Faculty

Institution

Unit

Venue

K. Allen

Professor

Boston University

Affiliations

College of Arts & Sciences

Chemistry

K. Allen is currently serving as a Chemistry Professor at Boston University.

Honors

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Experiences

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Education

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K. Allen

Boston University

Professor

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biochemistry enzymes molecular biology protein science structural biology protein structure structural molecular biology pharmacology biophysics biomolecular structure enzyme catalysis membrane biology biological chemistry enzyme inhibition protein chemistry crystallography catalysis biocatalysis x-ray crystallography proteomics structure-function enzyme kinetics protein engineering molecular substrates enzyme specificity protein x-ray crystallography biochemical sciences biological macromolecules structural chemistry redox biology molecular structure microbial physiology substrate specificity botulinum neurotoxin peptides transition metal chemistry molecular catalysis protein bioinformatics glycosylation structural bioinformatics crystal structures functional modification haloalkanoic acid dehalogenase genome biology biomolecules molecular microbiology pharmaceutical chemistry protein phosphorylation structure elucidation biological inorganic chemistry haloacid dehalogenase biomedical imaging coordination chemistry microbial genetics bacteriology structural composition biochemical genetics structural design biochemical interaction carbohydrate-protein interactions biological function biomolecular interactions catalytic diversity pentacovalent phosphorus intermediate phosphoryl transfer reaction catalytic scaffold phosphoryl group transfer high affinity double-lanthanide-binding tags light chain phosphate aldolase biochemical function monotopic phosphoglycosyl transferase structural determinants macromolecular systems secretory pathway macromolecular chemistry biomolecular engineering bioorganic chemistry enzymatic modification

Notable Scholarly Works

Notable Federal Grants

Collaborators

Dual Glycosyltransferases From Campylobacter Concisus Diverge From the Canonical Campylobacter N-Linked Glycan Assembly Pathway. Biochemistry (2024)

Christine A. ArbourNemanja VuksanovicKaren N. AllenBarbara Imperiali

dual glycosyltransferasesbiological macromoleculesbiotransformationglycosylationbioenergeticscarbohydrate chemistryenzymesbiomoleculessequence assemblymembrane biologybiosynthesisbioconjugationmolecular metabolismpolysaccharidesglycobiologybiomolecular engineeringmolecular biologystructural molecular biologymicrobiology

Functionally Validated Proteome-Wide Bioinformatic Annotation of the Monotopic Phosphoglycosyl Transferase Family. (2024)

Theo DurandGreg J DodgeRoxanne P SiudaHugh R HiginbothamChristine A ArbourSoumi GhoshKaren N AllenBarbara Imperiali

proteomicsproteome-wide bioinformatic annotationbiological engineeringhealth sciencesbioinformatics

Proteome-Wide Bioinformatic Annotation and Functional Validation of the Monotopic Phosphoglycosyl Transferase Superfamily. Proceedings of the National Academy of Sciences (2024)

T DurandGJ DodgeRP SiudaHR HiginbothamCA ArbourS Ghosh...

monotopic phosphoglycosyl transferaseproteome-wide bioinformatic annotationproteomicsfunctional validationmolecular biologyprotein sciencebiochemistry

Structural Basis for the Improved Rna-Clamping of Amidino-Rocaglates to Eif4a1. bioRxiv (Cold Spring Harbor Laboratory) (2024)

James F. ConleyLauren E. BrownJames H. McNeelyJerry PelletierJohn A. PorcoKaren N. Allen

biomolecular structureimproved rna-clampingmolecular biologystructural biologystructural basisbiochemistry

A Conserved Core Region of the Scaffold Nemo is Essential for Signal-Induced Conformational Change and Liquid-Liquid Phase Separation. Journal of Biological Chemistry (2023)

Christopher J. DiRussoAnthony M. DeMariaJudy WongWei WangJack J. JordanidesAdrian WhittyKaren N. AllenThomas D. Gilmore

liquid-liquid phase separationsignal-induced conformational changesystems biologymolecular and cellular biologymammalian biologyscaffold nemocore regioncell and molecular biologydevelopmental biologystructural biologyprotein scienceneuroscience

Characterization of Pglj, a Glycosyltransferase in the Campylobacter Concisus N-Linked Protein Glycosylation Pathway That Expands Glycan Diversity. Biochemistry (2023)

Christine A. ArbourNemanja VuksanovicHannah M. BernsteinKaren N. AllenBarbara Imperiali

glycan diversitymicrobial pathogenesismicrobial physiologymolecular microbiologymicrobial geneticsenzymesinfectious diseasesmicrobiologybiochemistry

Co‐Conserved Sequence Motifs Are Predictive of Substrate Specificity in a Family of Monotopic Phosphoglycosyl Transferases. Protein Science (2023)

