Faculty

Institution

Unit

Venue

Amy Andreotti

Roy J Carver Chair and University Professor of Biochemistry Biophysics and Molecular Biology

Iowa State University

Affiliations

College of Liberal Arts and Sciences

Biochemistry, Biophysics, and Molecular Biology

College of Agriculture and Life Sciences

Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology

Amy Andreotti is currently serving as a Biochemistry, Biophysics, And Molecular Biology Roy J Carver Chair and University Professor of Biochemistry Biophysics and Molecular Biology at Iowa State University.

Honors

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Experiences

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Education

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Amy Andreotti

Iowa State University

Roy J Carver Chair and University Professor of Biochemistry Biophysics and Molecular Biology

You can click a keyword to filter the displayed items

molecular biology immunology protein science pharmacology biochemistry cell signaling structural biology enzymes signal transduction protein structure medicinal research enzyme inhibition protein function membrane biology receptor tyrosine kinases immune responses tumor biology structural molecular biology molecular regulation cell regulation tyrosine kinase protein chemistry molecular science molecular physiology cancer biology drug targeting biomolecular structure molecular docking cellular immune responses protein phosphorylation cancer genetics conformational studies cellular biochemistry mammalian biology liver physiology adaptive immune system biomolecular interactions host factors regulatory domains tec family kinases peptide science redox biology peptides biochemical sciences molecular cell biology genetic basis signaling pathways enzyme catalysis molecular research gene regulation tec family kinase proline isomerization conformational state tec kinase itk tec kinases solution nmr coordination chemistry molecular switches cell interactions functional regulation biological function purification method protein purification protein expression molecular self-assembly biological inorganic chemistry protein nmr plant biology plant genetics impossible cross-peaks bulk water tec family peptidyl-prolyl isomerase cyclophilin tyrosine kinase itk intrinsic molecular switch tcr signal strength protein structure prediction

Notable Scholarly Works

Notable Federal Grants

Collaborators

Conformational Heterogeneity of the Btk Phth Domain Drives Multiple Regulatory States. eLife (2024)

David Yin-wei LinLauren E KuefferPuneet JunejaThomas E WalesJohn R EngenAmy H Andreotti

conformational heterogeneityconformational studiesimmunologyelectrophysiologymolecular biologygenetics

Elife Assessment: Allosteric Coupling Asymmetry Mediates Paradoxical Activation of Braf by Type II Inhibitors. (2024)

Amy H Andreotti

enzyme inhibitiontype ii inhibitorsmolecular biologyelife assessment

Elife Assessment: Conformation Selection by Atp-Competitive Inhibitors and Allosteric Communication in Erk2. (2024)

Amy H Andreotti

conformation selectionelife assessmentallosteric communicationatp-competitive inhibitors

Elife Assessment: Dtx3l Ubiquitin Ligase Ubiquitinates Single-Stranded Nucleic Acids. (2024)

Amy H Andreotti

single-stranded nucleic acidsnucleic acidsmolecular biology

Elife Assessment: Probing Pac1 Receptor Activation Across Species With an Engineered Sensor. (2024)

Amy H Andreotti

sensorssensing mechanismsreceptorsmolecular biology

Elife Assessment: The αC-β4 Loop Controls the Allosteric Cooperativity Between Nucleotide and Substrate in the Catalytic Subunit of Protein Kinase A. (2024)

Amy H Andreotti

catalytic subunitenzymesprotein scienceallosteric cooperativityprotein kinasebiochemistrymolecular biology

Elife Assessment: Uncovering the Bin1-Sh3 Interactome Underpinning Centronuclear Myopathy. (2024)

Amy H Andreotti

interactomicsmolecular biology

Elife Assessment: Water and Chloride as Allosteric Inhibitors in Wnk Kinase Osmosensing. (2024)

Amy H Andreotti

allosteric inhibitorselife assessmentwnk kinasebiochemistry

Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A Btk Story. Journal of Medicinal Chemistry (2024)

