael G. PezetJacqueline ChouCao ‘Claire’ ChenMargaret PaivaHans-Willem SnoeckDan A. LandauElham AziziEdmond M. ChanAlberto CicciaJellert T. Gaublomme

functional genomicsmulti-omics studiessynthetic biologygenome editingcellular differentiationkey sitemolecular biologybiomolecular engineeringcellular therapycell researchbiotechnologybioprospectingcell biologygene editingmapping multimodalauthor correction

Distinct Mechanisms Underlying Extrachromosomal Telomere Dna Generation in Alt Cancers. Nucleic Acids Research (2025)

geneticsmolecular cancerdna repaircancer researchchromosomal rearrangementscancer genomicsdna generationradiation oncologygenome instabilitygenome biologycancer geneticscarcinogenesisepigenetics

Abstract B023: Smarcal1 is a Novel Candidate Therapeutic Target for Alt-Positive Osteosarcoma. Cancer Research (2024)

Angelo TaglialatelaXiao ChenZahra Fatema KhanFilemon Dela CruzDua ShiviDillon OswaldAzeroglu BenuraEros Lazzerini DenchiMin JaewonAndrew L. KungAlberto Ciccia

tumor targetingclinical researchcancer cellscancer biologycancer researchdermatologypharmacologycancer treatmentoncologyalt-positive osteosarcomacellular therapycancer carecancer managementcancer immunotherapyhealth sciencesleukemiamedicinal researchnovel therapiestherapeutic targets

Abstract Pr010: Understanding Extrachromosomal Telomere Generation in Alt Cancers. Cancer Research (2024)

Junyeop LeeJina LeeEric J. SohnAngelo TaglialatelaRoderick J. O’SullivanAlberto CicciaJaewon Min

cancer biologyhealth sciencescancer researchoncologycancer genomicsradiation oncologyalt cancerscancer geneticstumor biologyclinical researchdermatologymedicinal researchvascular biology

Brca1 and 53Bp1 Regulate Reprogramming Efficiency by Mediating Dna Repair Pathway Choice at Replication-Associated Double-Strand Breaks. Cell Reports (2024)

Daniela GeorgievaNing WangAngelo TaglialatelaStepan JerabekColleen R. ReczekPei Xin LimJulie SungQian DuMichiko HoriguchiMaria JasinAlberto CicciaRichard BaerDieter Egli

geneticsmolecular cell biologycancer cellsdna repaironcogeneschromatin remodelingbrca1-deficient cellscell cyclebrca1 tumor suppressorgenome instabilitycancer geneticsfork protectioncarcinogenesiscell biologydna replication

Extrachromosomal Telomere Dna Derived From Excessive Strand Displacements. Proceedings of the National Academy of Sciences (2024)

Junyeop LeeJina LeeEric J. SohnAngelo TaglialatelaRoderick J. O’SullivanAlberto CicciaJaewon Min

geneticshuman geneticshealth sciencesgenomicsmolecular biologygenome biologyepigenomicsexcessive strand displacementscytogenetics

Mapping Multimodal Phenotypes to Perturbations in Cells and Tissue With Crisprmap. Nature Biotechnology (2024)

Jiacheng GuAbhishek IyerBen WesleyAngelo TaglialatelaGiuseppe LeuzziSho HangaiAubrianna DeckerRuoyu GuNaomi KlicksteinYuanlong ShuaiKristina JankovicLucy Parker-BurnsYinuo JinJia Yi ZhangJustin HongXiang NiuJonathon A. CostaMikael G. PezetJacqueline ChouHans-Willem SnoeckDan A. LandauElham AziziEdmond M. ChanAlberto CicciaJellert T. Gaublomme

tissue imagingsynthetic biologybioprospectingcell biologyprotein sciencevascular biologymultimodal phenotypesbiologymolecular cell biologygene expressionmultimodal transportbiomedical imagingbiotechnologybiological imagingcrisprfunctional genomicscancer imagingsystems biologybiomedical modeling

Smarcal1 is a Dual Regulator of Innate Immune Signaling and Pd-L1 Expression That Promotes Tumor Immune Evasion. Cell (2024)

Giuseppe LeuzziAlessandro VasciaveoAngelo TaglialatelaXiao ChenTessa M. FirestoneAllison R. HickmanWendy MaoTanay ThakarAlina VaitsiankovaJen-Wei HuangRaquel Cuella-MartinSamuel B. HaywardJordan S. KesnerAli GhasemzadehTarun S. NambiarPatricia HoAlexander RialdiMaxime HebrardYinglu LiJinmei GaoSaarang GopinathOluwatobi A. AdelekeBryan J. VentersCharles G. DrakeRichard BaerBenjamin IzarErnesto GuccioneMichael-Christopher KeoghRaphael GueroisLu SunChao LuAndrea CalifanoAlberto Ciccia

dual regulatorcancer immunotherapycancer biologygene expressioninnate immunecancer researchoncologyinnate immune systemcell regulationcell signalingimmunologytumor immune evasioncell biology

