Faculty

Institution

Unit

Venue

Alejandro Soto Gutierrez

Professor

University of Pittsburgh

Affiliations

Medicine

Interdisciplinary Biomedical Graduate Program

Pathology

Alejandro Soto Gutierrez is currently serving as an Interdisciplinary Biomedical Graduate Program Professor at University of Pittsburgh.

Honors

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Experiences

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Education

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Alejandro Soto Gutierrez

University of Pittsburgh

Professor

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regenerative medicine hepatology transplantation medicine cell biology biomedical engineering cell transplantation organ transplantation tissue engineering liver transplantation stem cell research genetics health sciences medicinal research hematology liver physiology liver disease clinical transplantation vascular biology stem cell transplantation membrane biology mammalian biology cellular therapy stem cells transplant surgery tissue transplantation gastroenterology digestive diseases acute liver failure graft survival cancer biology transplantation proceeding induced pluripotent stem cells cancer genetics biomedical modeling bone marrow transplantation biofabrication animal physiology stem-cell therapy mammalian physiology hepatocyte transplantation deleted variant redox biology clinical investigation treatment development genomic medicine energy metabolism metabolic regulation cell therapy human hepatocytes immunomodulation embryonic stem cells graft rejection molecular regulation gene function clinical medicine renal function drug development experimental biology bioengineering model biomaterial modeling histocompatibility apoptosis signaling pathways stem cell-derived hepatocytes human fetal hepatocytes liver repopulation endoderm induction end-stage liver disease feeder-free conditions artificial device liver graft liver replacement human-scale whole-organ bioengineering systemic inflammation successful treatment transplantation therapy medicine developmental biology regeneration (biology) liver preservation translational medicine

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Metabolic Dysfunction-Associated Steatotic Liver Acinus Biomimetic Induces Pancreatic Islet Dysfunction in a Coupled Microphysiology System. Communications Biology (2024)

Julio AlemanRavikumar KConnor WiegandMark E. SchurdakLawrence VernettiDillon GavlockCeleste ReeseRichard DeBiasioGreg LaRoccaYulder Daniel AngaritaAlbert GoughAlejandro Soto-GutierrezJaideep BehariVijay K. YechoorMark T. MiedelAndrew M. SternIpsita BanerjeeD. Lansing Taylor

liver physiologydiabetescoupled microphysiology systemmetabolic regulationsystems biologymetabolic syndromebiologymolecular metabolismcomplex biological systemsbiosystemsmetabolic controlmetabolismmolecular physiologymetabolic pathwaysbiochemistrycell metabolism

A Rat Model of Cirrhosis With Well-Differentiated Hepatocellular Carcinoma Induced by Thioacetamide. Frontiers in Gastroenterology (2024)

Zhiping HuTakeshi KuriharaYiyue SunZeliha CetinRodrigo M. FlorentinoLanuza A. P. FaccioliZhenghao LiuBo YangAlina OstrowskaJoseph D. LockerAlejandro Soto-GutierrezEvan R. Delgado

well-differentiated hepatocellular carcinomaradiologypharmacologyliver cancerepidemiologyvascular biologyrat modeloncologyhepatologymedicinal researchhepatocellular carcinoma

Comparison of Wild-Type and High-Risk Pnpla3 Variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-Associated Steatotic Liver Disease Precision Therapy. Frontiers in Cell and Developmental Biology (2024)

Mengying XiaMahboubeh VarmazyadIris Pla-PalacínDillon C GavlockRichard DeBiasioGregory LaRoccaCeleste ReeseRodrigo M FlorentinoLanuza A P FaccioliJacquelyn A BrownLawrence A VernettiMark SchurdakAndrew M SternAlbert GoughJaideep BehariAlejandro Soto-GutierrezD Lansing TaylorMark T Miedel

immunologygenome biologydigestive diseasesclinical lipidologypharmacologygenomic medicinehematologytranslational bioinformaticssurvival analysisgeneticsliver diseasepersonalized medicineallelic varianthepatologymedicinal researchpathway analysisliver physiologymolecular medicine