Ruxandra MoraruBeatriz Valle-ArgosAnnabel MintonLara BuermannSuyin PanThomas E. WalesRaji E. JosephAmy H. AndreottiJonathan C. StreffordGraham PackhamMatthias G. J. Baud

targeted covalent inhibitiondrug targetingpharmacologytherapeutic targetsdrug deliverypharmaceutical chemistrypeptidesmolecular biologydrug discoverynanoparticle researchbiomolecular engineeringnanomedicinemedicinal researchmedicinal chemistrybtk storytumor targetingpeptide sciencerational drug designenzyme inhibitionchemical warfare agent

Impact of the Clinically Approved Btk Inhibitors on the Conformation of Full-Length Btk and Analysis of the Development of Btk Resistance Mutations in Chronic Lymphocytic Leukemia. eLife (2024)

Raji E JosephThomas E WalesSandrine JayneRobert G BrittonD Bruce FultonJohn R EngenMartin JS DyerAmy H Andreotti

therapy resistanceanti-cancer agentschronic lymphocytic leukemiabtk resistance mutationsimmunologydermatologypharmacologyimmunotherapycancer researchcancer geneticsdrug discoverycancer treatmentmedicinal researchmolecular cancercellular therapyfull-length btkpathway analysisbtk inhibitorsmolecular medicineleukemiaenzyme inhibitiononcology

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Amy Andreotti

Roy J Carver Chair and University Professor of Biochemistry Biophysics and Molecular Biology

Iowa State University

Affiliations

College of Liberal Arts and Sciences

Biochemistry, Biophysics, and Molecular Biology

College of Agriculture and Life Sciences

Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Amy Andreotti

Iowa State University

Roy J Carver Chair and University Professor of Biochemistry Biophysics and Molecular Biology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Conformational Heterogeneity of the Btk Phth Domain Drives Multiple Regulatory States. eLife (2024)

David Yin-wei LinLauren E KuefferPuneet JunejaThomas E WalesJohn R EngenAmy H Andreotti

conformational heterogeneityconformational studiesimmunologyelectrophysiologymolecular biologygenetics

Elife Assessment: Allosteric Coupling Asymmetry Mediates Paradoxical Activation of Braf by Type II Inhibitors. (2024)

Amy H Andreotti

enzyme inhibitiontype ii inhibitorsmolecular biologyelife assessment

Elife Assessment: Conformation Selection by Atp-Competitive Inhibitors and Allosteric Communication in Erk2. (2024)

Amy H Andreotti

conformation selectionelife assessmentallosteric communicationatp-competitive inhibitors

Elife Assessment: Dtx3l Ubiquitin Ligase Ubiquitinates Single-Stranded Nucleic Acids. (2024)

Amy H Andreotti

single-stranded nucleic acidsnucleic acidsmolecular biology

Elife Assessment: Probing Pac1 Receptor Activation Across Species With an Engineered Sensor. (2024)

Amy H Andreotti

sensorssensing mechanismsreceptorsmolecular biology

Elife Assessment: The αC-β4 Loop Controls the Allosteric Cooperativity Between Nucleotide and Substrate in the Catalytic Subunit of Protein Kinase A. (2024)

Amy H Andreotti

catalytic subunitenzymesprotein scienceallosteric cooperativityprotein kinasebiochemistrymolecular biology

Elife Assessment: Uncovering the Bin1-Sh3 Interactome Underpinning Centronuclear Myopathy. (2024)

Amy H Andreotti

interactomicsmolecular biology

Elife Assessment: Water and Chloride as Allosteric Inhibitors in Wnk Kinase Osmosensing. (2024)

Amy H Andreotti

allosteric inhibitorselife assessmentwnk kinasebiochemistry

Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A Btk Story. Journal of Medicinal Chemistry (2024)

Ruxandra MoraruBeatriz Valle-ArgosAnnabel MintonLara BuermannSuyin PanThomas E. WalesRaji E. JosephAmy H. AndreottiJonathan C. StreffordGraham PackhamMatthias G. J. Baud

Impact of the Clinically Approved Btk Inhibitors on the Conformation of Full-Length Btk and Analysis of the Development of Btk Resistance Mutations in Chronic Lymphocytic Leukemia. eLife (2024)

Raji E JosephThomas E WalesSandrine JayneRobert G BrittonD Bruce FultonJohn R EngenMartin JS DyerAmy H Andreotti

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