Faculty

Institution

Unit

Venue

Alireza Ali Karimi

Assistant Professor of Ophthalmology

Oregon Health & Science University

Affiliations

OHSU School of Medicine

Department Of Ophthalmology

Institute Of Casey Eye

Oregon Health & Science University

Alireza (Ali) Karimi is an Assistant Professor of Ophthalmology at Oregon Health & Science University. His research integrates biomedical engineering, biophysics, and mechanobiology to investigate ocular tissue biomechanics, with a focus on the trabecular meshwork and optic nerve head. His recent work employs advanced traction force microscopy and viscoelastic modeling to elucidate how matrix stiffness and cytoskeletal dynamics drive collagen reorganization in glaucomatous tissues, alongside computational studies of aqueous humor dynamics and aging effects. He also applies deep learning to electronic health records for early glaucoma detection. His publications appear in venues such as *Matter*, *Acta Biomaterialia*, and *Investigative Ophthalmology & Visual Science*.

Honors

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Alireza Ali Karimi

Oregon Health & Science University

Assistant Professor of Ophthalmology

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biomedical engineering ophthalmology biomechanics biophysics mechanobiology medicine cardiovascular research vascular biology trabecular meshwork cell biomechanics biomechanical engineering ocular surface visual science biomedical modeling ocular tissues computational biology glaucoma cellular physiology biomedical imaging ophthalmology retina biomaterials tissue engineering microstructure matrix biology mechanotransduction aqueous humour ocular biomechanics scientific computing bone research applied physiology biomedical informatics biomedical technologies biomedical computing in vivo systems biomaterial modeling comparative analysis dental biomechanics healthcare engineering biomedical flows vision research plaque vulnerability human eye comparative study human trabecular meshwork traction forces aqueous humor dynamics biofabrication orthodontics thrombosis resuscitation interfacial studies biomaterials design residual stress transfusion medicine hemostasis orthodontic research computational medicine hyperthermia tissue imaging digestive tract medical biophysics biliary tract renal function treatment and prevention vascular adaptation spinal biomechanics clinical medicine balloon expandable stent stenotic artery lamina cribrosa microstructure posterior pole finite element type biomechanical model mechanical characterization tissue engineering applications constitutive equations laboratory investigation medical optical imaging neuro-ophthalmology confocal microscopy anatomy visual system vision rehabilitation eye tracking visual perception facial plastic surgery

Notable Scholarly Works

Notable Federal Grants

Collaborators

3D Traction Force Microscopy in Human Trabecular Meshwork Tissues: Effects of Rock and Yap/Taz Inhibition in Normal and Glaucomatous Tissues. Tissue and Cell (2025)

biophysicscell biomechanicstrabecular meshworkocular tissuestissue physiologymechanobiologyglaucomaophthalmology retinabiomedical engineeringmatrix biologyyap/taz inhibitionophthalmologytissue (biology)traction force microscopyocular surfaceglaucomatous tissues

Actin-Microtubule Synergy Dominates Force Transmission and Collagen Strain in Human Trabecular Meshwork. Acta Biomaterialia (2025)

biophysicscell biomechanicshuman trabecular meshworkcollagen straincytoskeletoncell biologymechanobiologyactin-microtubule synergy dominatescell motilitybiomedical engineeringmolecular motorsmatrix biologycellular structuremechanotransductionbiomechanicscellular physiology

Impact of Aging on Anterior Segment Morphology and Aqueous Humor Dynamics in Human Eyes: Advanced Imaging and Computational Techniques. Journal of Applied Biomedicine (2025)

visual systemadvanced imagingvisual scienceocular tissuesaqueous humor dynamicsvision researchanterior segment morphologyneuro-ophthalmologyglaucomaophthalmology retinabiomedical engineeringretinaaqueous humourophthalmology

Matrix Stiffness Regulates Traction Forces, Cytoskeletal Dynamics, and Collagen Reorganization in Trabecular Meshwork Cells in Glaucoma. Matter (2025)

matrix stiffnesscell biomechanicstraction forcescollagen reorganizationcytoskeletontrabecular meshworkcell biologymechanobiologycell-matrix interactionsmatrix biologyophthalmologymechanotransductionbiomechanicscellular physiology

Response to “Scientific Concerns About Recent Fluid-Structure Interaction Models of the Aqueous Humor Outflow Pathway”. Investigative Ophthalmology & Visual Science (2025)

biophysicsfluid sciencefluid dynamicsfluid mechanicsfluid flowsystems biologyscientific concernsfluid-solid interactionsbiofluid dynamics

Viscoelastic Modeling of Optic Nerve Head Biomechanics: Effects of Intraocular and Cerebrospinal Fluid Pressure. Journal of Applied Biomedicine (2025)

visual sciencetrabecular meshworkocular tissuesoptic nerveneuro-ophthalmologymechanobiologyophthalmology retinabiomedical engineeringophthalmologyocular surfacebiomechanics

Biomechanics of the Optic Nerve Head. Elsevier eBooks (2024)

Comparative Analysis of Traction Forces in Normal and Glaucomatous Trabecular Meshwork Cells Within a 3D, Active Fluid-Structure Interaction Culture Environment. Acta Biomaterialia (2024)

Alireza KarimiMini AgaTaaha KhanSiddharth Daniel D'costaOmkar ThawareElizabeth WhiteMary J. KelleyHaiyan GongTed S. Acott

tissue engineeringcell biomechanicstraction forcesmechanical sciencebiomedical engineeringmaterials sciencebiomechanicsbiomaterialsmechanical engineering