Long-Read Single-Cell Sequencing Reveals Expressions of Hypermutation Clusters of Isoforms in Human Liver Cancer Cells. eLife (2024)

Silvia LiuYan-Ping YuBao-Guo RenTuval Ben-YehezkelCaroline ObertMat SmithWenjia WangAlina OstrowskaAlejandro Soto-GutierrezJian-Hua Luo

cancer geneticscell researchcell biologygenome biologymolecular cancercancer genomicsmolecular cell biologyhypermutation clusterscancer biologybioinformaticscancer researchsingle-cell analysistumor biologygenomicsgene expressionliver cancersystems biologymolecular biologycancer cells

Stress-Free Bioprinting of Human Primary and Ipsc-Derived Islets With Retained Functionality. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Miranda PoklarK RavikumarConnor WiegandBen MizerakRuiqi WangRodrigo M. FlorentinoZhenghao LiuAlejandro Soto-GutierrezPrashant N. KumtaIpsita Banerjee

ipsc-derived isletsstress-free bioprintinginduced pluripotent stem cellsbiomedical engineering

Variants in Autophagy Genes Mtmr12 and Fam134A Are Putative Modifiers of the Hepatic Phenotype in α1-Antitrypsin Deficiency. Hepatology (2024)

Edgar N. TafalengJie LiYan WangTunda HidvegiAlex Soto-GutierrezAdam E. LockeThomas J. NicholasYung-Chun WangStephen PakMichael H. ChoEdwin K. SilvermanGary A. SilvermanSheng Chih JinIra J. FoxDavid H. Perlmutter

cell deathaffected siblingsautoimmune diseasesautophagy genes mtmr12liver diseasegeneticsclinical proteomicsaffected familydisease gene identificationinborn errors of immunityhepatologyautophagypathologyhuman geneticsliver physiologymolecular medicinegenetic epidemiology

Abstract 2359: Cellular Origin and Functional Contribution of Alternatively Spliced Tissue Factor to the Malignant Progression of Chronic Liver Disease. Cancer Research (2023)

Clayton S. LewisKateryna StoneDamaris KuhnellScott LangevinAlejandro Soto-GutierrezPatrick Van DredenJiang WangJames LuyendykVladimir Bogdanov

splicing variantchronic liver diseasecell biologydisease progressioncancer carecancer managementvascular biologycancer biologyhealth sciencesfunctional contributiondermatologycancer researchhepatologycellular origincancer treatmenttumor biologytissue engineeringoncologymedicinal researchcancer cellstissue factorcellular therapymalignant progression

Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants. International Journal of Molecular Sciences (2023)

Lanuza A. P. FaccioliZeliha CetinZehra N. Kocas-KilicarslanKimberly OrtizYiyue SunZhiping HuTakeshi KuriharaEdgar N. TafalengRodrigo M. FlorentinoZi WangMengying XiaMark T. MiedelD. Lansing TaylorJaideep BehariAlina OstrowskaRobert ConstantineAlbert LiAlejandro Soto-Gutierrez

genomicsgenome biologypharmacologygenomic medicinehematologydrug metabolismepidemiologymolecular sciencegeneticsgenetic variationliver diseasehepatologymedicinal research

Human Hepatocellular Response in Cholestatic Liver Diseases. Organogenesis (2023)

Kimberly OrtizZeliha CetinYiyue SunZhiping HuTakeshi KuriharaEdgar N. TafalengRodrigo M. FlorentinoAlina OstrowskaAlejandro Soto-GutierrezLanuza A.P. Faccioli

physiologycholestatic liver diseaseshuman hepatocellular responsehepatologyhealth sciences

Polymorphisms Associated With Metabolic Dysfunction-Associated Steatotic Liver Disease Influence the Progression of End-Stage Liver Disease. Gastro Hep Advances (2023)

