Faculty

Institution

Unit

Venue

Aimee L. Edinger

Professor and Chancellor’s Fellow Developmental & Cell Biology

University of California, Irvine

Affiliations

School of Biological Sciences

Department of Developmental and Cell Biology

School of Pharmacy and Pharmaceutical Sciences

Department of Pharmaceutical Sciences

Aimee L. Edinger is currently serving as a Developmental And Cell Biology Professor and Chancellor’s Fellow Developmental & Cell Biology at University of California, Irvine.

Honors

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Experiences

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Education

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Aimee L. Edinger

University of California, Irvine

Professor and Chancellor’s Fellow Developmental & Cell Biology

You can click a keyword to filter the displayed items

pharmacology immunology cell biology oncology medicine membrane biology virology hiv tumor biology cell signaling cell death cancer biology biological chemistry autophagy medicinal research mammalian biology general virology gene expression virus research molecular cell biology medicinal chemistry apoptosis viral genetics cancer cells molecular cancer molecular virology virus-host interactions clinical chemistry biochemical sciences tumor targeting anti-cancer agents medical virology nutrient physiology protein transport drug targeting viral pathogenesis adaptive immune system nutrient transporter expression liver physiology cellular physiology clinical microbiology cellular biology biological function cell regulation cancer treatment cancer genetics protein function antibody engineering chemokine receptors cancer metabolism viral persistence cancer prevention cancer genomics cancer immunosurveillance viral replication hematological malignancies cancer growth receptor (biochemistry) renal function inhibitory activity biological inorganic chemistry membrane transport chemoprevention strategies orphan receptors differential effects nutrient transporters ischemic stroke clearance function age-related myelin degradation akt maintains mtor-dependent nutrient uptake herpesvirus-encoded receptors simian immunodeficiency viruses mitochondrial physiology monocyte-derived dendritic cells nutrient scavenging

Notable Scholarly Works

Notable Federal Grants

Collaborators

Endolysosomal Trafficking Regulator Sh-Bc-893 Inhibits Coronavirus Entry in Vitro and in Vivo. Scientific Reports (2026)

virus researchantiviral researchsars-cov-2pathogenesisvirus-host interactionsgeneral virologyviral pathogenesismolecular virologymolecular cell biologyvirologyregulator sh-bc-893 inhibitsinfectious diseasescell biology

Mevalonate Biosynthesis is a Metabolic Vulnerability of Gemcitabine-Resistant Pancreatic Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2025)

biosynthesismetabolic remodelingcancer biologycancer researchmolecular cancerpancreatic cancermolecular metabolismmevalonate biosynthesiscancer cellsmetabolic pathwayscell metabolismtumor biologybiochemistrycell biology

Rab7A is Required to Degrade Select Blood-Brain Barrier Junctional Proteins After Ischemic Stroke. Acta Neuropathologica Communications (2025)

neurologycerebral vascular regulationcell deathischemic syndromeischemic strokethrombosisvascular biologymolecular neurosciencecerebral blood flowstrokeautophagyneuroscienceneurodegenerative diseasescell biology

Sphingosine Simultaneously Inhibits Nuclear Import and Activates Pp2A by Binding Importins and Ppp2r1a. The EMBO Journal (2025)

enzyme inhibitionmechanisms of actionactivates pp2acell signalingmolecular and cellular biologyprotein phosphorylationchemical biologymolecular cell biologymolecular biologybiological chemistrymolecular pathwayssignal transductionnuclear importcellular biochemistrybiochemistrycell biology

Abstract B071: A Genetic Approach to Selectively Inhibit Macropinocytosis While Sparing Autophagy. Cancer Research (2024)

Rebecca M LimBrandon ChuAimee Lara Edinger

cancer geneticscancer researchgeneticsoncologycancer biologyautophagy

Abstract C045: Targeting Metabolic Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Research (2024)

Taryn MorningstarCecily AnarakiLorenzo ScipioniGiulia TedeschiMichelle DigmanAimee EdingerClaus JorgensenMelissa FishelChristopher J Halbrook

cancer researchmetabolic heterogeneitypancreatic ductal adenocarcinoma

A High Dose Krp203 Induces Cytoplasmic Vacuoles Associated With Altered Phosphoinositide Segregation and Endosome Expansion. Biochemical and Biophysical Research Communications (2024)

Satoshi KofujiKara WolfeKazutaka SumitaShun KageyamaHirofumi YoshinoYoshihisa HirotaAki Ogawa-IioHirotaka KanohMika SasakiKaori KofujiMindy I. DavisRajan PraganiMin ShenMatthew B. BoxerFubito NakatsuKiyomi NigorikawaTakehiko SasakiKoh TakeuchiToshiya SendaSeong M. KimAimee L. EdingerAnton SimeonovAtsuo T. Sasaki

biophysicspharmacologyenzyme inhibitionbiochemical sciencesendosome expansionenzyme specificitymammalian biologyenzymesprotein expressioncancer biologyprotein sciencemembrane biologybiochemistry