Arginine Shortage Induces Replication Stress and Confers Genotoxic Resistance by Inhibiting Histone H4 Translation and Promoting Pcna Ubiquitination. Cell Reports (2023)

Yi-Chang WangAndrew A. KelsoAdak KaramafroozYi-Hsuan ChenWei-Kai ChenChun-Ting ChengYue QiLong GuLinda MalkasAngelo TaglialatelaHsing-Jien KungGeorge-Lucian MoldovanAlberto CicciaJeremy M. StarkDavid K. Ann

pharmacologygene expressiongene therapyenzyme inhibitiontumor biologyimmunologymedicinal researchepigeneticscell biologypcna ubiquitination

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Angelo Taglialatela

Associate Research Scientist in the Department of Genetics and Development

Columbia University

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Angelo Taglialatela

Columbia University

Associate Research Scientist in the Department of Genetics and Development

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Endogenous Sources of Abasic Sites and Implications for Dna Replication: Mechanisms of Fork Stalling and Recovery. Annual Review of Biochemistry (2026)

nucleic acid chemistrymolecular cell biologybiochemistrynucleic acidsmolecular biologygenome instabilitydna replicationenzymes

Author Correction: Mapping Multimodal Phenotypes to Perturbations in Cells and Tissue With Crisprmap. Nature Biotechnology (2025)

Distinct Mechanisms Underlying Extrachromosomal Telomere Dna Generation in Alt Cancers. Nucleic Acids Research (2025)

geneticsmolecular cancerdna repaircancer researchchromosomal rearrangementscancer genomicsdna generationradiation oncologygenome instabilitygenome biologycancer geneticscarcinogenesisepigenetics

Abstract B023: Smarcal1 is a Novel Candidate Therapeutic Target for Alt-Positive Osteosarcoma. Cancer Research (2024)

Angelo TaglialatelaXiao ChenZahra Fatema KhanFilemon Dela CruzDua ShiviDillon OswaldAzeroglu BenuraEros Lazzerini DenchiMin JaewonAndrew L. KungAlberto Ciccia

Abstract Pr010: Understanding Extrachromosomal Telomere Generation in Alt Cancers. Cancer Research (2024)

Junyeop LeeJina LeeEric J. SohnAngelo TaglialatelaRoderick J. O’SullivanAlberto CicciaJaewon Min

cancer biologyhealth sciencescancer researchoncologycancer genomicsradiation oncologyalt cancerscancer geneticstumor biologyclinical researchdermatologymedicinal researchvascular biology

Brca1 and 53Bp1 Regulate Reprogramming Efficiency by Mediating Dna Repair Pathway Choice at Replication-Associated Double-Strand Breaks. Cell Reports (2024)

Daniela GeorgievaNing WangAngelo TaglialatelaStepan JerabekColleen R. ReczekPei Xin LimJulie SungQian DuMichiko HoriguchiMaria JasinAlberto CicciaRichard BaerDieter Egli

Extrachromosomal Telomere Dna Derived From Excessive Strand Displacements. Proceedings of the National Academy of Sciences (2024)

Junyeop LeeJina LeeEric J. SohnAngelo TaglialatelaRoderick J. O’SullivanAlberto CicciaJaewon Min

geneticshuman geneticshealth sciencesgenomicsmolecular biologygenome biologyepigenomicsexcessive strand displacementscytogenetics

Mapping Multimodal Phenotypes to Perturbations in Cells and Tissue With Crisprmap. Nature Biotechnology (2024)

Jiacheng GuAbhishek IyerBen WesleyAngelo TaglialatelaGiuseppe LeuzziSho HangaiAubrianna DeckerRuoyu GuNaomi KlicksteinYuanlong ShuaiKristina JankovicLucy Parker-BurnsYinuo JinJia Yi ZhangJustin HongXiang NiuJonathon A. CostaMikael G. PezetJacqueline ChouHans-Willem SnoeckDan A. LandauElham AziziEdmond M. ChanAlberto CicciaJellert T. Gaublomme

Smarcal1 is a Dual Regulator of Innate Immune Signaling and Pd-L1 Expression That Promotes Tumor Immune Evasion. Cell (2024)

dual regulatorcancer immunotherapycancer biologygene expressioninnate immunecancer researchoncologyinnate immune systemcell regulationcell signalingimmunologytumor immune evasioncell biology

Arginine Shortage Induces Replication Stress and Confers Genotoxic Resistance by Inhibiting Histone H4 Translation and Promoting Pcna Ubiquitination. Cell Reports (2023)

pharmacologygene expressiongene therapyenzyme inhibitiontumor biologyimmunologymedicinal researchepigeneticscell biologypcna ubiquitination

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