Zehra N. Kocas-KilicarslanZeliha CetinLanuza A.P. FaccioliTakashi MotomuraSriram AmirneniRicardo Diaz-AragonRodrigo M. FlorentinoYiyue SunIris Pla-PalacinMengying XiaMark T. MiedelTakeshi KuriharaZhiping HuAlina OstrowskaZi WangRobert ConstantineAlbert LiD. Lansing TaylorJaideep BehariAlejandro Soto-GutierrezEdgar N. Tafaleng

digestive diseaseshematologyepidemiologynephrologygeneticsvascular biologyliver diseaseend-stage liver diseasegastroenterologyhepatologymetabolismhealth policy

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Alejandro Soto Gutierrez

Professor

University of Pittsburgh

Affiliations

Medicine

Interdisciplinary Biomedical Graduate Program

Pathology

Alejandro Soto Gutierrez is currently serving as an Interdisciplinary Biomedical Graduate Program Professor at University of Pittsburgh.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Alejandro Soto Gutierrez

University of Pittsburgh

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Metabolic Dysfunction-Associated Steatotic Liver Acinus Biomimetic Induces Pancreatic Islet Dysfunction in a Coupled Microphysiology System. Communications Biology (2024)

A Rat Model of Cirrhosis With Well-Differentiated Hepatocellular Carcinoma Induced by Thioacetamide. Frontiers in Gastroenterology (2024)

Zhiping HuTakeshi KuriharaYiyue SunZeliha CetinRodrigo M. FlorentinoLanuza A. P. FaccioliZhenghao LiuBo YangAlina OstrowskaJoseph D. LockerAlejandro Soto-GutierrezEvan R. Delgado

well-differentiated hepatocellular carcinomaradiologypharmacologyliver cancerepidemiologyvascular biologyrat modeloncologyhepatologymedicinal researchhepatocellular carcinoma

Long-Read Single-Cell Sequencing Reveals Expressions of Hypermutation Clusters of Isoforms in Human Liver Cancer Cells. eLife (2024)

Silvia LiuYan-Ping YuBao-Guo RenTuval Ben-YehezkelCaroline ObertMat SmithWenjia WangAlina OstrowskaAlejandro Soto-GutierrezJian-Hua Luo

Stress-Free Bioprinting of Human Primary and Ipsc-Derived Islets With Retained Functionality. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Miranda PoklarK RavikumarConnor WiegandBen MizerakRuiqi WangRodrigo M. FlorentinoZhenghao LiuAlejandro Soto-GutierrezPrashant N. KumtaIpsita Banerjee

ipsc-derived isletsstress-free bioprintinginduced pluripotent stem cellsbiomedical engineering

Variants in Autophagy Genes Mtmr12 and Fam134A Are Putative Modifiers of the Hepatic Phenotype in α1-Antitrypsin Deficiency. Hepatology (2024)

Abstract 2359: Cellular Origin and Functional Contribution of Alternatively Spliced Tissue Factor to the Malignant Progression of Chronic Liver Disease. Cancer Research (2023)

Clayton S. LewisKateryna StoneDamaris KuhnellScott LangevinAlejandro Soto-GutierrezPatrick Van DredenJiang WangJames LuyendykVladimir Bogdanov

Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants. International Journal of Molecular Sciences (2023)

genomicsgenome biologypharmacologygenomic medicinehematologydrug metabolismepidemiologymolecular sciencegeneticsgenetic variationliver diseasehepatologymedicinal research

Human Hepatocellular Response in Cholestatic Liver Diseases. Organogenesis (2023)

Kimberly OrtizZeliha CetinYiyue SunZhiping HuTakeshi KuriharaEdgar N. TafalengRodrigo M. FlorentinoAlina OstrowskaAlejandro Soto-GutierrezLanuza A.P. Faccioli

physiologycholestatic liver diseaseshuman hepatocellular responsehepatologyhealth sciences

Polymorphisms Associated With Metabolic Dysfunction-Associated Steatotic Liver Disease Influence the Progression of End-Stage Liver Disease. Gastro Hep Advances (2023)

digestive diseaseshematologyepidemiologynephrologygeneticsvascular biologyliver diseaseend-stage liver diseasegastroenterologyhepatologymetabolismhealth policy

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