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches. Investigative Ophthalmology & Visual Science (2024)

Ted S. AcottMichael P. FautschWeiming MaoC. Ross EthierAlex S. HuangMary J. KelleyMini AgaSanjoy K. BhattacharyaTerete BorrasDiane BovenkampUttio Roy ChowdhuryAbbot F. ClarkMohammed I. DibasYiqin DuMichael H. ElliottJennifer A. FaralliHaiyan GongSamuel HerbergMurray A. JohnstonePaul L. KaufmanKate E. KellerRuth A. KellyDavid KrizajMarkus H. KuehnHoi Lam LiRaquel LiebermanShan C. LinYutao LiuFiona S. McDonnellColleen M. McDowellGillian J. McLellanPhilip MzykKayarat Saidas NairDarryl R. OverbyDonna M. PetersVijayKrishna RaghunathanPonugoti Vasantha RaoGavin W. RoddyNajam A. SharifMyoung Sup ShimYang SunBenjamin R. ThomsonCarol B. TorisColin E. WilloughbyHao F. ZhangThomas F. FreddoRudolf FuchshoferKamisha R. HillAlireza KarimiKrishnakumar KizhatilCasey C. KopcyznskiPaloma LitonGaurang PatelMichael PengPadmanabhan P. PattabiramanGanesh PrasannaEster Reina-TorresE. Griffen SamplesJohn R. SamplesCynthia L. SteelClemens A. StrohmaierPreeti SubramanianChenna Kesavulu SugaliJoseph van Batenburg-SherwoodCydney WongHannah YoungbloodGulab S. ZodeElizabeth WhiteW. Daniel Stamer

visual scienceocular tissuesintraocular pressure regulationvision researchocular surface physiologyophthalmologyoutflow facilityexperimental ophthalmologyocular surfacemedical optical imaging

High-Resolution Modeling of Aqueous Humor Dynamics in the Conventional Outflow Pathway of a Normal Human Donor Eye. Computer Methods and Programs in Biomedicine (2024)

Alireza KarimiReza RazaghiAnsel StanikSiddharth Daniel D'costaIman MirafzalMary J KelleyTed S AcottHaiyan Gong

biophysicsbiomedical informaticsscientific computingbiomedical imagingaqueous humor dynamicsfeedback loopsystems biologycomputational biologyhigh-resolution modelingaqueous humourophthalmologybiomedical computingconventional outflow pathwaymedical optical imagingbiomedical modeling

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Alireza Ali Karimi

Assistant Professor of Ophthalmology

Oregon Health & Science University

Affiliations

OHSU School of Medicine

Department Of Ophthalmology

Institute Of Casey Eye

Oregon Health & Science University

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Alireza Ali Karimi

Oregon Health & Science University

Assistant Professor of Ophthalmology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

3D Traction Force Microscopy in Human Trabecular Meshwork Tissues: Effects of Rock and Yap/Taz Inhibition in Normal and Glaucomatous Tissues. Tissue and Cell (2025)

Actin-Microtubule Synergy Dominates Force Transmission and Collagen Strain in Human Trabecular Meshwork. Acta Biomaterialia (2025)

Impact of Aging on Anterior Segment Morphology and Aqueous Humor Dynamics in Human Eyes: Advanced Imaging and Computational Techniques. Journal of Applied Biomedicine (2025)

Matrix Stiffness Regulates Traction Forces, Cytoskeletal Dynamics, and Collagen Reorganization in Trabecular Meshwork Cells in Glaucoma. Matter (2025)

Response to “Scientific Concerns About Recent Fluid-Structure Interaction Models of the Aqueous Humor Outflow Pathway”. Investigative Ophthalmology & Visual Science (2025)

biophysicsfluid sciencefluid dynamicsfluid mechanicsfluid flowsystems biologyscientific concernsfluid-solid interactionsbiofluid dynamics

Viscoelastic Modeling of Optic Nerve Head Biomechanics: Effects of Intraocular and Cerebrospinal Fluid Pressure. Journal of Applied Biomedicine (2025)

visual sciencetrabecular meshworkocular tissuesoptic nerveneuro-ophthalmologymechanobiologyophthalmology retinabiomedical engineeringophthalmologyocular surfacebiomechanics

Biomechanics of the Optic Nerve Head. Elsevier eBooks (2024)

Comparative Analysis of Traction Forces in Normal and Glaucomatous Trabecular Meshwork Cells Within a 3D, Active Fluid-Structure Interaction Culture Environment. Acta Biomaterialia (2024)

Alireza KarimiMini AgaTaaha KhanSiddharth Daniel D'costaOmkar ThawareElizabeth WhiteMary J. KelleyHaiyan GongTed S. Acott

tissue engineeringcell biomechanicstraction forcesmechanical sciencebiomedical engineeringmaterials sciencebiomechanicsbiomaterialsmechanical engineering

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches. Investigative Ophthalmology & Visual Science (2024)

visual scienceocular tissuesintraocular pressure regulationvision researchocular surface physiologyophthalmologyoutflow facilityexperimental ophthalmologyocular surfacemedical optical imaging

High-Resolution Modeling of Aqueous Humor Dynamics in the Conventional Outflow Pathway of a Normal Human Donor Eye. Computer Methods and Programs in Biomedicine (2024)

Alireza KarimiReza RazaghiAnsel StanikSiddharth Daniel D'costaIman MirafzalMary J KelleyTed S AcottHaiyan Gong

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