Carmil1-Aa Selectively Inhibits Macropinocytosis While Sparing Autophagy. Molecular Biology of the Cell (2024)

Rebecca M. LimAlexa LuBrennan M. ChuangCecily AnarakiBrandon ChuChristopher J. HalbrookAimee L. Edinger

pathogenesiscell signalingcell researchinhibitory activitycell autophagyautophagycell biologystem cell researchmolecular cell biologycellular biologymolecular and cellular biologyinhibitory processautoantibody productiontumor biologyinhibits macropinocytosissystems biologymolecular biologycancer cellsmolecular medicine

Circulating Biomarkers of Kidney Angiomyolipoma and Cysts in Tuberous Sclerosis Complex Patients. iScience (2024)

Varvara I RubtsovaYujin ChunJoohwan KimCuauhtemoc B RamirezSunhee JungWonsuk ChoiMiranda E KellyMiranda L LopezElizabeth CassidyGabrielle RushingDean J AguiarWei Ling LauRebecca S AhdootMoyra SmithAimee L EdingerSang-Guk LeeCholsoon JangGina Lee

neurologybiomarkersproteomicskidney angiomyolipomahematologynephrologyurologyprognostic biomarkersrespiratory medicinemedicinal researchtuberous sclerosishealth sciences

Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy. Journal of the American Society of Nephrology (2023)

Kristin VöingUlf MichgehlNils David MertensCara PicciottoMee-Ling MaywaldJonas GoretzkoSofie WaimannKevin GilhausManuel RoggChristoph SchellJürgen KlingaufYaroslav TsytsyuraUwe HansenVeerle van MarckAimee L. EdingerBeate VollenbrökerUrsula RescherDaniela Anne BraunBritta GeorgeThomas WeideHermann Pavenstädt

endocytic pathwayneurologycell deathpathogenesisrenal functionnephrologygeneral virologysevere podocytopathychronic kidney diseasevirologypathway analysisrenal pathophysiologypathologyautophagygenome instabilitycell biology

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Aimee L. Edinger

Professor and Chancellor’s Fellow Developmental & Cell Biology

University of California, Irvine

Affiliations

School of Biological Sciences

Department of Developmental and Cell Biology

School of Pharmacy and Pharmaceutical Sciences

Department of Pharmaceutical Sciences

Aimee L. Edinger is currently serving as a Developmental And Cell Biology Professor and Chancellor’s Fellow Developmental & Cell Biology at University of California, Irvine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Aimee L. Edinger

University of California, Irvine

Professor and Chancellor’s Fellow Developmental & Cell Biology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Endolysosomal Trafficking Regulator Sh-Bc-893 Inhibits Coronavirus Entry in Vitro and in Vivo. Scientific Reports (2026)

Mevalonate Biosynthesis is a Metabolic Vulnerability of Gemcitabine-Resistant Pancreatic Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Rab7A is Required to Degrade Select Blood-Brain Barrier Junctional Proteins After Ischemic Stroke. Acta Neuropathologica Communications (2025)

Sphingosine Simultaneously Inhibits Nuclear Import and Activates Pp2A by Binding Importins and Ppp2r1a. The EMBO Journal (2025)

Abstract B071: A Genetic Approach to Selectively Inhibit Macropinocytosis While Sparing Autophagy. Cancer Research (2024)

Rebecca M LimBrandon ChuAimee Lara Edinger

cancer geneticscancer researchgeneticsoncologycancer biologyautophagy

Abstract C045: Targeting Metabolic Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Research (2024)

Taryn MorningstarCecily AnarakiLorenzo ScipioniGiulia TedeschiMichelle DigmanAimee EdingerClaus JorgensenMelissa FishelChristopher J Halbrook

cancer researchmetabolic heterogeneitypancreatic ductal adenocarcinoma

A High Dose Krp203 Induces Cytoplasmic Vacuoles Associated With Altered Phosphoinositide Segregation and Endosome Expansion. Biochemical and Biophysical Research Communications (2024)

biophysicspharmacologyenzyme inhibitionbiochemical sciencesendosome expansionenzyme specificitymammalian biologyenzymesprotein expressioncancer biologyprotein sciencemembrane biologybiochemistry

Carmil1-Aa Selectively Inhibits Macropinocytosis While Sparing Autophagy. Molecular Biology of the Cell (2024)

Rebecca M. LimAlexa LuBrennan M. ChuangCecily AnarakiBrandon ChuChristopher J. HalbrookAimee L. Edinger

Circulating Biomarkers of Kidney Angiomyolipoma and Cysts in Tuberous Sclerosis Complex Patients. iScience (2024)

neurologybiomarkersproteomicskidney angiomyolipomahematologynephrologyurologyprognostic biomarkersrespiratory medicinemedicinal researchtuberous sclerosishealth sciences

Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy. Journal of the American Society of Nephrology (2023)

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