AJ AndersonGJ DodgeKN AllenB Imperiali

protein chemistryprotein bioinformaticsco-conserved sequence motifsenzymessequence motifmolecular biologymonotopic phosphoglycosyl transferasesstructural biologysubstrate specificityprotein scienceprotein engineeringbiological engineeringbiochemistry

MENTAT: A Machine-Learning Approach for the Identification of Mutations to Increase Protein Stability. Proceedings of the National Academy of Sciences (2023)

Samantha N. MuellersKaren N. AllenAdrian Whitty

genomicssequence analysisprotein stabilitygeneticscomputational genomicsmolecular biologycomputational biologymachine learningbioinformatics

Protein-Metabolite Interactomics of Carbohydrate Metabolism Reveal Regulation of Lactate Dehydrogenase. Science (2023)

KG HicksAA CluntunHL SchubertSR HackettJA BergPG Leonard...

lactate dehydrogenaseprotein-metabolite interactomicsproteomicsbiochemistry

Specificity Determinants Revealed by the Structure of Glycosyltransferase Campylobacter Concisus Pgla. Protein Science (2023)

Nemanja VuksanovicJozlyn R. ClasmanBarbara ImperialiKaren N. Allen

protein chemistrymicrobial pathogenesismicrobial physiologyprotein structureenzymesmolecular biologystructural molecular biologyspecificity determinantsstructural biologyprotein sciencemicrobiologybiochemistry

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K. Allen

Professor

Boston University

Affiliations

College of Arts & Sciences

Chemistry

K. Allen is currently serving as a Chemistry Professor at Boston University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

K. Allen

Boston University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Dual Glycosyltransferases From Campylobacter Concisus Diverge From the Canonical Campylobacter N-Linked Glycan Assembly Pathway. Biochemistry (2024)

Christine A. ArbourNemanja VuksanovicKaren N. AllenBarbara Imperiali

Functionally Validated Proteome-Wide Bioinformatic Annotation of the Monotopic Phosphoglycosyl Transferase Family. (2024)

Theo DurandGreg J DodgeRoxanne P SiudaHugh R HiginbothamChristine A ArbourSoumi GhoshKaren N AllenBarbara Imperiali

proteomicsproteome-wide bioinformatic annotationbiological engineeringhealth sciencesbioinformatics

Proteome-Wide Bioinformatic Annotation and Functional Validation of the Monotopic Phosphoglycosyl Transferase Superfamily. Proceedings of the National Academy of Sciences (2024)

T DurandGJ DodgeRP SiudaHR HiginbothamCA ArbourS Ghosh...

monotopic phosphoglycosyl transferaseproteome-wide bioinformatic annotationproteomicsfunctional validationmolecular biologyprotein sciencebiochemistry

Structural Basis for the Improved Rna-Clamping of Amidino-Rocaglates to Eif4a1. bioRxiv (Cold Spring Harbor Laboratory) (2024)

James F. ConleyLauren E. BrownJames H. McNeelyJerry PelletierJohn A. PorcoKaren N. Allen

biomolecular structureimproved rna-clampingmolecular biologystructural biologystructural basisbiochemistry

A Conserved Core Region of the Scaffold Nemo is Essential for Signal-Induced Conformational Change and Liquid-Liquid Phase Separation. Journal of Biological Chemistry (2023)

Christopher J. DiRussoAnthony M. DeMariaJudy WongWei WangJack J. JordanidesAdrian WhittyKaren N. AllenThomas D. Gilmore

Characterization of Pglj, a Glycosyltransferase in the Campylobacter Concisus N-Linked Protein Glycosylation Pathway That Expands Glycan Diversity. Biochemistry (2023)

Christine A. ArbourNemanja VuksanovicHannah M. BernsteinKaren N. AllenBarbara Imperiali

glycan diversitymicrobial pathogenesismicrobial physiologymolecular microbiologymicrobial geneticsenzymesinfectious diseasesmicrobiologybiochemistry

Co‐Conserved Sequence Motifs Are Predictive of Substrate Specificity in a Family of Monotopic Phosphoglycosyl Transferases. Protein Science (2023)

AJ AndersonGJ DodgeKN AllenB Imperiali

MENTAT: A Machine-Learning Approach for the Identification of Mutations to Increase Protein Stability. Proceedings of the National Academy of Sciences (2023)

Samantha N. MuellersKaren N. AllenAdrian Whitty

genomicssequence analysisprotein stabilitygeneticscomputational genomicsmolecular biologycomputational biologymachine learningbioinformatics

Protein-Metabolite Interactomics of Carbohydrate Metabolism Reveal Regulation of Lactate Dehydrogenase. Science (2023)

KG HicksAA CluntunHL SchubertSR HackettJA BergPG Leonard...

lactate dehydrogenaseprotein-metabolite interactomicsproteomicsbiochemistry

Specificity Determinants Revealed by the Structure of Glycosyltransferase Campylobacter Concisus Pgla. Protein Science (2023)

Nemanja VuksanovicJozlyn R. ClasmanBarbara ImperialiKaren N. Allen

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